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Background

Other Alzforum’s Papers database contains a list of citations focused on Alzheimer’s disease and related neurodegenerative disorders. The database is updated weekly, with additions announced in Alzforum’s “Papers of the Week.” Alzforum started the database in 1

FAQ

Other Q: Why is this paper, which was just published, not in the database? A: There is usually a delay between when a paper is published online and when it is entered in PubMed. See also our selection criteria in the Methods page. Q: Can I get the full text of

Methods

Other The PubMed database is searched nightly, using a broad range of terms as keyword searches. Alzforum curators screen the abstracts and select papers based on their perceived interest to Alzheimer’s disease researchers. All papers directly related to Alzhei

Damaging Variants in SORL1: Key Findings on AD Risk

Other Multiple studies have associated rare variants in SORL1 with an increased risk of Alzheimer’s disease. To achieve enough statistical power to detect an association—individual variants being quite rare, with many found in only a single carrier thus far—the

ApoE

Other Apolipoprotein E (ApoE) is a secreted lipoprotein involved in cholesterol metabolism, and the ε4 allele of ApoE is the strongest known genetic risk factor for late-onset Alzheimer’s disease. Multiple mechanisms have been suggested to underlie ApoE’s effec

P2Y12R

Other P2Y purinoceptor 12 (P2Y12R) is a G-protein coupled receptor that mediates the movement of microglia toward purinergic nucleotides—ADP and ATP—that may be released by damaged cells (Haynes et al., 2006). P2Y12R is frequently said to be a marker of homeost

TMEM119

Other Transmembrane protein 119 (TMEM119) is a cell-surface protein which, in the brain, is found exclusively in microglia (Butovsky et al., 2014; Bennett et al., 2016; Satoh et al., 2016). Its function in microglia is not yet known, but in the periphery, this

CX3CR1

Other CX3C motif chemokine receptor 1 (CX3CR1) is a G protein-coupled receptor found on microglia. Its ligand, fractalkine (also known as CX3CL1), is produced by neurons. CX3CR1 is often referred to as a marker of homeostatic microglia, as its expression is dow

TYROBP/DAP12

Other TYRO protein tyrosine kinase-binding protein (TYROBP), also known as DNAX-activation protein 12 (DAP12) and killer cell activating receptor-associated protein (KARAP), is the adaptor protein that mediates TREM2 signaling in microglial cells. Mutations in

CD33

Other CD33, a transmembrane receptor of the innate immune system, is expressed on the surface of microglial cells. Genome-wide association studies (GWAS) have linked variants in CD33 to Alzheimer’s disease risk, and both disease-promoting and protective alleles

CLEC7A

Other CLEC7A (C-type lectin domain family 7 member A, also known as dectin-1) is a pattern recognition receptor found on cells of the innate immune system, where it binds components of the cell wall of fungi and elicits an anti-fungal response. Injured mammalia

ABI3

Other ABI3, ABI gene family member 3, is a member of a protein family that regulates the actin cytoskeleton (Sekino et al., 2015). A rare variant in ABI3, p.S209F (rs616338), is associated with an increased risk of Alzheimer’s disease (Sims et al., 2017; Conway

AlzAntibodies

Other The AlzAntibodies database replaces the Antibodies database. This new database aims to provide detailed descriptions of selected antibodies rather than a catalog of a large number of antibodies. We welcome community feedback on this new effort: Which anti

Helmholtz Antibody Collection

Other The following are selected lists of antibodies against microglial proteins that are available through the Monoclonal Antibody Core Facility at Helmholtz Munich.  ABI3 | ApoE | CD33 | CLEC7A | CX3CR1 |  P2Y12R  | TMEM119 | TYROBP/DAP12 Tested Applications:

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