Scientists discussed anti-Aβ therapeutic antibodies, confirming their ability to remove brain amyloid and working to boost their brain exposure. They continued their postmortem of BACE inhibitors in hopes of reviving these drugs at lower doses. Efforts at targeting tau are shifting toward tau’s microtubule-binding section, and α-synuclein trials are grappling with rates of disease progression. Emerging neurophysiology-based treatment approached presented promising early stage data, and clinicians shared experiences dealing with a year of COVID disrupting their trials and worsening their patients across neurologic care. Plus: cool news on astrocytes, tau blood tests, better mouse models and more. Check it all out here.