This database aims to provide detailed descriptions of selected antibodies related to the study of Alzheimer’s disease.
This interactive database captures two decades of research on fluid biomarkers for Alzheimer's disease. Curated measurements and related data from peer-reviewed articles are presented, as well as meta-analyses for selected biomarkers. This resource, developed in collaboration with Henrik Zetterberg and colleagues at the University of Gothenburg, will be expanded over time as new data become available.
AlzGene is a collection of published Alzheimer's disease genetic association studies with random-effects meta-analyses for various polymorphisms. This database was last updated in 2011, and no further changes to the database are anticipated.
AlzPedia serves as a quick reference guide that provides brief summaries of various genes and proteins implicated in the pathophysiology of Alzheimer’s disease and other neurodegenerative disorders.
AlzRisk is a collection of findings from published epidemiologic reports that evaluate environmental and other non-genetic risk factors for Alzheimer's disease. The database includes study summaries and meta-analyses, when applicable.
This database lists brain banks around the world that collect central nervous system tissue from various neurodegenerative diseases and normal controls, and share samples and information with qualified researchers worldwide. Many brain banks operate as part of larger consortia that maintain virtual inventories of their combined holdings and offer a centralized portal to match tissue requests with local supplies.
The Healthy Exomes database is a repository of genetic variants predicted to be benign with respect to age-associated neurodegenerative brain disease. It contains whole-exome sequencing results from nearly 500 individuals over the age of 60 who did not have a neurodegenerative disease diagnosis or disease-associated neuropathology at the time of their death. This database provides a unique reference cohort of aged individuals without evidence of neurodegenerative disease. HEX is developed in collaboration with Jose Bras and Rita Guerreiro, University College of London.
This database is a repository of variants in genes implicated in Alzheimer’s disease (AD). Currently, it includes the three genes associated with autosomal-dominant AD (APP, PSEN1, PSEN2) plus three genes associated with AD through association studies or pathology (APOE, MAPT, and TREM2). The goal is to provide a comprehensive list of variants in these genes that have been reported in the literature, and to briefly describe associated clinical and neuropathological features as well as functional effects..
This database contains information about over one hundred mouse models relevant to the study of Alzheimer’s disease, Amyotrophic Lateral Sclerosis, and related neurodegenerative diseases. This database is a work in progress and will be expanded over time.
This is a collection of detailed protocols, submitted from individual laboratories, which outline the reagents and experimental approaches used in different aspects of Alzheimer's disease research.
The Therapeutics Database provides information about drugs and other therapeutic approaches currently or previously tested in clinical trials for use in Alzheimer's disease and other neurodegenerative disorders.