This interactive database captures two decades of research on fluid biomarkers for Alzheimer's disease. Curated measurements and related data from peer-reviewed articles are presented, as well as meta-analyses for selected biomarkers. This resource, developed in collaboration with Henrik Zetterberg and colleagues at the University of Gothenburg, will be expanded over time as new data become available.
AlzGene is a collection of published Alzheimer's disease genetic association studies with random-effects meta-analyses for various polymorphisms.
AlzPedia serves as a quick reference guide that provides brief summaries of various genes and proteins implicated in the pathophysiology of Alzheimer’s disease and other neurodegenerative disorders.
AlzRisk is a collection of findings from published epidemiologic reports that evaluate environmental and other non-genetic risk factors for Alzheimer's disease. The database includes study summaries and meta-analyses, when applicable.
This database contains information about more than 30,000 antibodies related to the study of Alzheimer’s disease and other areas of neuroscience. Antibodies from both commercial and laboratory sources are included.
This database lists brain banks around the world that collect central nervous system tissue from various neurodegenerative diseases and normal controls, and share samples and information with qualified researchers worldwide. Many brain banks operate as part of larger consortia that maintain virtual inventories of their combined holdings and offer a centralized portal to match tissue requests with local supplies.
The Healthy Exomes database is a repository of genetic variants predicted to be benign with respect to age-associated neurodegenerative brain disease. It contains whole-exome sequencing results from nearly 500 individuals over the age of 60 who did not have a neurodegenerative disease diagnosis or disease-associated neuropathology at the time of their death. This database provides a unique reference cohort of aged individuals without evidence of neurodegenerative disease. HEX is developed in collaboration with Jose Bras and Rita Guerreiro, University College of London.
This database contains information about mutations in genes linked to autosomal-dominant Alzheimer’s disease as well as mutations in MAPT (tau). The goal is to provide a comprehensive list of rare variants in these genes, causative as well as benign, and to briefly describe the associated clinical and neuropathological features and reported functional effects.
This is a collection of detailed protocols, submitted from individual laboratories, which outline the reagents and experimental approaches used in different aspects of Alzheimer's disease research.
The Therapeutics Database provides information about drugs and other therapeutic approaches currently or previously tested in clinical trials for use in Alzheimer's disease and other neurodegenerative disorders.