SEARCH RESULTS

6106 RESULTS

Sort By:

Paper Alert: APOE4 Packs on Lipid Droplets in Microglia

RESEARCH NEWS 2024-03-13 Research News Last year, scientists led by Tony Wyss-Coray, Stanford University, reported that Aβ induced formation of lipid droplets within human microglia, and attributed this to an uptick in a triglyceride synthesis enzyme. APOE4 aggravated lipid dropl

HIV Drug Safe in Alzheimer’s Pilot Trial, Nudged Biomarkers

RESEARCH NEWS 2024-03-12 Research News Almost half of a person's DNA consists of retrotransposons, remnants of ancient viral infections that have jumped around the human genome. Retrotransposons are typically kept under wraps by epigenetics, but tau can unleash those restrai

Nearly Two Years After FDA Approval, Relyvrio Bombs Phase 3 for ALS

RESEARCH NEWS 2024-03-08 Research News Enticing a reluctant FDA Advisory Committee to greenlight its drug based solely on Phase 2, Amylyx Pharmaceuticals promised, sort of, that if its ongoing Phase 3 trial returned negative results, it would voluntarily withdraw the drug. Those

Neuroprotective Extracellular Matrix Seen in C9ORF72 ALS/FTD Models

RESEARCH NEWS 2024-03-07 Research News Amyotrophic lateral sclerosis and frontotemporal dementia are heterogeneous diseases that are difficult to fully model in mice. One of the more common forms is caused by hexanucleotide repeat expansion in the gene C9ORF72, which prompts both

Do Sleep Rhythms Create Ion Waves That Rinse the Brain?

RESEARCH NEWS 2024-03-05 Research News During sleep, the brain cleans itself, turning up the flow of cerebrospinal fluid through the gray matter parenchyma to wash away waste. What powers this flow? In the February 28 Nature online, researchers led by Jonathan Kipnis at Washingto

More on Moribund Mitochondrial Respiration Prior to Plaques

RESEARCH NEWS 2024-03-05 Research News The brain's metabolism starts to wane decades before Alzheimer's symptoms. Why the energy deficit? Scientists led by Andrés Norambuena and George Bloom at the University of Virginia, Charlottesville, blame failure of a specific typ

Tau Fragments in Plasma Track with Tangles, Cognitive Decline

RESEARCH NEWS 2024-03-01 Research News While numerous fluid markers flag brain Aβ pathology in Alzheimer’s disease, markers of neurofibrillary tangles are few and far between. Now, scientists led by Oskar Hansson at Lund University in Sweden and Juan Lantero-Rodriguez of the Univ

Different Cellular Mechanisms in Familial and Sporadic Alzheimer’s?

RESEARCH NEWS 2024-02-29 Research News How alike are familial and sporadic Alzheimer’s? It depends. Broadly speaking, in terms of their presymptomatic biomarker changes, the two resemble each other closely (see Feb 2024 news). In terms of what goes on inside affected cells, thing

No Loitering: Pathogenic Liaisons Trap TDP-43 in the Cytoplasm

RESEARCH NEWS 2024-02-29 Research News TDP-43 leads a varied life, interacting with a host of different RNAs and proteins as it shuttles from the nucleus to the cytoplasm and back. This offers this RNA-binding protein plenty of opportunities to take up with the wrong crowd. Case

While a Fly Sleeps, Its Glia Burn Neuronal Lipids to Refresh the Brain

RESEARCH NEWS 2024-02-27 Research News How does a good night’s sleep re-energize the brain? At least in fruit flies, by burning damaged lipids. So claim scientists led by Amita Sehgal at the University of Pennsylvania in Philadelphia. In the February 15 Nature Neuroscience, they

‛iNET’ Cultures Expose NPTX2 as TDP-43 Henchman

RESEARCH NEWS 2024-02-23 Research News The pathological accumulation of TDP-43 that underlies many cases of FTD, ALS, and LATE-NC has been notoriously difficult to recapitulate in mice or cultured human cells. In a paper published February 14 in Nature, scientists led by Magdalin

In Diabetes, Tight Blood Sugar Control Staves Off Dementia

RESEARCH NEWS 2024-02-21 Research News Type 2 diabetes (T2D) raises a person’s risk of developing dementia by about 50 percent. Does tightly controlling blood sugar decrease that risk? Yes, according to researchers led by Eng-Kiong Yeoh and Kailu Wang at the Chinese University of

Current Filters

  • TYPE: News x

Remove all filters

Filter By

DATE RANGE
  • All
  • Past 7 Days
  • Past 30 Days
  • Past 90 Days
  • Past 12 Months
  • Specific Dates
    1. From
      To

TYPE
TYPE OF NEWS
DISEASE
TOPIC
BIOMOLECULE