Males are inflammatory, females are neuroprotective: Profiling of microglia from adult mice suggests sex-specific phenotypes, likely set at birth.
Roche and Prothena publish Phase 1b results for their antibody PRX002/RG7935.
Big data analyses correlate viral load with clinical, molecular, and pathological features of AD. Time to consider the pathogen hypothesis anew?
A large epidemiological study better defines the risk from hypertension. This may sharpen recommendations for prevention.
Two papers report that the ApoE4 allele triggers both hallmarks of AD in iPSC-derived cultures, in contrast to its minimal effects in mouse neurons.
Overexpression of synaptojanin 1 leads to hippocampal place cell dysfunction in mice. Could it contribute to memory problems in AD?
In an unselected cohort, amyloid-PET scans changed clinical diagnoses and treatment plans for a quarter of participants.
Study suggests a diabetes drug under investigation for both Parkinson’s and Alzheimer’s diseases acts by quieting microglia and shutting down the pathological activation of astrocytes.
After veru- and atabecestat, now a third β-secretase inhibitor, by Eli Lilly and AstraZeneca, is being pulled from ongoing Phase 3 trials of symptomatic Alzheimer’s disease.
Though the dipeptides interacted with many proteins in cell culture, they associated specifically with ribosomes in the human brain.
In mice, antisense oligonucleotides that splice out more than half of the Aβ peptide drive down its levels in the brain.
By prying open chromatin, neurofibrillary tau may expose dormant transposable elements for transcription.
Recent studies have identified rare loss-of-function variants that cause Alzheimer’s with nearly 100 percent penetrance. Now there are 17 more.
In 18-month data from a small trial, elenbecestat appeared well-tolerated, with no signs of liver toxicity. PET imaging indicated a drop in brain amyloid, while clinical endpoints trended toward a slowing of cognitive decline.
Outcomes emphasize big data, new technology, environmental and genetic risk in hopes of enabling precision medicine.
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