A panel of experts concludes the evidence for this scary prospect is weak, but recommends neurosurgeons use separate neurosurgical instruments for young and old patients. The experts called for further studies.
Learning tests may prove more informative in clinical trials of early AD. A new one claims it can spot a difference in six days.
Restoring proper gene editing assuaged mitochondrial defects in patient-derived neurons and organoids. Splicing errors may underlie other PD cases as well.
AMX0035, a mix of sodium phenylbutyrate and taurursodiol, slowed functional decline over six months by about as much as the approved ALS drug edaravone.
A C9ORF72 polydipeptide repeat induces aggregation by direct interaction with TDP-43, while progranulin mutations that trigger microglial toxicity cause TDP-43 to accumulate via complement.
In a career spanning four decades, Davies spearheaded the cholinergic hypothesis, unlocked secrets of tau, and readily shared antibodies in the field.
The designer chimera stabilizes synapses in various mouse models of neurodegenerative disease.
The antiviral protein enhances γ-secretase processing of APP. More of it is present in Alzheimer’s disease.
Alzforum encourages users to visit the Virtual Exhibit Hall, where companies showcase their newest initiatives, products, and services. We welcome F. Hoffmann-La Roche, joining our other exhibitors — Biogen, BioLegend, Abcam, BrainXell, and the Jackson Laboratory.
The evidence for neurosurgical transfer of amyloid seeds is sparse and circumstantial at best, according to a new white paper by 37 experts in the field. However, they believe the issue deserves more study. In the meantime, the authors recommend neurosurgeons use separate instruments to operate on young and old patients.
Memory problems in the preclinical stage of Alzheimer’s disease are notoriously subtle and difficult to pick up. Problems with learning something new are much more pronounced, according to a new study—at least if that something new is Chinese. Scientists evaluating a new six-day cognitive test report that otherwise asymptomatic people learned the meaning of 50 Chinese characters much more slowly if they had amyloid in their brain. The test might become a sensitive tool in clinical trials of early AD.
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