Multi-Organ MRI Unveils Myriad Connections Between Heart and Brain
Dozens of structural features of the heart correlated with measures of regional volume, integrity of white-matter tracts, and functional connectivity within the brain.
NEWS
CMS Sticks to Its Guns on Amyloid Immunotherapy Coverage
The agency reiterated its earlier decision that traditionally approved amyloid antibodies will be covered if physicians enter data into a patient registry.
In Amyloid Cascade, Do Reactive Astrocytes Bridge Plaques and Tangles?
Among cognitively healthy people, amyloid load tracked with blood p-tau181 and tangles only in those with high blood GFAP.
When Autophagy Stops, Microglia Sour into Senescence
Backed up, the cells never transitioned into a disease-associated state, shirking their plaque compaction and synapse protection duties.
Nature Aging Issue Focuses on Dementia Research
Three reviews, two perspectives, and four comments discuss recent advances and opportunities for dementia research.
Abnormal Tau Slips into Synapses Long Before Tangles Form
More evidence that presynaptic tau may spread from neuron to neuron.
Does “Good” Cholesterol Increase Your Risk of Alzheimer’s?
Mendelian randomization identified HDL cholesterol and systolic blood pressure as modifiable risk factors.
Amyloid Jungle: Plaque Fibrils Mesh With All Manner of Vesicles, Membranes
Arranged in bundles and lattices within a plaque, Aβ42 fibrils were intermixed with extracellular vesicles of different shapes and sizes. Their origin remains unknown.
SPOTLIGHT
In Amyloid Cascade, Do Reactive Astrocytes Bridge Plaques and Tangles?
Not everyone with amyloid plaques quickly progresses to symptomatic Alzheimer’s. New research blames astrocytes for driving disease progression. In three observational cohorts, plaque load correlated with p-tau and tangles only in people whose plasma GFAP was high. Does GFAP hold potential as a prognostic biomarker?
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