Big data analyses correlate viral load with clinical, molecular, and pathological features of AD. Time to consider the pathogen hypothesis anew?
A large epidemiological study better defines the risk from hypertension. This may sharpen recommendations for prevention.
Two papers report that the ApoE4 allele triggers both hallmarks of AD in iPSC-derived cultures, in contrast to its minimal effects in mouse neurons.
Overexpression of synaptojanin 1 leads to hippocampal place cell dysfunction in mice. Could it contribute to memory problems in AD?
In an unselected cohort, amyloid-PET scans changed clinical diagnoses and treatment plans for a quarter of participants.
Study suggests a diabetes drug under investigation for both Parkinson’s and Alzheimer’s diseases acts by quieting microglia and shutting down the pathological activation of astrocytes.
After veru- and atabecestat, now a third β-secretase inhibitor, by Eli Lilly and AstraZeneca, is being pulled from ongoing Phase 3 trials of symptomatic Alzheimer’s disease.
Though the dipeptides interacted with many proteins in cell culture, they associated specifically with ribosomes in the human brain.
Virtual Exhibit Hall
Alzforum has just launched a Virtual Exhibit Hall, a place for companies to showcase their initatives, products, and services. We welcome our inaugrual exhibitors - Biogen, BioLegend, and The Jackson Laboratory and encourage our readers to explore their virtual booths here.
A large-scale analysis of data from several different brain banks reports that herpesviruses are more abundant in the brains of Alzheimer's patients, and suggests that they perturb regulatory genetic networks involved in the preclinical pathogenesis of the disease. The study brings a new group of scientists and new methodologies to bear on the controversial hypothesis that viruses are involved in some cases of Alzheimer's disease. Is it time to consider clinical trials of antiviral drugs?
Recent work suggests that normally neuroprotective astrocytes can be transformed into dangerous killers, thanks to inflammatory cytokines produced by activated microglia. A new study suggests these astrocytes are responsible for neuronal cell death in two mouse models of Parkinson’s disease, and that they can be quieted by a class of diabetes drugs now in clinical trials for PD and AD.
Will RNA molecules that bump up or tamp down gene expression live up to their potential? Results from RNA-targeting therapies presented at the 70th annual meeting of the American Academy of Neurology in Los Angeles suggest children with spinocerebellar ataxia continue to improve years after starting approved treatments. However, prices are high and so far, health gains are modest. Will similar approaches for Huntington’s disease, ALS, familial amyloid polyneuropathy, and tauopathies fare better? Check out our two-part story.
- Margot Mayer-Proschel on Aberrant Networks in Alzheimer’s Tied to Herpes Viruses
- John Hardy on Aberrant Networks in Alzheimer’s Tied to Herpes Viruses
- Charlotte Warren-Gash on Aberrant Networks in Alzheimer’s Tied to Herpes Viruses
- Hugo Lövheim on Aberrant Networks in Alzheimer’s Tied to Herpes Viruses
- Richard Lathe and Jurgen Haas on Aberrant Networks in Alzheimer’s Tied to Herpes Viruses
- Lars M. Ittner on In Human Neurons, ApoE4 Promotes Aβ Production and Tau Phosphorylation
- Rebecca Gottesman on Blood Pressure Affects Dementia Risk Only in People Under 60
- Timo Strandberg on Herpes Viruses and Senile Dementia: First Population Evidence for a Causal Link.
- Steven Harris on Herpes Viruses and Senile Dementia: First Population Evidence for a Causal Link.
- Edwin J. Weeber on In Human Neurons, ApoE4 Promotes Aβ Production and Tau Phosphorylation
- David Holtzman on In Human Neurons, ApoE4 Promotes Aβ Production and Tau Phosphorylation
- Kristel Sleegers on Gaining Notoriety, SORL1 Claims Spot Among Top Alzheimer’s Genes
- Henryk Barthel on For One in Four Memory Clinic Patients, Amyloid-PET Changes the Diagnosis
- Inna Slutsky on Synaptojanin 1 Gene Affects Age of Onset in Familial AD, Memory in Mice
- Dongming Cai on Synaptojanin 1 Gene Affects Age of Onset in Familial AD, Memory in Mice
- Eric Siemers on Scratch Lanabecestat: This BACE Inhibitor Doesn’t Work in Symptomatic AD, Either
- Marzia Maria Lecchi on Does Taming Killer Astrocytes Spare Neurons in Parkinson’s Disease?
- Pierre Tariot on Scratch Lanabecestat: This BACE Inhibitor Doesn’t Work in Symptomatic AD, Either
- Michael Rae on U.S. Study Says Lithium in Tap Water Does Not Fend Off Dementia
- Antonina Dolei on Tau Aggregates Awaken Genetic Relics in the Brain
- Eric M. Reiman on Scratch Lanabecestat: This BACE Inhibitor Doesn’t Work in Symptomatic AD, Either