Two epigenetic proteins accelerated age-related behavioral decline in worms and in mice, at least partly by dampening mitochondrial function. Orthologs in the human brain ramped up with aging and with AD progression.
Amyloid and tau PET are helping scientists pinpoint the underlying cause of specific AD symptoms. Perhaps imaging of certain brain regions will help predict an individual’s progression.
At the HAI 2020 conference, the tracers PI-2620 and APN-1607 appeared to bind frontotemporal dementia tau. MK-6240 looked highly sensitive. And JNJ-067 and SNFT-1 are two new kids in town.
Vision improved in some retinitis pigmentosa patients in a Phase 1 trial.
Two studies reveal new aspects of the neurovascular physiology that regulate the flow of oxygenated blood into the brain’s arterioles and capillaries in response to neuronal stimulation.
The protease suppresses Aβ in Down’s syndrome organoids.
Post-translational modifications differ from those in AD tau fibrils, and may dictate tau strains.
The creation of long-term memories requires a continual supply of myelin provided by newly formed oligodendrocytes. Alas, the generation of fresh oligodendrocytes diminishes with age, along with memory.
Alzforum encourages users to visit the Virtual Exhibit Hall, where companies showcase their newest initiatives, products, and services. We welcome F. Hoffmann-La Roche, joining our other exhibitors — Biogen, BioLegend, Dash Genomics, Inc., Abcam, BrainXell, and the Jackson Laboratory.
Across the rapidly expanding field of tau PET, eight tracers are currently in research development on different continents. Scientists at HAI, held earlier this year in Miami, Florida, presented new data on how they are being studied. Their on-target and off-target binding, their sensitivity, and which of several forms of pathological tau aggregate they recognize are all under scrutiny. Some groups perform direct side-by-side comparisons of multiple tracers, though those remain few and far between. Which tracer is best? The answer may depend on your application. One thing is for sure: researchers’ toolbox is growing.
How does fresh arterial blood make its way through the vast web of tiny vessels in the brain to reach the hungriest neurons? Using live imaging in mice, two studies reveal new elements of neurovascular physiology that play a role. For one, arteriolar endothelial cells were covered with inlets called caveolae, which somehow dictated the dilation and contraction of the vessels. The other identified specialized sphincters that controlled the flow of blood from arterioles into downstream capillary beds.
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