Flash! Beep! Gamma Waves Stimulate Microglia, Memory
Exposing AD mice to multisensory gamma therapy induced 40-Hz waves in their brains, plus effects on amyloid, tau, microglia, blood vessels, and cognitive function.
NEWS
In New Study, Diet During Midlife Not Linked to Dementia
Among British civil servants, the quality of their diet did not correlate with their risk of developing dementia cognitive decline over 25 years.
Deep Blue for Aβ Blood Test?
IBM researchers in Australia identify a combination of four proteins in plasma that predicts amyloid positivity in cerebrospinal fluid, and correlates with progression to AD.
CRISPR Suppresses BACE1 and Plaques in Mice
Deleting BACE1 with CRISPR nanocomplexes tempered Aβ pathology and boosted memory.
More Evidence for Distinct TDP-43 Droplets
Liquid beads of TDP-43 form independently of stress granules and sequester proteins needed for nucleocytoplasmic transport.
Dementia Researchers Commend FDA Crackdown on Supplement Hype
When the agency sent warning letters to 17 companies that falsely advertised cures and preventions for AD, most took down exaggerated claims. But can regulations stay ahead of the market?
Too Little, Too Late? Blood Pressure and Cholesterol Meds Don’t Slow Cognitive Decline in 70s
In people at intermediate risk for cardiovascular disease, the meds had no effect on cognitive decline over six years.
Does High Iron Push a Person With Pathology Into Dementia?
How the element relates to neurodegeneration remains unclear.
Virtual Exhibit Hall
Alzforum encourages users to visit the Virtual Exhibit Hall, where companies showcase their newest initiatives, products, and services. We welcome Dash Genomics, Inc. and Abcam, which join our other exhibitors — Biogen, BioLegend, BrainXell, NanoString Technologies, and the Jackson Laboratory.
SPOTLIGHT
Dementia Researchers Commend FDA Crackdown on Supplement Hype
On the internet, a plethora of companies claim their herbal and natural products prevent, fight, or even cure dementia—but there’s no solid science behind these promises. The U.S. Food and Drug Administration is stepping up its policing of these companies. It issued warnings to more than a dozen. Alzheimer’s researchers welcome the move, but will it be enough?
Pulsing Tones, Flashing Lights Lessen Alzheimer’s Symptoms in Mice
Using light and sound to synchronize neuronal firing, researchers induce gamma waves in the brains of AD mouse models. Scientists claim that a week of auditory flicker treatment—with tones that beep at 40-Hz—impels microglia to eat plaques in the auditory cortex and hippocampus and activates astrocytes. Blood vessels also appear to dilate; memory improves. If paired light flashes stimulate the eyes at the same time, the effects reach into the medial prefrontal cortex and cause microglia to cluster around plaques. Translation to people is in the works.
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