New Tool: Microglia-Specific Reporter Mice, With Choice of Colors
Two groups create mice for imaging and manipulation of microglia, leaving related cells untouched. The trick? Piggybacking on Tmem119 expression.
NEWS
Meet medRχiv: A New Preprint Server for Health Research
Today, the creators of bioRχiv launch a repository for preliminary medical research, including clinical trial data.
Drawing Closer: Alzheimer’s Blood Test for Primary Care
Fully automated immunoassay could offer cost-effective screening for AD.
NfL: Useful in Differential Diagnosis?
A meta-analysis of 47 studies suggests CSF NfL is particularly elevated in a select few, suggesting it could help in differential diagnosis.
Aβ Acts Through Pericytes to Throttle Brain Blood Flow
In response to the peptide, these little cells squeeze capillaries, constricting them. This may contribute to neuronal dysfunction.
Wild Mice Inject Genetic Diversity into Models of Alzheimer’s Disease
New strains have amyloid, neurodegeneration, and neuroinflammation, all against a background of natural genetic variation.
Do Brain Waves During Sleep Reflect Aβ and Tau Pathologies?
In healthy, older adults specific EEG patterns correlated with plaque and tangle burdens.
TADPOLE Challenge: Winners Forecast AD Symptoms
Using different techniques, contestants vied for the best way to tell which ADNI participants would develop clinical, cognitive, or imaging signs of Alzheimer’s disease.
Virtual Exhibit Hall
Alzforum encourages users to visit the Virtual Exhibit Hall, where companies showcase their newest initiatives, products, and services. We welcome Dash Genomics, Inc. and Abcam, which join our other exhibitors — Biogen, BioLegend, BrainXell, NanoString Technologies, and the Jackson Laboratory.
SPOTLIGHT
Acting Locally and Globally, Aβ Sets Stage for Neurodegeneration
Though amyloid plaques are a hallmark of Alzheimer’s disease, their distribution has never correlated well with cognitive decline. Now, scientists think they know why. According to new research, plaques weaken distant, connected neurons, making them vulnerable to stress. Nearby plaques then disrupt those vulnerable neurons, causing learning and memory problems. The study suggests that global and local Aβ conspire to bring about dementia.
Dead Microglia Pave the Way for Myelin Regeneration
In mice, myelin repair seems efficient only when pro-inflammatory microglia perish and pro-regenerative ones take their place. The old cells die by necroptosis, a type of programmed cell death. Microglial necroptosis and regeneration occur at sites of myelin repair in multiple sclerosis models. It remains to be see whether a similar cellular switcheroo happens in people or in other diseases that cause demyelination, including Alzheimer’s.
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