When Autophagy Stops, Microglia Sour into Senescence
Backed up, the cells never transitioned into a disease-associated state, shirking their plaque compaction and synapse protection duties.
NEWS
Nature Aging Issue Focuses on Dementia Research
Three reviews, two perspectives, and four comments discuss recent advances and opportunities for dementia research.
Abnormal Tau Slips into Synapses Long Before Tangles Form
More evidence that presynaptic tau may spread from neuron to neuron.
Does “Good” Cholesterol Increase Your Risk of Alzheimer’s?
Mendelian randomization identified HDL cholesterol and systolic blood pressure as modifiable risk factors.
Amyloid Jungle: Plaque Fibrils Mesh With All Manner of Vesicles, Membranes
Arranged in bundles and lattices within a plaque, Aβ42 fibrils were intermixed with extracellular vesicles of different shapes and sizes. Their origin remains unknown.
Brain Within a Brain? Nested Organoids a New Way to Study Human Microglia
Transplanting a human cerebral organoid containing microglia into a mouse brain allows the cells to thrive in something close to their natural environment.
Hi-Res Spatial Proteomics Uncovers Aspects of Alzheimer’s Disease Pathology
Multiplex analyses spy a new microglial subtype that surrounds Aβ plaques, and a type of neuron resilient to neurofibrillary tangles.
Paper Alert: Those Fibrils Floating in Brain Fluid Are Toxic
They can be neutralized by lecanemab, an anti-amyloid antibody designed to mop up Aβ protofibrils.
SPOTLIGHT
Plaque Jungle
Using cryo-electron tomography, a new study offers a glimpse of the molecular ecosystem of an amyloid plaque. Organized in parallel bundles and lattices, Aβ fibrils mingled with a great many vesicles of different shapes and sizes. Which cells made the vesicles, or how they wound up within plaques, remains a mystery.
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