FDA Approves First RNAi Therapy
The drug, patisiran, targets messenger RNAs that cause transthyretin amyloidosis, a rare inherited neurodegenerative disease. Approval paves the way for other RNAi-based therapies.
NEWS
ApoE: Common Microglial Culprit in Aging, Alzheimer’s, and Tauopathy?
Translatome profiling suggests ApoE drives a microglial gene-expression signature found in aging, Aβ amyloidosis, and tauopathy.
Donepezil Not the Answer for Depressed MCI Patients
The acetylcholinesterase inhibitor failed to slow cognitive decline in people with both depression and mild cognitive impairment.
Focused Ultrasound Breaches Blood-Brain Barrier in People with Alzheimer’s
Data from the first human study hints the procedure could help deliver drugs to the brain, or even work as a therapy in its own right. A flurry of animal studies presented at AAIC support the idea.
No Mutation Required? Cell Stress Goads Aggregation of Wild-Type SOD1
In mice, aggregates of oxidized SOD1 accumulated with age, and endoplasmic reticulum stress made it worse. Does this explain SOD1 aggregates found in spinal cords of patients with sporadic ALS?
Alzheimer’s Disease-Related Proteins Needed for Neurogenesis
The hippocampus trickles out new neurons throughout life, a process that falters without BACE1 or in the presence of ApoE4.
Could Better Blood Pressure Management Preserve Cognition?
In SPRINT MIND trial, strict control of systolic pressure slashed MCI incidence by almost 20 percent.
PET Ligand Lights Up AAIC, May Detect Synapse Loss in AD
UCB-J hints at early synaptic loss in the hippocampus, but not the cortex. Researchers puzzle over the pattern.
Virtual Exhibit Hall
Alzforum has launched a Virtual Exhibit Hall, a place for companies to showcase their initatives, products, and services. We welcome our exhibitors - Biogen, BioLegend, Nanostring Technologies, Inc., and The Jackson Laboratory and encourage our readers to explore their virtual booths here.
SPOTLIGHT
Neuroinflammation Workshop in Southern Spain
Once considered a passive response, neuroinflammation has earned a reputation as a driver of neurodegeneration. Are you thinking of jumping into the field? Neuroinflammation School 2018: NeuroInflammation Meets NeuroDegeneration might be your ticket. To be held October 15 to 20 in Conil de la Frontera, near Cadiz, in Andalusia, Spain, this six-day workshop is organized by Michael Heneka from the University of Bonn, Germany, and covers the players of the immune system and their role in Alzheimer’s, ALS, multiple sclerosis, and other neurodegenerative and neuroinflammatory disorders. Faculty will lead discussions on latest research, help generate hypotheses for future studies, and coach students, postdocs, and young investigators on how to sharpen their research skills. Email michael.heneka@dzne.de or iracz@uni-bonn.de for more info and to apply for one of the limited number of spots.
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