Multi-Organ MRI Unveils Myriad Connections Between Heart and Brain
Dozens of structural features of the heart correlated with measures of regional volume, integrity of white-matter tracts, and functional connectivity within the brain.
Dozens of structural features of the heart correlated with measures of regional volume, integrity of white-matter tracts, and functional connectivity within the brain.
The agency reiterated its earlier decision that traditionally approved amyloid antibodies will be covered if physicians enter data into a patient registry.
Among cognitively healthy people, amyloid load tracked with blood p-tau181 and tangles only in those with high blood GFAP.
Backed up, the cells never transitioned into a disease-associated state, shirking their plaque compaction and synapse protection duties.
Three reviews, two perspectives, and four comments discuss recent advances and opportunities for dementia research.
More evidence that presynaptic tau may spread from neuron to neuron.
Mendelian randomization identified HDL cholesterol and systolic blood pressure as modifiable risk factors.
Arranged in bundles and lattices within a plaque, Aβ42 fibrils were intermixed with extracellular vesicles of different shapes and sizes. Their origin remains unknown.
Not everyone with amyloid plaques quickly progresses to symptomatic Alzheimer’s. New research blames astrocytes for driving disease progression. In three observational cohorts, plaque load correlated with p-tau and tangles only in people whose plasma GFAP was high. Does GFAP hold potential as a prognostic biomarker?
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