Damage to the Gut Mucosa May Almost Double Parkinson's Risk
A retrospective study finds that gut damage precedes Parkinson’s disease onset, independent of bacterial infection.
NEWS
Could “Big Tau” Protect Brain Regions from Tangles?
This super-sized isoform resists phosphorylation and aggregation, and occurs in cerebellum and brainstem, regions largely spared from tau pathology.
A Country Doctor, But Oh So Much More: Francisco Lopera, 73
The indefatigable Colombian neurologist leaves behind a legacy of Alzheimer’s prevention research, which, at the time of his passing, stands on the cusp of success.
Nix Tryptophan Metabolite, Temper Alzheimer’s?
Kynurenine curbs lactate production in astrocytes, which then fail to nourish neurons. Shutting down kynurenine production rescued cognition in AD mouse models.
CSF Proteomics Hints at How ApoE4 Promotes AD, and How a Drug Hinders It
Pathways of autophagy, ubiquitination, endocytosis, and glycolysis changed in Alzheimer’s. Treatment with the drug atomoxetine normalized some of them.
Among Icelanders, Blood Proteome Predicts Dementia, Parses Role of ApoE4
The plasma concentration of some 300 proteins foretold dementia. Fewer than half of the proteins were connected to Alzheimer’s independently of ApoE.
That Retrotransposon in TMEM106b: Friend or Foe?
How—or even if—a newly spotted AluYb8 element raises risk of neurodegenerative disease has become a question of intense interest. Centenarians, it seems, are spared.
Questions, Questions for Donanemab, Lecanemab
As immunotherapies enter care, scientists explore when to stop them, how amyloid removal relates to cognitive benefit, and whether fluid markers will track both plaque and tangles responses.
SPOTLIGHT
Francisco Lopera, 73
On September 10, Francisco Lopera died of cancer in Medellin, Colombia. He was widely beloved. Lopera helped pioneer prevention trials of disease-modifying drugs after years spent assembling information on the world’s largest known kindred of autosomal-dominant Alzheimer’s disease caused by the E280A Paisa mutation in presenilin 1.
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