Among AD Mutations, Only ApoE4 Seems to Hobble Microglia
In induced human microglia, the E4 allele profoundly affected their health and cellular responses, while familial Alzheimer’s mutations had little effect.
NEWS
End of the BACE Inhibitors? Elenbecestat Trials Halted Amid Safety Concerns
Biogen and Eisai announced the discontinuation of the Phase 3 program. Elenbecestat was the only remaining BACE inhibitor being tested for AD.
Results of Ladostigil Trial Published
The Phase 2 study missed its primary endpoint. While fewer developed dementia in the treatment group, the effect was not statistically significant. People on drug had less brain atrophy than those on placebo.
Tiny Brain Structure Plays Big Role in Memory
New data strengthen the idea that a healthy locus coeruleus keeps memory sharp into old age.
Hello Mitochondriomics: Tagging Method Identifies Different Subtypes
The organelles express unique sets of proteins depending on their environment. Astrocyte mitochondria process lipids better than those in neurons.
PET Identifies Tangles Decades after a Single Traumatic Brain Injury
The pattern varied from person to person, depending on the site of injury, in contrast to the stereotyped distribution of tau tangles seen in Alzheimer’s disease.
Can Induced Neurons Identify Early Signs of Neurodegeneration?
In patient-derived neurons, tau mutations scupper lysosomes and SORLA shunts APP through different types of endosomes.
Islands of Tau Coat and Protect Cytoskeleton
The protein forms cohesive rafts along microtubules, protecting them from digestion and regulating movement of molecular motors.
Virtual Exhibit Hall
Alzforum encourages users to visit the Virtual Exhibit Hall, where companies showcase their newest initiatives, products, and services. We welcome F. Hoffmann-La Roche, joining our other exhibitors — Biogen, BioLegend, Dash Genomics, Inc., Abcam, BrainXell, and the Jackson Laboratory.
SPOTLIGHT
Hello Mitochondriomics: Tagging Method Identifies Different Subtypes
Mitochondria aren’t all created equal. A new study suggests that the organelles marshal cell-specific proteomes and carry out cell-specific functions. Initial findings from “MitoTag” mice identify mitochondrial proteins unique to different neuronal subtypes and to glia. These markers seem scarce around Aβ plaques and in the spinal cords from ALS patients. MitoTag mice may facilitate studies of mitochondrial dysfunction in neurodegenerative diseases.
Tau Hot Spots Cradle Microtubules, Regulate Transport
Tau undergoes liquid-liquid phase separation to form droplets in solution. New data suggests that a similar condensation occurs along microtubules, where tau self-associates to wrap around stretches of the filaments. These dense tau islands impede some molecular motors that trundle up and down microtubules, but allow others to pass. The islands also protect against two enzymes notorious for severing microtubules. The results suggest condensation is part of tau’s normal, everyday function.
Join The Conversation
Professional Resources
New in last 7 days
-
Grants
- New Items: 6
- Total Items: 423
-
Jobs
- New Items: 5
- Total Items: 89
-
Conference Calendar
- New Items: 1
- Total Items: 31
- Member Directory
Latest Comments