Dystrophic Neurites Dampen Long-Range Neuronal Signaling
These axonal swellings block action potentials, weakening neural networks in mice. PLD3, an Alzheimer’s disease risk gene, may be involved.
NEWS
Finally, a Biomarker to Distinguish Primary Tauopathies?
In two primary tauopathies, fragments containing tau’s microtubule-binding region drop in the CSF as they accumulate in the brain.
Bassoon Heralds Spread of Toxic Tau
Knocking down the synaptic scaffolding protein in mice eased neurofibrillary tangles, gliosis, and neurodegeneration.
Rare Variants in Lipid Transporter Genes Increase Risk for Alzheimer’s Disease
Along with previously identified rare variants in TREM2, SORL1, and ABCA7, a massive exome sequencing effort identified variants in ATP8B4 and ABCA1.
Piezo1 Steers Microglia Toward Rigid Aβ Plaques
Without this mechanosensor, microglia slowly respond to plaques. In mice, a Piezo1 agonist bolstered plaque containment and lowered amyloid burden.
Meddling Medin: A Vascular Amyloid That Promotes CAA?
In mice, this glycoprotein fragment accelerated amyloid deposition in cerebral blood vessels; in people, higher levels correlated with faster cognitive decline and greater AD risk.
Sans TREM2, ApoE4 Drives Microgliosis and Atrophy in Tauopathy Model
Phospho-tau and tangles accumulated, microglia bloated with lipids, and the brain atrophied in these mice.
Gantenerumab Falls Short in Phase 3
The antibody removed less plaque than expected and did not slow cognitive decline, according to top-line data. Detailed data to come at CTAD.
SPOTLIGHT
Bassoon Heralds Spread of Toxic Tau
What drives tau aggregation? The synaptic protein Bassoon, according to scientists. Complexes of Bassoon and tau oligomers seed tangles. In a mouse model of tauopathy, knocking down Bassoon alleviated tau spreading, gliosis, and neurodegeneration. These findings suggest that nipping Bassoon-tau interactions in the bud may quell pathological tau seeding.
Join The Conversation
Professional Resources
New in last 7 days
-
Grants
- New Items: 4
- Total Items: 548
-
Jobs
- New Items: 6
- Total Items: 53
-
Conference Calendar
- New Items: 5
- Total Items: 82
- Member Directory
Latest Comments