New Antibody Binds to Mid-Region, and Aggregates, of Tau
X-ray crystallography yields high-resolution structure.
NEWS
Getting Between Fibrin and Complement Receptor Cools Inflammation
An antibody that binds fibrin blocks neuro-inflammatory signaling while allowing normal clotting.
Across Time and Space: Machine Learning Reveals Paths to Dementia
Analysis of MRI brain volume data identifies multiple AD and FTD/ALS disease subtypes with distinct patterns of degeneration over time.
High-Resolution Map of Hippocampus Reveals Multiple Subnetworks
The most detailed look yet at hippocampal wiring may guide future functional studies and disease research.
ALS on a Chip—A Model for Screening Therapeutics?
Neuromuscular junctions between human stem cell-derived motor neurons and skeletal muscle fibers faltered when cells came from an ALS patient.
Crystal Structure of Aβ and Proposed Receptor Solved
A small molecule that protects neurons fends off a short region of Aβ from a specific pocket on the LilrB2 receptor.
Mixed Messages: mRNA Splicing Errors May Promote Alzheimer’s
A large-scale expression study finds mis-splicing of a specific set of genes in AD brain that includes several known risk genes.
Intelligence Matters More for Brain Reserve, but Education Helps
Longitudinal and genetic studies reveal that intelligence underlies cognitive reserve.
Virtual Exhibit Hall
Alzforum has launched a Virtual Exhibit Hall, a place for companies to showcase their initatives, products, and services. We welcome our exhibitors - Biogen, BioLegend, NanoString Technologies, Inc., Dash Genomics, Inc., and The Jackson Laboratory and encourage our readers to explore their virtual booths here.
SPOTLIGHT
Disentangling Dementias
A new machine-learning technique identifies three subtypes of Alzheimer’s disease and four of frontotemporal dementia based on their unique patterns of brain atrophy over time. In FTD, the subtypes tracked with disease-causing genetic mutations, while in AD, the three major subtypes helped predict the risk of clinical progression from mild cognitive impairment to dementia. The method, which the authors call SuStaIn, for Subtype and Stage Inference, could help with selection of candidates for clinical trials, and eventually with precision-medicine approaches to dementia.
High-Resolution Map of Hippocampus Reveals Multiple Subnetworks
Get ready to rethink the hippocampus. Under detailed, cellular-level analysis of gene expression and axonal tracts, its six anatomical parts subdivide into 22 distinct regions, each with a unique pattern of connectivity to other hippocampal regions and the rest of the brain. The data will provide researchers with new tools to investigate hippocampal function in health and disease.
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