Mutant Tau Stiffens Axon Cytoskeleton Near Soma
In neurons derived from FTD patients, morphological changes at the base of the axon render them hyperexcitable.
NEWS
In Mice and Men, Prostate Drug Reportedly Treats Parkinson’s Disease
In animal models and patient-derived neurons, terazosin elevated ATP and warded off neurodegeneration. Men who take the drug to control prostate hyperplasia are less likely to get PD, or have milder symptoms.
Phase 3 Trial Suggests Pimavanserin Assuages Psychosis in Dementia
The study halted early when the primary endpoint was met, but an unusual trial design and lack of detailed data leave questions unanswered.
Chris Dobson, Master of Protein Folding Research, Dies at 69
A chemist at the University of Cambridge, Dobson developed equations that described the kinetics of protein aggregation in diseases such as Alzheimer’s.
Among AD Mutations, Only ApoE4 Seems to Hobble Microglia
In induced human microglia, the E4 allele profoundly affected their health and cellular responses, while familial Alzheimer’s mutations had little effect.
End of the BACE Inhibitors? Elenbecestat Trials Halted Amid Safety Concerns
Biogen and Eisai announced the discontinuation of the Phase 3 program. Elenbecestat was the only remaining BACE inhibitor being tested for AD.
Results of Ladostigil Trial Published
The Phase 2 study missed its primary endpoint. While fewer developed dementia in the treatment group, the effect was not statistically significant. People on drug had less brain atrophy than those on placebo.
Tiny Brain Structure Plays Big Role in Memory
New data strengthen the idea that a healthy locus coeruleus keeps memory sharp into old age.
Virtual Exhibit Hall
Alzforum encourages users to visit the Virtual Exhibit Hall, where companies showcase their newest initiatives, products, and services. We welcome F. Hoffmann-La Roche, joining our other exhibitors — Biogen, BioLegend, Dash Genomics, Inc., Abcam, BrainXell, and the Jackson Laboratory.
SPOTLIGHT
Hello Mitochondriomics: Tagging Method Identifies Different Subtypes
Mitochondria aren’t all created equal. A new study suggests that the organelles marshal cell-specific proteomes and carry out cell-specific functions. Initial findings from “MitoTag” mice identify mitochondrial proteins unique to different neuronal subtypes and to glia. These markers seem scarce around Aβ plaques and in the spinal cords from ALS patients. MitoTag mice may facilitate studies of mitochondrial dysfunction in neurodegenerative diseases.
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