Does Oleic Acid Hold the Key to α-Synuclein Toxicity?
In several model systems, α-synuclein boosts oleic acid production and the fatty acid worsens α-synuclein pathology.
NEWS
First Round of Awards from Chan Zuckerberg Initiative Announced
The awards total $52 million, divided among 17 early career investigators and nine collaborative science teams.
Neurofilament Light: A Universal Mark of Neurodegeneration
In patients across a range of neurodegenerative diseases, NfL ramps up in the cerebrospinal fluid. Levels are higher in those with worse disease.
A Proteomics Dive into Cause of Frontotemporal Dementia
Proteomics and protein-protein interaction research may yield clues to etiology, tracking, and treatment of granulin-related and other forms of FTD/ALS.
Tracking Onset and Progression of Frontotemporal Dementia
New scales debuted at ICFTD could help clinical trials.
Natural History Studies Provide Foundation for FTD Research
At ICFTD in Sydney, researchers update the community on ARTFL/LEFFTDS.
11th ICFTD Meeting in Sydney Sorts Out Clinical Subtypes
Can genetics please parse the confusing spectrum of frontotemporal dementias? Whole genome sequences make a start.
Going the Distance: FUS Travels to Terminals, Drops Off RNA
Scientists say chaperones keep FUS from joining up with aggregating proteins as FUS makes its way down axons to deliver RNAs for local translation. ALS/FTD mutations bungle the process.
Virtual Exhibit Hall
Alzforum encourages users to visit the Virtual Exhibit Hall, where companies showcase their newest initiatives, products, and services. We welcome Dash Genomics, Inc. and Abcam, which join our other exhibitors — Biogen, BioLegend, NanoString Technologies, Inc., and the Jackson Laboratory.
SPOTLIGHT
Sydney Conference Underscores Heterogeneity of FTD
Encompassing more than half dozen subtypes, linked to at least four different protein aggregates and at least six distinct genes, frontotemporal dementia would seem like a researcher’s nightmare. And yet, its science is advancing so fast that they have never been more hopeful. Read Tom Fagan’s coverage of the 11th International Congress on FTD, held in Sydney, to catch up on the news.
RNA Metabolism Field Gels at 5th Meeting
When RNA transcripts aren’t processed properly or don’t make it to their final destinations for translation into protein, the consequences could trigger neurodegenerative disease. At the 5th RNA Metabolism in Neurological Disease meeting, researchers reported how RNA-binding proteins tasked with keeping transcripts in order manage to fall out of line themselves—gelling with other proteins and RNA in cytoplasm. Scientists linked previously disparate mechanisms of C9ORF72 toxicity into cohesive feed-forward loops, and hatched plans for new therapeutic approaches.
Imaging Data Resurrects Abandoned Parkinson’s Gene Therapy
Brain scans can show you not only what goes wrong in disease, but also what goes right in treatment. In the case of a sidelined Parkinson’s gene therapy, FDG PET scans now reveal that it sparked a new functional brain network. The strength of this network correlated with clinical improvement. The data have renewed interest in developing the therapy.
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