Using chemical cross-linkers to map contacts among amino acids, structural biologists predict that soluble tau is, in fact, a compact globule containing β-sheets poised to snap into a pathological formation.
Ablating the immune cells protected mouse models of frontotemporal dementia from the neurodegeneration caused by human ApoE4.
Resident T cells in the membrane surrounding the healthy mouse brain influence both short-term memory and synaptic plasticity.
The protein helps internalize neuronal interleukin receptors. It also promotes microglial phagocytosis. Does its absence worsen neuroinflammation and Aβ burden?
Researchers induced cortical organoids to grow their own vasculature and even form a blood-“brain” barrier, making the little blobs more useful for studying disease.
Overexpressing neuronal A2A receptors stoked C1q in microglia, damaging synapses and memory.
The circular transcripts correlate with AD pathology and dementia severity, suggesting potential roles in pathogenesis or as biomarkers.
A new study argues that the duration of a person’s amyloid positivity predicts whether they’ll develop tau accumulation and cognitive decline.
Alzforum encourages users to visit the Virtual Exhibit Hall, where companies showcase their newest initiatives, products, and services. We welcome F. Hoffmann-La Roche, joining our other exhibitors — Biogen, BioLegend, Dash Genomics, Inc., Abcam, BrainXell, and the Jackson Laboratory.
Pea-sized clumps of cortical cells grown in a dish mimic some aspects of the brain, but without a vascular system, neurons inside these organoids get sick and die. Now, scientists have found a way to encourage blood vessels to grow in these little blobs, which keeps the neurons healthy for months. Conveniently, cells lining the vessels form tight junctions, similar to those of the blood-brain barrier. The vascularized organoids could enable in vitro study of barrier function, researchers believe.
In the crazy world of regulatory RNA, nothing seems more puzzling than circular transcripts. These stable loops have mostly been studied in cancer, but in this week’s Nature Neuroscience, scientists at Washington University report that some circular RNAs correlate with Alzheimer’s disease pathology and clinical severity. The findings hint at potential biomarkers or even therapeutic targets.
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