Map of Human Vascular Expression Highlights its Potential Role in Alzheimer’s
The first detailed look at expression profiles in blood vessels of the human brain identifies new cell subtypes. These cells express 30 of the top 45 AD risk genes.
NEWS
New Knock-In Mice Rapidly Accumulate Amyloid Plaques
The APP/PS1 double knock-ins begin to deposit amyloid in the brain by 3 months of age.
iNDI Aims to Standardize Human Stem Cell Research
The iPSC Neurodegenerative Disease Initiative is creating 100+ isogenic cell lines. Each carries a different risk variant for Alzheimer's or a related dementia. Scientists around the world can obtain the cells through Jackson Labs.
Forget Typical Alzheimer's: AI Finds Four Types.
Machine learning analysis of 912 PET scans says neurofibrillary tangles spread through the AD brain in one of four distinct patterns.
Does Anti-Amyloid Immunotherapy Need the Lymphatic System?
The fewer their meningeal lymphatic vessels, the slower treated mice clear plaques. Lymphatic dysfunction also drives microglial activation, hinting at a role in pathology.
Diabetes in Mid-Life Drives Up Dementia Risk
People who develop Type 2 diabetes before age 60 have more than double the dementia risk, and earlier dementia onset, than those without diabetes.
Sans Nuclear TDP-43, Splicing of An ALS/FTD Gene Goes Awry
Incorporation of a cryptic exon scuttles translation of UNC13A, but only in neurons lacking nuclear TDP-43. UNC13A ALS/FTD risk variants exacerbate the aberrant splicing.
Bio-Hermes: Making Alzheimer’s Diagnosis Fast, Cheap, Accessible
A new trial will compare digital and blood-based biomarkers to amyloid PET scans in order to learn which ones best pick out early plaque accumulation.
Virtual Exhibit Hall
Alzforum encourages users to visit the Virtual Exhibit Hall, where companies showcase their newest initiatives, products, and services. We welcome F. Hoffmann-La Roche, joining our other exhibitors — Biogen, BioLegend, Abcam, BrainXell, and the Jackson Laboratory.
SPOTLIGHT
Mapping Human Vascular Expression and its Links to AD
Encased in fibrous blood vessels, brain vascular cells are tough nuts to crack. Now, researchers have devised a way to break up the vascular material to release single nuclei for RNA sequencing. Their first map of gene expression in the human brain vasculature found differences as the vessels morphed from arteries to capillaries to veins. Some surprises included two distinct types of pericyte and two fibroblasts. Notably, vascular cells express 30 of the top 45 AD risk genes, hinting at a larger role for the vasculature in pathogenesis than had been thought.
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