The Tau Pipeline Enabling Program (T-PEP)

GRANT Saturday, August 17, 2019- 20:45 Alzheimer's Association and Tau Consortium Up to $750,000 LOI Deadline: September 12, 2019, 5 p.m. ET The Tau Pipeline Enabling Program (T-PEP) ...

PAPER TCW J, Liang SA, Qian L, Pipalia NH, Chao MJ, Shi Y, Bertelsen SE, Kapoor M, Marcora E, Sikora E, Holtzman DM, Maxfield FR, Zhang B, Wang M, Poon WW, Goate AM

Cholesterol and matrisome pathways dysregulated in human APOE ε4 glia

bioRχiv, July 25, 2019

Tenure-Track Faculty Positions in Neuroscience

JOB 2019-08-17 Employer University of Maryland School of Medicine Contact Candidates should submit the following as a single PDF to  facsearch@umaryland.edu: Curriculum vitae, brief statement of research interests and goals, and contact information for three references. ...

Tenure-Track Faculty Positions

JOB 2019-08-17 Employer University of Maryland School of Medicine Contact Candidates should submit the following as a single PDF to  facsearch@umaryland.edu: Curriculum vitae, brief statement of research interests and goals, and contact information for three references. ...

Regenerative Medicine Innovation Project (RMIP) Investigator-Initiated Clinical Trials (UG3/UH3 Clinical Trial Required) (RFA-HL-20-030)

GRANT Saturday, August 17, 2019- 07:45 National Institutes of Health NIH intends to commit total costs of up to $3,118,000 in fiscal 2020. These funds are anticipated to fund up to five new awards in fiscal 2020. October 18, 2019 No late applications will be ...

Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Institutionally-Focused Research Education Award to Promote Diversity (UE5- Clinical Trial Not Allowed) (PAR-19-342)

GRANT Saturday, August 17, 2019- 07:30 National Institute of General Medical Sciences November 15, 2019; November 2, 2020, by 5 p.m. local time of applicant organization. Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) ...

Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (K99/R00- Independent Clinical Trial Not Allowed) (PAR-19-343)

GRANT Saturday, August 17, 2019- 07:30 National Institute of General Medical Sciences Standard dates apply, by 5 p.m. local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on these ...

Research Education: Short Courses on Alzheimer's Disease and Related Dementias for the Behavioral and Social Sciences (R25 Clinical Trial Not Allowed) (RFA-AG-20-031)

GRANT Saturday, August 17, 2019- 07:30 National Institute on Aging NIA intends to commit $495,000 in total costs in FY 2020 to fund three awards. January 21, 2020, by 5 p.m. local time of the applicant organization. Research Education: Short Courses on ...

Jan Peterson

Baystate Medical Practices
Turners Falls, United States

Selina Wray, Charlie Arber on Familial AD Mutations, ß-CTF, Spell Trouble for Endosomes

COMMENT Induced pluripotent stem cell (iPSC)-derived cell types are widely used as physiologically-relevant models of human neurodegenerative disease, but challenges still remain around the inherent variability driven largely by differing genetic backgrounds.  A ...

Christian Haass on Familial AD Mutations, ß-CTF, Spell Trouble for Endosomes

COMMENT This paper reproduces findings in human iPSC-derived neurons that others made decades ago in much simpler cell systems.  These cell lines are therefore a nice and important resource for future research, but I would have expected a balanced discussion and ...

Rick Livesey on Familial AD Mutations, ß-CTF, Spell Trouble for Endosomes

COMMENT Pioneering work from several groups, most notably from Ralph Nixon and colleagues, identified dysfunction of the endolysosomal network in Alzheimer’s disease, and that this was due to abnormal processing of APP.  This exciting study is an important ...

Rik van der Kant on Familial AD Mutations, ß-CTF, Spell Trouble for Endosomes

COMMENT This is a very impressive and exhaustive study by the Tessier-Lavigne lab showing that APP β-CTFs, but not Aβ, drives endosomal enlargement in human neurons from patients with familial AD (FAD). Using more than fifteen isogenic iPSC lines, the authors ...

Ralph Nixon on Familial AD Mutations, ß-CTF, Spell Trouble for Endosomes

COMMENT This report on CRISPR-modified IPSC neurons expressing diverse APP and PSEN1 FAD mutations is a technical tour de force. It is a welcome confirmation of our previous findings on neurons in AD, FAD, and Down’s Sydrome (DS) brains and human DS fibroblasts, ...

PAPER Growcott EJ, Bamba D, Galarneau JR, Leonard VH, Schul W, Stein D, Osborne CS

The effect of P38 MAP kinase inhibition in a mouse model of influenza.

J Med Microbiol. 2018 Mar;67(3):452-462. Epub 2018 Jan 24 PubMed: 29458547