Genomic Expert Curation Panels (U24 Clinical Trial Not Allowed) (PAR-20-101)

GRANT Friday, January 24, 2020- 16:30 National Institutes of Health May 27, 2020; May 27, 2021; May 27, 2022 Genomic Expert Curation Panels (U24 Clinical Trial Not Allowed) (PAR-20-101) ...

Harmonization of Alzheimers Disease and Related Dementias (AD/ADRD) Genetic, Epidemiologic, and Clinical Data to Enhance Therapeutic Target Discovery (U24 Clinical Trial Not Allowed) (PAR-20-099)

GRANT Friday, January 24, 2020- 16:30 National Institute on Aging Standard dates apply. The first standard due date for this FOA is May 25, 2020 Harmonization of Alzheimers Disease and Related Dementias (AD/ADRD) Genetic, Epidemiologic, and Clinical Data to ...

Alexander Drzezga on Connectivity, Not Proximity, Predicts Tau Spread

COMMENT This work by Franzmeier and colleagues is an elegant study that further illuminates the relationship between tau deposition and the functional network architecture of the brain. A particularly interesting outcome of the work lies in the discovery of a ...

Connectivity, Not Proximity, Predicts Tau Spread

RESEARCH NEWS 2020-01-24 Research News The idea that tau pathology creeps through the brain via neural circuitry may have gained its strongest support yet from a study published January 17 in Nature Communications. Drawing on longitudinal tau PET imaging data from ADNI and ...

Virgil Muresan on With a Shot of Adrenaline, Amyloid-β Sparks Tau Cascade

COMMENT Different regions of the brain are differentially affected by plaque and tangle pathology, with the cerebral cortex and hippocampus being the primary targets. Subcortical regions are also affected. The noradrenergic locus coeruleus (LC) is involved in the ...

Richard McCulloch

Postdoctoral Researcher

JOB 2020-01-24 Employer Beth Israel Hospital Description A postdoctoral fellow position is available immediately in the Department of Pathology at Harvard Medical School/Beth Israel Deaconess Medical Center to study resilience in Alzheimer’s disease. The position is ...

Amaia Dominguez Belloso

Frankfurt am Main, Germany

Is Too Much Vitamin B12 a Health Hazard?

RESEARCH NEWS 2020-01-24 Research News Vitamin B12 is a commonly used supplement and has been tested as a preventive treatment for Alzheimer’s disease, but could too much of it be bad for you? In the January 3 JAMA Network Open, scientists led by Jose Flores-Guerrero and Stephan ...

Lorenzo Cipriano

Università della Campania Luigi Vanvitelli
Caserta, Italy

Lea T. Grinberg on With a Shot of Adrenaline, Amyloid-β Sparks Tau Cascade

COMMENT The paper shows a series of logically linked experiments using human brain tissue, wild-type mice, two lines of mice producing excessive Aβ, and neuronal cultures. It demonstrates that Aβ oligomers can bind allosterically to α 2A AR receptors of the ...

Mikael Simons on Human and Mouse Microglia React Differently to Amyloid

COMMENT This is an excellent study providing new insights and a rich resource on TREM2-dependent glial responses in AD in mice and humans. One highlight of the study is the description of reactive oligodendrocytes in the 5xFAD mouse model of AD. Using snRNAseq, ...

PAPER Mendonça N, Jagger C, Granic A, Martin-Ruiz C, Mathers JC, Seal CJ, Hill TR

Plasma Vitamin B12, Supplementation and Mortality.

J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):138. PubMed: 30165591

PAPER Flores-Guerrero JL, Minovic I, Groothof D, Gruppen EG, Riphagen IJ, Kootstra-Ros J, Muller Kobold A, Hak E, Navis G, Gansevoort RT, de Borst MH, Dullaart RP, Bakker SJ

Association of Plasma Concentration of Vitamin B12 With All-Cause Mortality in the General Population in the Netherlands.

JAMA Netw Open. 2020 Jan 3;3(1):e1919274. PubMed: 31940038

PAPER Cappello S, Cereda E, Rondanelli M, Klersy C, Cameletti B, Albertini R, Magno D, Caraccia M, Turri A, Caccialanza R

Elevated Plasma Vitamin B12 Concentrations Are Independent Predictors of In-Hospital Mortality in Adult Patients at Nutritional Risk.

Nutrients. 2016 Dec 23;9(1) PubMed: 28025528