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Julio Rojas on Proteomics Lays Groundwork for FTD Biomarkers

COMMENT This is an important study for fluid biomarker development in FTD. The results could support further diagnostic and therapeutic development in FTD, a condition with no cure and for which no specific diagnostic test exist. The study in this European cohort

Agustin Ibanez on Proteomics Lays Groundwork for FTD Biomarkers

COMMENT This is a very impactful paper. The authors found distinct and shared proteomic alterations across genetic FTD subtypes. Each genetic FTD mutation (C9ORF72, GRN, MAPT) displayed unique CSF proteomic changes. Some proteins were altered across all three sub

Proteomics Lays Groundwork for FTD Biomarkers

RESEARCH NEWS 2025-02-09 Research News Scientists are urgently seeking fluid biomarkers for frontotemporal dementia, the most common dementing illness among 40- and 50-year-olds. Two large collaborations studying genetic FTD cohorts have now cracked open the door. In one, scienti

David Weisman on Leqembi Maintenance Dosing Approved in the U.S.

COMMENT As a practical matter, this is wonderful news for our practice. We currently have about 10 people who will adopt this dose and many to follow. This frees us up to accommodate new doses, help more people, and provides a goal which is sure to help discussio

Expunging Microglial Lipid Droplets Boosts Phagocytosis

RESEARCH NEWS 2025-02-07 Research News In Alzheimer’s disease, microglia pack on fat, which impairs phagocytosis. Now, scientists led by Christiane Ruedl of Nanyang Technological University, Singapore, report that blocking lipid buildup in these cells restores their capacity to e

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