Therapeutics
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| Name | Synonyms | FDA Status | Company | Target Type | Therapy Type | Approved For |
|---|---|---|---|---|---|---|
| RO7105705 | MTAU9937A, RG6100 |
Alzheimer's Disease (Phase 2) | AC Immune SA, Genentech, Hoffmann-La Roche | Tau | Immunotherapy (passive) | |
| AAB-003 | PF-05236812 | Alzheimer's Disease (Discontinued) | Janssen, Pfizer | Amyloid-Related | Immunotherapy (passive) | |
| AADvac-1 | Axon peptide 108 conjugated to KLH | Alzheimer's Disease (Phase 2), Progressive Nonfluent Aphasia (Phase 1) | Axon Neuroscience SE | Tau | Immunotherapy (active) | |
| ABT 418 | Alzheimer's Disease (Discontinued) | Cholinergic System | Small Molecule | None | ||
| ABT-089 | Alzheimer's Disease (Discontinued) | Abbott Laboratories | Cholinergic System | Small Molecule | ||
| ABT-288 | Alzheimer's Disease (Discontinued) | AbbVie | Cholinergic System, Other Neurotransmitters | Small Molecule | ||
| ABT-384 | Alzheimer's Disease (Discontinued) | AbbVie | Other | Small Molecule | ||
| ABT-957 | Alzheimer's Disease (Phase 1) | AbbVie | Other | Small Molecule | ||
| ABvac 40 | Alzheimer's Disease (Phase 2) | Araclon Biotech | Amyloid-Related | Immunotherapy (active) | ||
| ACI-24 | Pal1-15 acetate salt | Alzheimer's Disease (Phase 1/2), Down's Syndrome (Phase 1) | AC Immune SA | Amyloid-Related | Immunotherapy (active) | |
| ACI-35 | Alzheimer's Disease (Phase 1) | AC Immune SA, Janssen | Tau | Immunotherapy (active) | ||
| AF 102B | cevimeline HCL, Evoxac™ |
Alzheimer's Disease (Discontinued) | SnowBrand Pharmaceuticals, Inc. | Cholinergic System | Small Molecule | Treatment of dry mouth in Sjogren's syndrome. |
| AGB101 | Levetiracetam, Keppra |
Mild Cognitive Impairment (Phase 3), Parkinson's Disease (Discontinued) | AgeneBio, Inc. | Amyloid-Related, Other | Small Molecule | Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries |
| AL001 | Frontotemporal Dementia (Phase 1) | Other | Immunotherapy (passive) | |||
| AL002 | Alzheimer's Disease (Phase 1) | AbbVie, Alector | Inflammation | Immunotherapy (active) | ||
| AL003 | Alzheimer's Disease (Phase 1) | AbbVie, Alector | Inflammation | Immunotherapy (active) | ||
| ALZT-OP1 | Cromolyn sodium, Intal, Ibuprofen |
Alzheimer's Disease (Phase 3) | AZTherapies, Inc. | Amyloid-Related, Inflammation | Small Molecule | |
| AN-1792 | AIP 001 | Alzheimer's Disease (Discontinued) | Janssen, Pfizer | Amyloid-Related | Immunotherapy (active) | None |
| AVP-786 | Alzheimer's Disease (Phase 3), Schizophrenia (Phase 2) | Avanir Pharmaceuticals, Concert Pharmaceuticals, Inc., Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Small Molecule | ||
| AVP-923 | Nuedexta, Zenvia |
Alzheimer's Disease (Phase 4), Amyotrophic Lateral Sclerosis (Phase 3), Parkinson's Disease (Phase 3) | Avanir Pharmaceuticals | Other Neurotransmitters | Small Molecule | |
| AZD1446 | TC-6683 | Alzheimer's Disease (Discontinued) | AstraZeneca, Targacept | Cholinergic System | Small Molecule | None |
| AZD3480 | ispronicline, TC-1734 |
Alzheimer's Disease (Inactive) | AstraZeneca, Targacept | Cholinergic System | Small Molecule | |
| Acetyl-l-carnitine HCI | ALCAR | Alzheimer's Disease (Discontinued) | Sigma-Tau Pharmaceuticals | Other | Dietary Supplement | |
| Acitretin | Soriatane , Neotigason, RO 101670 |
Alzheimer's Disease (Phase 2) | Actavis, Allergan plc | Amyloid-Related | Small Molecule | Psoriasis in US |
| Aducanumab | BIIB037 | Alzheimer's Disease (Discontinued) | Biogen, Neurimmune | Amyloid-Related | Immunotherapy (passive) | |
| Affitope AD02 | Alzheimer's Disease (Phase 2) | AFFiRiS AG | Amyloid-Related | Immunotherapy (active) | ||
| Allopregnanolone | 3α,5α-tetrahydroprogesterone, 3α-hydroxy-5α-pregnan-20-one |
Alzheimer's Disease (Phase 1) | Other Neurotransmitters, Other | Small Molecule | ||
| Alpha-Tocopherol | Vitamin E | Alzheimer's Disease (Phase 3) | Other | Dietary Supplement | ||
| Alzhemed™ | Vivimind™, Tramiprosate, NC-531, homotaurine, 3-APS |
Alzheimer's Disease (Inactive) | Neurochem, Inc. | Amyloid-Related | Dietary Supplement | None |
| Anavex 2-73 | Alzheimer's Disease (Phase 2) | Anavex Life Science Corp. | Other | Small Molecule | ||
| Apabetalone | RVX208, RVX000222 |
MCI-VaD (Phase 3) | Resverlogix Corporation | Other | Small Molecule | |
| Aripiprazole | Abilify, BMS-337039 |
Alzheimer's Disease (Phase 3), Schizophrenia (Approved) | Bristol-Myers Squibb, Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Small Molecule | |
| Atabecestat | JNJ-54861911 , BACE inhibitor |
Alzheimer's Disease (Discontinued) | Janssen, Shionogi Pharma | Amyloid-Related | Small Molecule | |
| Atomoxetine | ATX, Strattera |
Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Other Neurotransmitters | Small Molecule | ADHD in US |
| Atorvastatin | Lipitor™ , Zarator®, Sortis®, Tahor® |
Alzheimer's Disease (Inactive) | Pfizer | Cholesterol | Small Molecule | Hypercholesterolaemia |
| Avagacestat | BMS-708163 | Alzheimer's Disease (Discontinued) | Bristol-Myers Squibb | Amyloid-Related | Small Molecule | |
| Azeliragon | PF-04494700 , TTP488 |
Alzheimer's Disease (Inactive) | Pfizer, TransTech Pharma, Inc., vTv Therapeutics LLC | Amyloid-Related, Inflammation | Small Molecule | |
| BAN2401 | mAb158 | Alzheimer's Disease (Phase 3) | Biogen, Eisai Co., Ltd. | Amyloid-Related | Immunotherapy (passive) | |
| BI 1181181 | VTP 37948, BACE inhibitor |
Alzheimer's Disease (Discontinued) | Boehringer Ingelheim, Vitae Pharmaceuticals | Amyloid-Related | Small Molecule | |
| BI 409306 | SUB 166499 | Alzheimer's Disease (Discontinued), Schizophrenia (Phase 2) | Boehringer Ingelheim | Other Neurotransmitters, Other | Small Molecule | |
| BI 425809 | Alzheimer's Disease (Phase 2), Schizophrenia (Phase 2) | Boehringer Ingelheim | Other Neurotransmitters | Small Molecule | ||
| BIIB054 | NI-202 | Parkinson's Disease (Phase 2) | Biogen, Neurimmune | alpha-synuclein | Immunotherapy (passive) | |
| BIIB076 | NI-105, 6C5 huIgG1/l |
Alzheimer's Disease (Phase 1) | Biogen, Neurimmune | Tau | Immunotherapy (passive) | |
| BIIB080 | IONIS-MAPTRx, ISIS 814907 |
Alzheimer's Disease (Phase 1) | Biogen, IONIS Pharmaceuticals | Tau | RNA-based | |
| BIIB092 | BMS-986168, IPN007 | Progressive Supranuclear Palsy (Phase 2), Alzheimer's Disease (Phase 2) | Biogen, Bristol-Myers Squibb | Tau | Immunotherapy (passive) | |
| Bapineuzumab | AAB-001 | Alzheimer's Disease (Discontinued) | Janssen, Pfizer | Amyloid-Related | Immunotherapy (passive) | |
| Besipirdine HCl | HP 749 | Alzheimer's Disease (Discontinued) | Aventis Pharmaceuticals, Inc. (was Hoechst) | Other Neurotransmitters | Small Molecule | |
| Bexarotene | Targretin® | Alzheimer's Disease (Phase 2) | Ligand Pharmaceuticals, Inc., ReXceptor Inc. | Amyloid-Related, Unknown | Small Molecule | Cutaneous T-cell Lymphoma in US |
| Brexpiprazole | Rexulti, OPC 34712 |
Alzheimer's Disease (Phase 3), Schizophrenia (Approved) | H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Small Molecule | |
| C2N 8E12 | ABBV-8E12 | Progressive Supranuclear Palsy (Phase 2), Alzheimer's Disease (Phase 2) | AbbVie, C2N Diagnostics, LLC | Tau | Immunotherapy (passive) | |
| CAD106 | Alzheimer's Disease (Phase 2/3) | Novartis Pharmaceuticals Corporation | Amyloid-Related | Immunotherapy (active) | None | |
| CERE-110 | Nerve Growth Factor gene therapy | Alzheimer's Disease (Discontinued) | Sangamo BioSciences, Inc. | Other | DNA-based | |
| CHF 5074 | Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Inactive) | CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. | Amyloid-Related, Inflammation, Other | Small Molecule | ||
| COGNIShunt™ | Alzheimer's Disease (Inactive) | Other | Procedural Intervention | None | ||
| COR388 | Alzheimer's Disease (Phase 1) | Cortexyme, Inc. | Other | Small Molecule | ||
| CX516 | Ampalex | Alzheimer's Disease (Discontinued) | Cortex Pharmaceuticals, Inc. | Other Neurotransmitters | Small Molecule | None |
| Carvedilol | Coreg, Artist , Aucardic, Dilatrend, Kredex |
Alzheimer's Disease (Phase 4) | Procter & Gamble | Unknown | Small Molecule | Hypertension, heart failure, angina pectoris |
| Celecoxib | Celebrex | Alzheimer's Disease (Discontinued) | Pfizer | Inflammation | Small Molecule | Pain, Arthritis |
| Cerebrolysin | Alzheimer's Disease (Phase 2) | Ebewe Pharmaceutical | Other | Other | ||
| Circadin | Alzheimer's Disease (Phase 2) | Neurim Pharmaceuticals Ltd. | Other | Small Molecule | Insomnia | |
| Clioquinol | iodochlorhydroxyquin, PBT-1 |
Alzheimer's Disease (Discontinued) | Prana Biotechnology Limited | Amyloid-Related, Metals | Small Molecule | |
| Continuous Positive Airway Pressure | CPAP | Alzheimer's Disease (Phase 3) | Unknown | Procedural Intervention | Sleep Apnea in US | |
| Crenezumab | MABT5102A , RG7412 |
Alzheimer's Disease (Phase 2) | AC Immune SA, Genentech, Hoffmann-La Roche | Amyloid-Related | Immunotherapy (passive) | None |
| Curcumin | diferuloylmethane, Longvida™ |
Alzheimer's Disease (Phase 2) | Verdure Sciences | Other, Unknown | Dietary Supplement | None |
| DNL747 | SAR 443060 | Alzheimer's Disease (Phase 1), Amyotrophic Lateral Sclerosis (Phase 1) | Denali Therapeutics Inc., Sanofi | Inflammation | Small Molecule | |
| Dapsone | Avlosulfon, Diaminodiphenylsulfone, DDS |
Alzheimer's Disease (Inactive) | Immune Network Ltd. | Other | Small Molecule | Leprosy, malaria, some bacterial skin infections |
| Davunetide | NAP, AL-108 |
Mild Cognitive Impairment (Discontinued), Progressive Supranuclear Palsy (Discontinued), Schizophrenia (Discontinued), Frontotemporal Dementia (Inactive) | Allon Therapeutics Inc., Paladin Labs Inc. | Tau | Other | |
| Deep Brain Stimulation-fornix | Alzheimer's Disease (Phase 2) | Functional Neuromodulation Ltd | Unknown | Procedural Intervention | ||
| Dexpramipexole | R-pramipexole, RPPX, KNS-760704 , BIIB 050 |
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) | Biogen, Knopp Biosciences LLC, Virginia Commonwealth University | Other Neurotransmitters, Other | Small Molecule | |
| Dimebon | Dimebolin, Latrepirdine, Pf-01913539 |
Alzheimer's Disease (Discontinued), Huntington's Disease (Discontinued) | Medivation, Inc. | Other Neurotransmitters, Unknown | Small Molecule | Anti-histamine use in Russia |
| Docosahexaenoic acid (DHA) | Omega 3 fatty acid | Alzheimer's Disease (Phase 4) | Martek Biosciences Corporation, NeuroBioPharm, Inc. | Other | Dietary Supplement | |
| Donanemab | N3pG-Aβ Monoclonal Antibody, LY3002813 |
Alzheimer's Disease (Phase 2) | Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | |
| Donepezil | Aricept™, Donepezil hydrochloride, Eranz®, E 2020 |
Alzheimer's Disease (Approved), Dementia with Lewy Bodies (Phase 3), Down's Syndrome (Phase 2), Parkinson's Disease Dementia (Phase 3) | Eisai Co., Ltd., Pfizer | Cholinergic System | Small Molecule | Alzheimer's Disease |
| EHT 0202 | Etazolate | Alzheimer's Disease (Phase 2) | ExonHit Therapeutics | Other | Small Molecule | None |
| ELND005 | AZD-103, Scyllo-inositol, cyclohexane-1,2,3,4,5,6-hexol |
Alzheimer's Disease (Inactive) | Elan Corporation, Opko Health, Speranza Therapeutics, Transition Therapeutics, Inc. | Amyloid-Related | Small Molecule | None |
| EVP-0962 | EVP 0015962 | Alzheimer's Disease (Phase 2), Mild Cognitive Impairment (Phase 2) | FORUM Pharmaceuticals Inc. | Amyloid-Related | Small Molecule | |
| Edonerpic | T-817 MA, T 817 | Alzheimer's Disease (Phase 2) | Toyama Chemical Co., Ltd. | Other, Unknown | Small Molecule | |
| Elayta | CT1812 | Alzheimer's Disease (Phase 2) | Cognition Therapeutics Inc. | Amyloid-Related | Small Molecule | |
| Elenbecestat | E2609, BACE inhibitor |
Alzheimer's Disease (Phase 3) | Biogen, Eisai Co., Ltd. | Amyloid-Related | Small Molecule | |
| Encenicline | EVP-6124 , MT-4666, α7-nAChR agonist |
Alzheimer's Disease (Discontinued), Schizophrenia (Discontinued) | FORUM Pharmaceuticals Inc., Mitsubishi Tanabe Pharma | Cholinergic System | Small Molecule | None |
| Epigallocatechin Gallate (EGCG) | Sunphenon EGCg | Alzheimer's Disease (Phase 2/3), Down's Syndrome (Phase 2), Multiple System Atrophy (Phase 3) | Taiyo International | Amyloid-Related, Inflammation, Other | Dietary Supplement | |
| Epothilone D | BMS-241027 | Alzheimer's Disease (Discontinued) | Bristol-Myers Squibb | Tau | Small Molecule | |
| Eptastigmine | MF 201 | Alzheimer's Disease (Discontinued) | Mediolanum | Cholinergic System | Small Molecule | None |
| Estrogen | Premarin™ | Alzheimer's Disease (Discontinued) | Other | Other | Hormone Replacement Therapy | |
| Etanercept | Enbrel™ | Alzheimer's Disease (Phase 2) | Amgen, Inc., Pfizer | Inflammation | Immunotherapy (passive) | Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondilysis |
| Exendin-4 | Exenatide, Byetta, Bydureon |
Alzheimer's Disease (Inactive), Parkinson's Disease (Phase 2) | Other | Small Molecule | Diabetes mellitus in US | |
| FRM-0334 | EVP-0334 | Frontotemporal Dementia (Phase 2) | FORUM Pharmaceuticals Inc. | Other | Small Molecule | |
| Flurizan™ | tarenflurbil , r-flurbiprofen, MPC-7869 |
Alzheimer's Disease (Discontinued) | Myriad Genetics & Laboratories | Amyloid-Related | Small Molecule | None |
| G-CSF | Filgrastim | Alzheimer's Disease (Phase 2) | Other | Small Molecule | Neutropenia in US | |
| GC 021109 | Alzheimer's Disease (Phase 1) | GliaCure | Inflammation | Small Molecule | ||
| GENUS | Gamma entrainment using sensory stimuli | Alzheimer's Disease (Phase 1) | Cognito Therapeutics, Inc. | Amyloid-Related, Inflammation, Other | Procedural Intervention | |
| GLN-1062 | Memogain | Alzheimer's Disease (Phase 1) | Galantos Pharma, Neurodyn | Cholinergic System | Small Molecule | |
| GM-CSF Leukine | Sargramostim, Leukine® |
Alzheimer's Disease (Phase 2) | Genzyme, Sanofi | Inflammation, Other, Unknown | Other | Bone Marrow Stimulation |
| GRF6019 | Alzheimer's Disease (Phase 2) | Alkahest, Inc., Grifols Biologicals Inc. | Inflammation, Other, Unknown | Other | ||
| GSK239512 | Alzheimer's Disease (Discontinued) | GlaxoSmithKline (GSK) | Cholinergic System, Other Neurotransmitters | Small Molecule | ||
| GSK2647544 | GSK-2647544 | Alzheimer's Disease (Phase 1) | GlaxoSmithKline (GSK) | Cholesterol | Small Molecule | |
| GSK933776 | Alzheimer's Disease (Inactive) | GlaxoSmithKline (GSK) | Amyloid-Related | Immunotherapy (passive) | ||
| Galantamine | Razadyne™, Reminyl™, Nivalin® |
Alzheimer's Disease (Approved) | Janssen, Ortho-McNeil Pharmaceutical, Sanochemia Pharmazeutika, Shire, Takeda Pharmaceutical Company | Cholinergic System | Small Molecule | Mild to Moderate Alzheimer's disease |
| Gammagard® | Intravenous Immunoglobulin, IVIg |
Alzheimer's Disease (Discontinued) | Baxter Healthcare | Amyloid-Related, Inflammation | Immunotherapy (passive) | Immunodeficiency conditions |
| Gamunex | Intravenous Immunoglobulin, Human Albumin Combined With Flebogamma |
Alzheimer's Disease (Phase 2/3) | Grifols Biologicals Inc. | Amyloid-Related, Inflammation | Immunotherapy (passive) | Immunodeficiency, chronic inflammatory demyelinating neuropathy |
| Gantenerumab | RO4909832, RG1450 |
Alzheimer's Disease (Phase 3) | Chugai Pharmaceutical Co., Ltd., Hoffmann-La Roche | Amyloid-Related | Immunotherapy (passive) | |
| Gemfibrozil | Lopid, Jezil, Gen-Fibro |
Alzheimer's Disease (Phase 0) | Cholesterol | Small Molecule | Hyperlipidemia | |
| HF0220 | Alzheimer's Disease (Discontinued) | Newron | Inflammation | Small Molecule | ||
| HTL0018318 | Alzheimer's Disease (Phase 1), Dementia with Lewy Bodies (Phase 2) | Allergan plc, Sosei Heptares | Cholinergic System | Small Molecule | ||
| Huperzine A | ZT-1, DEBIO 9902 , Qian ceng ta, Cerebra capsule, Pharmassure Memorall capsule |
Alzheimer's Disease (Inactive) | Debiopharm Group™, Neuro-Hitech, Inc. | Cholinergic System | Small Molecule, Dietary Supplement | None |
| Ibuprofen | Advil™, Nuprin™ , Motrin™ |
Alzheimer's Disease (Discontinued) | Amyloid-Related, Inflammation | Small Molecule | Pain and Fever | |
| Idalopirdine | Lu AE58054, SGS 518 |
Alzheimer's Disease (Discontinued), Schizophrenia (Inactive) | H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Small Molecule | |
| Idebenone | Catena, Sovrima |
Alzheimer's Disease (Discontinued) | Takeda Pharmaceutical Company | Other | Small Molecule | None |
| Intepirdine | RVT-101, SB 742457 , GSK 742457 |
Alzheimer's Disease (Discontinued), Dementia with Lewy Bodies (Discontinued) | Axovant Sciences Ltd. | Other Neurotransmitters | Small Molecule | |
| JNJ-63733657 | Mild AD (Phase 1) | Janssen | Tau | Immunotherapy (passive) | ||
| Ketasyn | Axona, Caprylic Acid, AC-1202 |
Alzheimer's Disease (Phase 4) | Accera, Inc. | Other | Dietary Supplement | |
| LMTM | TRx0237, LMT-X, Methylene Blue, Tau aggregation inhibitor (TAI) |
Alzheimer's Disease (Phase 3), Frontotemporal Dementia (Phase 3) | TauRx Therapeutics Ltd | Tau | Small Molecule | Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia. |
| LU25-109 | Alzheimer's Disease (Discontinued) | Cholinergic System | Small Molecule | None | ||
| LY2599666 | Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | ||
| LY2886721 | BACE inhibitor | Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Small Molecule | |
| LY3202626 | BACE Inhibitor | Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Small Molecule | |
| LY3303560 | Alzheimer's Disease (Phase 2) | Eli Lilly & Co. | Tau, Unknown | Immunotherapy (passive) | ||
| LY3372993 | Alzheimer's Disease (Phase 1) | Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | ||
| Ladostigil | Ladostigil hemitartrate, TV3326 |
Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Discontinued) | Avraham Pharmaceuticals Ltd | Cholinergic System | Small Molecule | |
| Lanabecestat | AZD3293 , LY3314814, BACE inhibitor |
Alzheimer's Disease (Discontinued) | AstraZeneca, Eli Lilly & Co. | Amyloid-Related | Small Molecule | |
| Leuprolide | Leuprolide acetate | Alzheimer's Disease (Discontinued) | Other | Other | None | |
| Linopirdine | DuP996 | Alzheimer's Disease (Discontinued) | Other | Small Molecule | None | |
| Liraglutide | Victoza™ | Alzheimer's Disease (Phase 2) | Novo Nordisk A/S | Other | Small Molecule | |
| Lornoxicam | Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) | JSW Lifesciences | Inflammation | Small Molecule | Pain in US | |
| Lu AF20513 | Alzheimer's Disease (Phase 1) | H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. | Amyloid-Related | Immunotherapy (active) | ||
| Lumateperone | ITI-007 | Alzheimer's Disease (Phase 3), Schizophrenia (Phase 3), Bipolar Disorder (Phase 3) | Bristol-Myers Squibb, Intra-Cellular Therapies, Inc. | Other Neurotransmitters | Small Molecule | |
| MEDI1814 | Alzheimer's Disease (Phase 1) | Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | ||
| MEM 1003 | BAY Z 4406 | Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued), Vascular Dementia (Discontinued), Bipolar Disorder (Discontinued) | Memory Pharmaceuticals Corporation | Other | Small Molecule | None |
| MK-7622 | Alzheimer's Disease (Discontinued) | Merck | Unknown | Small Molecule | ||
| MKC-231 | Alzheimer's Disease (Inactive) | Mitsubishi Tanabe Pharma | Unknown | Small Molecule | None | |
| MSDC-0160 | Mitoglitazone | Alzheimer's Disease (Phase 2) | Metabolic Solutions Development Company | Other | Small Molecule | |
| Masitinib | Masivet, Kinavet, AB1010, Masitinib mesylate |
Alzheimer's Disease (Phase 3), Amyotrophic Lateral Sclerosis (Phase 3) | AB Science | Other | Small Molecule | |
| Melatonin | Alzheimer's Disease (Phase 2) | Other | Dietary Supplement | None | ||
| Memantine | Ebixa™, Namenda™ , Axura®, Akatinol®, Memary® |
Alzheimer's Disease (Approved) | Forest Laboratories, Inc., H. Lundbeck, Merz Pharma | Other Neurotransmitters | Small Molecule | Alzheimer's Disease |
| Metrifonate | trichlorfon | Alzheimer's Disease (Discontinued) | Cholinergic System | Small Molecule | None | |
| Milameline | CI 979 | Alzheimer's Disease (Discontinued) | Aventis Pharmaceuticals, Inc. (was Hoechst) | Cholinergic System | Small Molecule | None |
| Minocycline | Solodyn, Arestin, Minocin, Dynacin |
Alzheimer's Disease (Phase 2) | Inflammation | Small Molecule | ||
| NGX267 | AF267B | Alzheimer's Disease (Inactive) | TorreyPines Therapeutics, Inc. | Cholinergic System | Small Molecule | None |
| NIC5-15 | Pinitol, D-Pinitol |
Alzheimer's Disease (Phase 2) | Humanetics Pharmaceuticals Corporation | Amyloid-Related, Other | Small Molecule, Dietary Supplement | |
| NS2330 | Tesofensine | Alzheimer's Disease (Discontinued) | NeuroSearch A/S | Other Neurotransmitters | Small Molecule | |
| Naproxen | Aleve™, Anaprox™, Naprosyn™ |
Alzheimer's Disease (Discontinued) | Procter & Gamble | Inflammation | Small Molecule | Over-the-counter drug for reduction of pain, fever, inflammation, and stiffness. |
| Nasal Insulin | Detemir, Levemir, Humulin, Novolin |
Alzheimer's Disease (Phase 2/3), Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 2) | Amyloid-Related, Other | Small Molecule, Other | Diabetes | |
| Nefiracetam | Alzheimer's Disease (Discontinued) | Daiichi Sankyo Pharmaceuticals | Cholinergic System | Small Molecule | None | |
| Neflamapimod | VX-745 | Alzheimer's Disease (Phase 2) | EIP Pharma, LLC | Inflammation | Small Molecule | |
| Nelonicline | ABT-126 | Alzheimer's Disease (Discontinued), Schizophrenia (Inactive) | AbbVie | Cholinergic System | Small Molecule | |
| Nelotanserin | APD-125 | Dementia with Lewy Bodies (Discontinued) | Axovant Sciences Ltd. | Other Neurotransmitters | Small Molecule | |
| NeoTrofin | AIT-082, leteprinim |
Alzheimer's Disease (Discontinued) | NeoTherapeutics, Inc. | Unknown | Small Molecule | None |
| Neramexane | MRZ 2/579 | Alzheimer's Disease (Discontinued) | Forest Laboratories, Inc., Merck | Other Neurotransmitters | Small Molecule | None |
| Nicotinamide | Enduramide, Niacinamide, Nicotinic acid amide, Vitamin B3 |
Alzheimer's Disease (Phase 2) | Other | Small Molecule | ||
| Nilvadipine | Nilvad, Nivadil, ARC029 |
Alzheimer's Disease (Inactive) | Archer Pharmaceuticals, Inc. | Other | Small Molecule | |
| Nimodipine | Nimotop | Frontotemporal Dementia (Phase 1) | Bayer | Metals | Small Molecule | Subarachnoid hemorrhage |
| ORM-12741 | Alzheimer's Disease (Phase 2) | Orion Pharma | Other Neurotransmitters | Small Molecule | ||
| Octagam®10% | Intravenous Immunoglobulin, NewGam |
Alzheimer's Disease (Inactive), Mild Cognitive Impairment (Inactive) | Octapharma | Amyloid-Related, Inflammation | Immunotherapy (passive) | Immunodeficiency disorders |
| PBT2 | PBT-2 | Alzheimer's Disease (Phase 2), Huntington's Disease (Phase 2) | Prana Biotechnology Limited | Amyloid-Related, Metals | Small Molecule | |
| PF-05212377 | PF-5212377, WYE-103760, SAM-760 |
Alzheimer's Disease (Discontinued) | Pfizer | Other Neurotransmitters | Small Molecule | |
| PF-05251749 | Alzheimer's Disease (Discontinued) | Pfizer | Other | Small Molecule | ||
| PF-06648671 | Alzheimer's Disease (Discontinued) | Pfizer | Amyloid-Related | Small Molecule | ||
| PF-06751979 | BACE inhibitor | Alzheimer's Disease (Discontinued) | Pfizer | Amyloid-Related | Small Molecule | |
| PF-06852231 | Alzheimer's Disease (Discontinued) | Pfizer | Cholinergic System | Small Molecule | ||
| PQ912 | Alzheimer's Disease (Phase 2) | Probiodrug AG | Amyloid-Related, Inflammation | Small Molecule | ||
| PRX-03140 | Potassium salt | Alzheimer's Disease (Inactive) | Epix Pharmaceuticals | Other | Small Molecule | |
| PRX002 | RO7046015, RG7935, NEOD002 | Parkinson's Disease (Phase 2) | Hoffmann-La Roche, Prothena | alpha-synuclein | Immunotherapy (passive) | |
| PXT864 | PXT00864 | Alzheimer's Disease (Phase 2) | Pharnext | Other Neurotransmitters | Small Molecule | |
| Phenserine | Alzheimer's Disease (Inactive) | TorreyPines Therapeutics, Inc. | Cholinergic System | Small Molecule | ||
| Physostigmine Salicylate | Synapton | Alzheimer's Disease (Discontinued) | Forest Laboratories, Inc. | Cholinergic System | Small Molecule | |
| Pimavanserin | Nuplazid, ACP-103, Pimavanserin tartrate |
Alzheimer's Disease (Phase 2), Schizophrenia (Phase 3) | Acadia Pharmaceuticals | Other Neurotransmitters | Small Molecule | Parkinson's psychosis |
| Pioglitazone | AD4833, Actos®, Glustin™, Piozone® |
Mild Cognitive Impairment (Phase 3) | Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. | Inflammation, Other | Small Molecule | Type 2 diabetes mellitus |
| Piromelatine | Neu-P11 | Alzheimer's Disease (Phase 2) | Neurim Pharmaceuticals Ltd. | Other Neurotransmitters, Other | Small Molecule | |
| Ponezumab | PF-04360365 | Alzheimer's Disease (Discontinued), Cerebral Amyloid Angiopathy (Discontinued) | Pfizer | Amyloid-Related | Immunotherapy (passive) | None |
| Prazosin | Prazosin hydrochloride, Minipress, Hypovase, Vasoflex |
Alzheimer's Disease (Phase 4) | Other Neurotransmitters | Small Molecule | Hypertension | |
| Prednisone | Alzheimer's Disease (Discontinued) | Inflammation | Small Molecule | |||
| Propentofylline | HWA 285, PPF |
Alzheimer's Disease (Discontinued) | Unknown | Small Molecule | ||
| RG3487 | RO5313534, MEM 3454 |
Alzheimer's Disease (Inactive) | Roche | Cholinergic System | Small Molecule | |
| RG7129 | RO5508887, BACE Inhibitor |
Alzheimer's Disease (Discontinued) | Roche | Amyloid-Related | Small Molecule | |
| RG7345 | RO6926496 | Alzheimer's Disease (Discontinued) | Tau | Immunotherapy (passive) | ||
| Rember TM | Methylene Blue , methylthioninium (MT), TRx-0014, Tau aggregation inhibitor (TAI) |
Alzheimer's Disease (Discontinued) | TauRx Therapeutics Ltd | Tau | Small Molecule | Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia. |
| Repetitive Transcranial Magnetic Stimulation | rTMS | Alzheimer's Disease (Phase 2) | Neuronix Ltd | Other | Procedural Intervention | |
| Resveratrol | trans-3,4',5-trihydroxystilbene | Alzheimer's Disease (Phase 3), Mild Cognitive Impairment (Phase 4) | Other | Small Molecule, Dietary Supplement | ||
| Rilapladib | SB-659032 | Alzheimer's Disease (Phase 2) | GlaxoSmithKline (GSK) | Other | Small Molecule | |
| Riluzole | Rilutek®, RP 54274 |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) | Sanofi | Other Neurotransmitters, Other | Small Molecule | Amyotrophic Lateral Sclerosis in many countries |
| Rivastigmine | Exelon™, Rivastigmine tartrate , Rivastach® Patch, Prometax®, SDZ ENA 713 |
Alzheimer's Disease (Approved), Parkinson's Disease Dementia (Approved) | Novartis Pharmaceuticals Corporation | Cholinergic System | Small Molecule | Mild to moderate Alzheimer’s disease and mild to moderate dementia related to Parkinson's disease |
| Rofecoxib | Vioxx™ | Alzheimer's Disease (Discontinued) | Merck | Inflammation | Small Molecule | Withdrawn from market |
| Rosiglitazone | Rosiglitazone maleate, Avandia |
Alzheimer's Disease (Discontinued) | GlaxoSmithKline (GSK) | Other | Small Molecule | |
| S 38093 | Alzheimer's Disease (Discontinued) | Servier | Cholinergic System, Other Neurotransmitters | Small Molecule | ||
| S-Equol | Aus-131 | Alzheimer's Disease (Phase 1) | Ausio Pharmaceuticals, LLC | Other | Small Molecule | |
| S47445 | CX1632 | Alzheimer's Disease (Discontinued) | Cortex Pharmaceuticals, Inc., Servier | Other Neurotransmitters | Small Molecule | |
| SAR110894D | Alzheimer's Disease (Phase 2) | Sanofi | Other | Small Molecule | ||
| SAR228810 | Alzheimer's Disease (Phase 1) | Sanofi | Amyloid-Related | Immunotherapy (passive) | ||
| SB 202026 | Memric | Alzheimer's Disease (Discontinued) | Other Neurotransmitters | Small Molecule | ||
| SGS-742 | CGP-36742, DVD-742 |
Alzheimer's Disease (Discontinued) | Novartis Pharmaceuticals Corporation, Saegis Pharmaceuticals, Inc. | Other Neurotransmitters | Small Molecule | |
| ST101 | ZSET1446 | Alzheimer's Disease (Inactive) | Sonexa Therapeutics, Inc. | Unknown | Small Molecule | |
| SUVN-502 | Alzheimer's Disease (Phase 2) | Suven Life Sciences Ltd | Other Neurotransmitters | Small Molecule | ||
| SUVN-G3031 | Alzheimer's Disease (Phase 1) | Suven Life Sciences Ltd | Cholinergic System, Other Neurotransmitters | Small Molecule | ||
| Sabeluzole | R58735 | Alzheimer's Disease (Inactive) | Unknown | Small Molecule | ||
| Saracatinib | AZD0530 | Alzheimer's Disease (Phase 2) | AstraZeneca | Other | Small Molecule | |
| Semagacestat | LY450139 Dihydrate , hydroxylvaleryl monobenzocaprolactam |
Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Small Molecule | None |
| Sembragiline | RO4602522, RG1577 |
Alzheimer's Disease (Discontinued) | Evotech AG | Other Neurotransmitters, Other | Small Molecule | |
| Simvastatin | Zocor®, Lipex®, Lipovas®, Denan® |
Alzheimer's Disease (Inactive), Mild Cognitive Impairment (Phase 4) | Merck | Cholesterol | Small Molecule | Hypercholesterolemia and diabetic cardiomyopathy. |
| Solanezumab | LY2062430 | Alzheimer's Disease (Phase 3) | Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | None |
| Souvenaid | FortasynTM Connect | Alzheimer's Disease (Not Regulated) | Other | Dietary Supplement | ||
| Suritozole | MD 26479 | Alzheimer's Disease (Discontinued) | Aventis Pharmaceuticals, Inc. (was Hoechst) | Other Neurotransmitters | Small Molecule | |
| T3D-959 | DB959 | Alzheimer's Disease (Phase 2) | T3D Therapeutics, Inc. | Other | Small Molecule | |
| TPI 287 | Alzheimer's Disease (Phase 1), CBD (Phase 1), Progressive Supranuclear Palsy (Phase 1) | Cortice Biosciences | Tau | Small Molecule | ||
| Tacrine | Cognex™ | Alzheimer's Disease (Approved) | Pfizer, Shionogi Pharma | Cholinergic System | Small Molecule | |
| Telmisartan | Micardis | Alzheimer's Disease (Phase 2) | Boehringer Ingelheim | Other | Small Molecule | Hypertension |
| Thalidomide | Thalomid® | Alzheimer's Disease (Phase 2/3) | Celgene Corporation | Amyloid-Related, Inflammation | Small Molecule | |
| Tideglusib | NP031112, Nypta® , Zentylor™ , Glycogen synthase kinase 3 inhibitor, NP12 |
Alzheimer's Disease (Discontinued), Progressive Supranuclear Palsy (Discontinued) | Zeltia Group | Tau | Small Molecule | |
| Tricaprilin | AC-1204 , Caprylic triglyceride |
Alzheimer's Disease (Phase 2/3) | Accera, Inc. | Other | Dietary Supplement, Other | None |
| UB 311 | Alzheimer's Disease (Phase 2) | United Neuroscience | Amyloid-Related | Immunotherapy (active) | ||
| UCB0107 | UCB 0107 | Progressive Supranuclear Palsy (Phase 1) | UCB S.A. | Tau | Immunotherapy (passive) | |
| Umibecestat | CNP520, BACE Inhibitor |
Alzheimer's Disease (Phase 2/3) | Amgen, Inc., Novartis Pharmaceuticals Corporation | Amyloid-Related | Small Molecule | |
| VY-AADC | Parkinson's Disease (Phase 1) | Voyager Therapeutics | Other Neurotransmitters | DNA-based | ||
| Valproate | Depakote, Depakene, Valproic acid , Divalproex sodium |
Alzheimer's Disease (Inactive) | Abbott Laboratories | Other Neurotransmitters | Small Molecule | Epilepsy, Bipolar disorder, Migraine |
| Vanutide cridificar | ACC-001, PF-05236806 |
Alzheimer's Disease (Discontinued) | Janssen | Amyloid-Related | Immunotherapy (active) | None |
| Varenicline | Champix™, Chantix™, Varenicline tartrate, CP-526,555, Alpha4 beta2 nicotinic receptor agonist |
Alzheimer's Disease (Discontinued) | Pfizer | Cholinergic System | Small Molecule | Smoking cessation |
| Verubecestat | MK-8931, MK-8931-009 , BACE inhibitor |
Alzheimer's Disease (Discontinued) | Merck | Amyloid-Related | Small Molecule | |
| Xaliproden | SR 57746A | Alzheimer's Disease (Discontinued) | Sanofi | Other Neurotransmitters, Other | Small Molecule | |
| XanamemTM | UE 2343 | Alzheimer's Disease (Phase 2) | Actinogen Medical | Other | Small Molecule | |
| Young Plasma | Progressive Supranuclear Palsy (Phase 1), Alzheimer's Disease (Phase 1) | Alkahest, Inc., Grifols Biologicals Inc. | Inflammation, Other, Unknown | Other |