Therapeutics
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Name | Synonyms | FDA Status | Company | Target Type | Therapy Type | Approved For |
---|---|---|---|---|---|---|
AAB-003 | PF-05236812 | Alzheimer's Disease (Discontinued) | Janssen, Pfizer | Amyloid-Related | Immunotherapy (passive) | |
AADvac1 | Axon peptide 108 conjugated to KLH | Alzheimer's Disease (Phase 2), Progressive Nonfluent Aphasia (Phase 1) | Axon Neuroscience SE | Tau | Immunotherapy (active) | |
AAV-GAD | AAV-GAD2, NLX-P101 |
Parkinson's Disease (Phase 1/2) | MeiraGTx Limited | Other Neurotransmitters | DNA/RNA-based | |
AAV2-BDNF | MCI due to AD (Phase 1), Alzheimer's Disease (Phase 1) | Other | DNA/RNA-based | |||
ABBV-0805 | BAN0805 | Parkinson's Disease (Inactive) | AbbVie, BioArctic AB | alpha-synuclein | Immunotherapy (passive) | |
ABBV-552 | Alzheimer's Disease (Phase 1) | AbbVie | Other | Small Molecule | ||
ABBV-916 | N3pG-Abeta mAb | Alzheimer's Disease (Phase 2) | Amyloid-Related | Immunotherapy (passive) | ||
ABBV-CLS-7262 | Fosigotifator, Fosigotifator sodium tromethamine |
Amyotrophic Lateral Sclerosis (Phase 2) | AbbVie, Calico Life Sciences LLC. | Other | Small Molecule | |
ABT-089 | Alzheimer's Disease (Discontinued) | Abbott Laboratories | Cholinergic System | Small Molecule | ||
ABT-288 | Alzheimer's Disease (Discontinued) | AbbVie | Cholinergic System, Other Neurotransmitters | Small Molecule | ||
ABT-384 | Alzheimer's Disease (Discontinued) | AbbVie | Other | Small Molecule | ||
ABT-957 | Alicapistat | Alzheimer's Disease (Discontinued) | AbbVie | Other | Small Molecule | |
ABT 418 | Alzheimer's Disease (Discontinued) | Cholinergic System | Small Molecule | None | ||
ABvac40 | Alzheimer's Disease (Phase 2) | Araclon Biotech | Amyloid-Related | Immunotherapy (active) | ||
ACD856 | Alzheimer's Disease (Phase 1) | AlzeCure Pharma AB | Other | Small Molecule | ||
Acetyl-l-carnitine HCI | ALCAR | Alzheimer's Disease (Discontinued) | Sigma-Tau Pharmaceuticals | Other | Supplement, Dietary | |
ACI-24.060 | ACI-24, Pal1-15 acetate salt |
Alzheimer's Disease (Phase 2), Down's Syndrome (Phase 2) | AC Immune SA, Takeda Pharmaceutical Company | Amyloid-Related | Immunotherapy (active) | |
ACI-35 | VAC20121, JNJ-64042056 |
Alzheimer's Disease (Phase 2/3) | AC Immune SA, Janssen | Tau | Immunotherapy (active) | |
ACI-3024 | Tau MorphomerTM | Alzheimer's Disease (Inactive), Other Tauopathy (Phase 0) | AC Immune SA | Tau | Small Molecule | |
ACI-7104.056 | ACI-7104, Affitope PD01A, PD03A |
Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 1) | AC Immune SA, AFFiRiS AG | alpha-synuclein | Immunotherapy (active) | |
Acitretin | Soriatane , Neotigason, RO 101670 |
Alzheimer's Disease (Phase 2) | Actavis, Allergan plc | Amyloid-Related | Small Molecule | Psoriasis in US |
ACP-204 | Alzheimer's Disease (Phase 2/3) | Acadia Pharmaceuticals | Other Neurotransmitters | Small Molecule | ||
ADEL-Y01 | Alzheimer's Disease (Phase 1) | ADEL, Inc., Oscotec Inc. | Tau | Immunotherapy (passive) | ||
Aduhelm | Aducanumab, BIIB037 |
Alzheimer's Disease (Approved) | Biogen, Neurimmune | Amyloid-Related | Immunotherapy (passive) | |
AF 102B | cevimeline HCL, Evoxac™ |
Alzheimer's Disease (Discontinued) | SnowBrand Pharmaceuticals, Inc. | Cholinergic System | Small Molecule | Treatment of dry mouth in Sjogren's syndrome. |
Affitope AD02 | Alzheimer's Disease (Discontinued) | AFFiRiS AG | Amyloid-Related | Immunotherapy (active) | ||
AGB101 | levetiracetam | MCI-AD (Phase 2/3) | AgeneBio, Inc. | Amyloid-Related | Small Molecule | |
AKST4290 | ALK4290, lazucirnon |
Parkinson's Disease (Phase 2) | Alkahest, Inc. | Inflammation | Small Molecule | |
AL002 | Alzheimer's Disease (Phase 2) | AbbVie, Alector | Inflammation | Immunotherapy (passive) | ||
AL003 | Alzheimer's Disease (Discontinued) | AbbVie, Alector | Inflammation | Immunotherapy (passive) | ||
AL044 | Alzheimer's Disease (Phase 1) | Alector | Inflammation | Immunotherapy (passive) | ||
AL101 | GSK-4527226 | Alzheimer's Disease (Phase 2) | Alector, GlaxoSmithKline (GSK) | Other | Immunotherapy (passive) | |
Allopregnanolone | brexanolone, 3α-hydroxy-5α-pregnan-20-one, 3α,5α-tetrahydroprogesterone |
Alzheimer's Disease (Phase 2) | Other Neurotransmitters, Other | Small Molecule | ||
ALN-APP | Alzheimer's Disease (Phase 1) | Alnylam Pharmaceuticals, Inc., Regeneron Pharmaceuticals Inc. | Amyloid-Related | DNA/RNA-based | ||
ALPHA-1062 | GLN-1062 , Memogain |
Alzheimer's Disease (Phase 3) | Alpha Cognition, Galantos Pharma | Cholinergic System | Small Molecule | |
Alpha-Tocopherol | Vitamin E | Alzheimer's Disease (Phase 3) | Other | Supplement, Dietary | ||
ALX-001 | BMS-984923 | Alzheimer's Disease (Phase 1) | Allyx Therapeutics, Inc. | Amyloid-Related, Other Neurotransmitters | Small Molecule | |
ALZ-101 | Alzheimer's Disease (Phase 1) | Alzinova AB | Amyloid-Related | Immunotherapy (active) | ||
ALZ-801 | valiltramiprosate, NRM-8499, homotaurine prodrug, 3-APS |
Alzheimer's Disease (Phase 3) | Alzheon Inc. | Amyloid-Related | Small Molecule | |
Alzhemed™ | Vivimind™, Tramiprosate, NC-531, homotaurine, 3-APS |
Alzheimer's Disease (Discontinued) | Neurochem, Inc. | Amyloid-Related | Supplement, Dietary | None |
ALZT-OP1 | Cromolyn sodium, Intal, Ibuprofen |
Alzheimer's Disease (Phase 3) | AZTherapies, Inc. | Amyloid-Related, Inflammation | Combination, Small Molecule | |
Ambroxol | Ambrosan, Mucosolvan | Parkinson's Disease (Phase 2), Parkinson's Disease Dementia (Phase 2), Dementia with Lewy Bodies (Phase 2) | alpha-synuclein, Other | Small Molecule | ||
Amilomotide | CAD106 | Alzheimer's Disease (Inactive) | Novartis Pharmaceuticals Corporation | Amyloid-Related | Immunotherapy (active) | None |
AN-1792 | AIP 001 | Alzheimer's Disease (Discontinued) | Janssen, Pfizer | Amyloid-Related | Immunotherapy (active) | None |
ANX005 | Amyotrophic Lateral Sclerosis (Phase 2) | Annexon, Inc. | Inflammation, Other | Immunotherapy (passive) | ||
Apabetalone | RVX208, RVX000222 |
MCI-VaD (Phase 3) | Resverlogix Corporation | Other | Small Molecule | |
APNmAb005 | RAA7 | Alzheimer's Disease (Phase 1) | Aprinoia Therapeutics | Tau | Immunotherapy (passive) | |
AQW051 | Alpha-7 nicotinic acetylcholine receptor agonist | Alzheimer's Disease (Inactive), Parkinson's Disease (Phase 2), Schizophrenia (Phase 2) | Novartis Pharmaceuticals Corporation | Cholinergic System | Small Molecule | |
AR1001 | Alzheimer's Disease (Phase 3) | Aribio Co., Ltd. | Other | Small Molecule | ||
Aripiprazole | Abilify, BMS-337039 |
Alzheimer's Disease (Phase 3), Schizophrenia (Approved) | Bristol-Myers Squibb, Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Small Molecule | |
ASN51 | ASN121151 | Alzheimer's Disease (Phase 1) | Asceneuron SA | Tau | Small Molecule | |
ASN90 | ASN120290, ASN-561 |
Progressive Supranuclear Palsy (Phase 1) | Asceneuron SA | Tau | Small Molecule | |
Atabecestat | JNJ-54861911 , BACE inhibitor |
Alzheimer's Disease (Discontinued) | Janssen, Shionogi Pharma | Amyloid-Related | Small Molecule | |
Atomoxetine | ATX, Strattera |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 1) | Eli Lilly & Co. | Other Neurotransmitters | Small Molecule | ADHD in US |
Atorvastatin | Lipitor™ , Zarator®, Sortis®, Tahor® |
Alzheimer's Disease (Inactive) | Pfizer | Cholesterol | Small Molecule | Hypercholesterolaemia |
Atuzaginstat | COR388 | Alzheimer's Disease (Discontinued) | Cortexyme, Inc., Quince Therapeutics | Other | Small Molecule | |
AV-1959D | AV-1959 | Alzheimer's Disease (Phase 1) | Amyloid-Related | Immunotherapy (active) | ||
Avagacestat | BMS-708163 | Alzheimer's Disease (Discontinued) | Bristol-Myers Squibb | Amyloid-Related | Small Molecule | |
AVB-101 | Frontotemporal Dementia (Phase 1/2) | AviadoBio | Other | DNA/RNA-based | ||
AVP-786 | Alzheimer's Disease (Discontinued), Schizophrenia (Discontinued) | Avanir Pharmaceuticals, Concert Pharmaceuticals, Inc., Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Combination, Small Molecule | ||
AVP-923 | Nuedexta, Zenvia |
Alzheimer's Disease (Phase 4), Amyotrophic Lateral Sclerosis (Phase 3), Parkinson's Disease (Phase 3) | Avanir Pharmaceuticals, Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Combination, Small Molecule | |
AXS-05 | Dextromethorphan/bupropion, Auvelity |
Alzheimer's Disease (Phase 2/3) | Axsome Therapeutics, Inc. | Other Neurotransmitters | Combination, Small Molecule | Major depressive disorder |
AZD1446 | TC-6683 | Alzheimer's Disease (Discontinued) | AstraZeneca, Targacept | Cholinergic System | Small Molecule | None |
AZD3480 | ispronicline, TC-1734 |
Alzheimer's Disease (Inactive) | AstraZeneca, Targacept | Cholinergic System | Small Molecule | |
Azeliragon | PF-04494700, TTP488 |
Alzheimer's Disease (Discontinued) | Pfizer, TransTech Pharma, Inc., vTv Therapeutics LLC | Amyloid-Related, Inflammation | Small Molecule | |
Bapineuzumab | AAB-001 | Alzheimer's Disease (Discontinued) | Janssen, Pfizer | Amyloid-Related | Immunotherapy (passive) | |
Baricitinib | Olumiant®, NCB28050, LY3009104 |
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 1) | Eli Lilly & Co. | Inflammation | Small Molecule | Rheumatoid arthritis, Eczema (Europe, Japan only) |
Bemdaneprocel | BRT-DA01, MSK-DA01 |
Parkinson's Disease (Phase 1) | Bayer, BlueRock Therapeutics | Other Neurotransmitters, Other | Other | |
Benfotiamine | S-benzoylthiamine-O-monophosphate, Vitamin B1, Thiamine |
Alzheimer's Disease (Phase 2) | Inflammation, Other | Supplement, Dietary | ||
Bepranemab | UCB0107 , UCB 0107 , Antibody D |
Progressive Supranuclear Palsy (Phase 1), Alzheimer's Disease (Phase 2) | Hoffmann-La Roche, UCB S.A. | Tau | Immunotherapy (passive) | |
Besipirdine HCl | HP 749 | Alzheimer's Disease (Discontinued) | Aventis Pharmaceuticals, Inc. (was Hoechst) | Other Neurotransmitters | Small Molecule | |
Bexarotene | Targretin® | Alzheimer's Disease (Phase 2) | Ligand Pharmaceuticals, Inc., ReXceptor Inc. | Amyloid-Related, Unknown | Small Molecule | Cutaneous T-cell Lymphoma in US |
BI 409306 | SUB 166499 | Alzheimer's Disease (Discontinued), Schizophrenia (Phase 2) | Boehringer Ingelheim | Other Neurotransmitters, Other | Small Molecule | |
BI 1181181 | VTP 37948, BACE inhibitor |
Alzheimer's Disease (Discontinued) | Boehringer Ingelheim, Vitae Pharmaceuticals | Amyloid-Related | Small Molecule | |
Bifidobacterium breve A1 | MCC1274, B. breve |
Mild Cognitive Impairment (Phase 2) | Morinaga Milk Industry Co., Ltd | Other | Supplement, Dietary | |
BIIB076 | NI-105, 6C5 huIgG1/l |
Alzheimer's Disease (Discontinued) | Biogen, Eisai Co., Ltd., Neurimmune | Tau | Immunotherapy (passive) | |
BIIB078 | BIIB-078, IONIS-C9Rx |
Amyotrophic Lateral Sclerosis (Discontinued) | Biogen, IONIS Pharmaceuticals | Other | DNA/RNA-based | |
BIIB080 | IONIS-MAPTRx, ISIS 814907 |
Alzheimer's Disease (Phase 1) | Biogen, IONIS Pharmaceuticals | Tau | DNA/RNA-based | |
BIIB094 | ION859, IONIS-BIIB7Rx |
Parkinson's Disease (Phase 1) | Biogen, IONIS Pharmaceuticals | Inflammation, Other | DNA/RNA-based | |
BIIB100 | KPT-350 | Amyotrophic Lateral Sclerosis (Discontinued) | Biogen | Inflammation, Other | Small Molecule | |
BIIB105 | ION541 | Amyotrophic Lateral Sclerosis (Discontinued) | Biogen, IONIS Pharmaceuticals | Other | DNA/RNA-based | |
BIIB113 | Alzheimer's Disease (Phase 1) | Biogen | Tau | Small Molecule | ||
BIIB118 | PF-05251749 | Alzheimer's Disease (Phase 1), Parkinson's Disease (Phase 1) | Biogen | Other | Small Molecule | |
Blarcamesine | Anavex 2-73 | Alzheimer's Disease (Phase 2/3), Parkinson's Disease Dementia (Phase 2), Parkinson's Disease (Phase 1) | Anavex Life Science Corp. | Other | Small Molecule | |
BMS-986446 | PRX005 | Alzheimer's Disease (Phase 2) | Bristol-Myers Squibb, Prothena | Tau | Immunotherapy (passive) | |
Bosutinib | BOSULIF®, PF-5208763, SKI-606 |
Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2) | Pfizer | Other | Small Molecule | Chronic myeloid leukemia |
BPN14770 | Alzheimer's Disease (Phase 2) | Shionogi Pharma, Tetra Therapeutics | Cholinergic System, Other | Small Molecule | ||
Brexpiprazole | Rexulti, OPC 34712 |
Alzheimer's Disease (Approved), Schizophrenia (Approved) | Lundbeck, Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Small Molecule | |
Bryostatin 1 | Alzheimer's Disease (Phase 2) | Synaptogenix, Inc. | Other | Other | ||
Buntanetap | Posiphen, ANVS-401, Posiphen tartrate |
Alzheimer's Disease (Phase 2/3), Parkinson's Disease (Phase 3) | Annovis Bio | Amyloid-Related, alpha-synuclein | Small Molecule | |
Candesartan | Atacand, Candesartan cilexetil |
Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Phase 2) | AstraZeneca, Takeda Pharmaceutical Company | Other | Small Molecule | Hypertension, congestive heart failure |
Cannabidiol | CBD, Epidiolex |
Alzheimer's Disease (Phase 2) | Other Neurotransmitters | Small Molecule | Seizures in Dravet syndrome, Lennox-Gastaut syndrome or tuberous sclerosis complex | |
Carvedilol | Coreg, Artist , Aucardic, Dilatrend, Kredex |
Alzheimer's Disease (Phase 4) | Procter & Gamble | Unknown | Small Molecule | Hypertension, heart failure, angina pectoris |
CDNF | cerebral dopamine neurotrophic factor | Parkinson's Disease (Phase 1/2) | Herantis Pharma Plc, Renishaw plc. | Other | Procedural Intervention, Other | |
Celecoxib | Celebrex | Alzheimer's Disease (Discontinued) | Pfizer | Inflammation | Small Molecule | Pain, Arthritis |
CERE-110 | Nerve Growth Factor gene therapy | Alzheimer's Disease (Discontinued) | Sangamo BioSciences, Inc. | Other | DNA/RNA-based | |
Cerebrolysin | Alzheimer's Disease (Phase 2) | Ebewe Pharmaceutical | Other | Other | ||
CHF 5074 | Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Inactive) | CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. | Amyloid-Related, Inflammation, Other | Small Molecule | ||
Cinpanemab | BIIB054, NI-202 |
Parkinson's Disease (Discontinued) | Biogen, Neurimmune | alpha-synuclein | Immunotherapy (passive) | |
Circadin | Alzheimer's Disease (Phase 2) | Neurim Pharmaceuticals Ltd. | Other | Small Molecule | Insomnia | |
Citalopram | escitalopram, Celexa, Lexapro , Cipralex |
Alzheimer's Disease (Phase 3), Preclinical Alzheimer's Disease (Inactive) | Other Neurotransmitters | Small Molecule | Depression, generalized anxiety disorder | |
Clioquinol | iodochlorhydroxyquin, PBT-1 |
Alzheimer's Disease (Discontinued) | Prana Biotechnology Limited | Amyloid-Related, Metals | Small Molecule | |
CNM-Au8 | Gold nanocrystals | Parkinson's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 2/3) | Clene Nanomedicine, Inc. | Metals, Other | Other | |
Cocoa Flavanols | Mild Cognitive Impairment (Not Regulated) | Inflammation, Other | Supplement, Dietary | |||
COGNIShunt™ | Alzheimer's Disease (Inactive) | Other | Procedural Intervention | None | ||
Continuous Positive Airway Pressure | CPAP | Alzheimer's Disease (Phase 3) | Unknown | Procedural Intervention | Sleep Apnea in US | |
CpG 1018® | CpG oligodeoxynucleotides, CpG ODN |
Alzheimer's Disease (Phase 1) | Dynavax Technologies | Amyloid-Related, Inflammation | Immunotherapy (active), DNA/RNA-based | |
Crenezumab | MABT5102A , RG7412 |
Alzheimer's Disease (Discontinued) | AC Immune SA, Genentech, Hoffmann-La Roche | Amyloid-Related | Immunotherapy (passive) | None |
CS6253 | Cogpep™, CS-6253 |
Alzheimer's Disease (Phase 1) | Artery Therapeutics, Inc. | Amyloid-Related, Cholesterol | Small Molecule | |
CST-103 | Clenbuterol | Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 2) | Other Neurotransmitters | Small Molecule | Asthma, in countries outside the U.S. | |
CST-2032 | Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2) | CuraSen Therapeutics, Inc. | Other Neurotransmitters | Small Molecule | ||
CT1812 | Elayta | Alzheimer's Disease (Phase 2) | Cognition Therapeutics Inc. | Amyloid-Related | Small Molecule | |
Curcumin | diferuloylmethane, Longvida™ |
Alzheimer's Disease (Phase 2) | Verdure Sciences | Other, Unknown | Supplement, Dietary | None |
CVN424 | Parkinson's Disease (Phase 2) | Cerevance | Other Neurotransmitters | Small Molecule | ||
CX516 | Ampalex | Alzheimer's Disease (Discontinued) | Cortex Pharmaceuticals, Inc. | Other Neurotransmitters | Small Molecule | None |
CY6463 | IW-6463 | Alzheimer's Disease (Phase 2) | Cyclerion | Inflammation | Small Molecule | |
Dapagliflozin | Farxiga, Forxiga, BMS 512148 |
Alzheimer's Disease (Phase 1/2) | AstraZeneca, Bristol-Myers Squibb | Other | Small Molecule | |
Dapsone | Avlosulfon, Diaminodiphenylsulfone, DDS |
Alzheimer's Disease (Inactive) | Immune Network Ltd. | Other | Small Molecule | Leprosy, malaria, some bacterial skin infections |
Dasatinib + Quercetin | Alzheimer's Disease (Phase 1/2) | Tau, Other | Combination, Small Molecule, Supplement, Dietary | |||
Davunetide | NAP, AL-108 |
Mild Cognitive Impairment (Discontinued), Progressive Supranuclear Palsy (Discontinued), Schizophrenia (Discontinued), Frontotemporal Dementia (Inactive) | Allon Therapeutics Inc., Paladin Labs Inc. | Tau | Other | |
Dayvigo | Lemborexant, E2006 |
Alzheimer's Disease (Phase 2) | Eisai Co., Ltd. | Other | Small Molecule | Insomnia |
Deep Brain Stimulation-fornix | DBS-f | Alzheimer's Disease (Phase 3) | Functional Neuromodulation Ltd | Unknown | Procedural Intervention | |
Deep Brain Stimulation-nucleus basalis of Meynert | DBS-nbM | Alzheimer's Disease (Phase 2) | Cholinergic System, Other | Procedural Intervention | ||
Deferiprone | Ferriprox | Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 2/3), Amyotrophic Lateral Sclerosis (Phase 2/3) | Apotex Inc., Chiesi Pharmaceuticals Inc. | Metals | Small Molecule | Iron overload due to thalassemia syndromes |
Dexpramipexole | R-pramipexole, RPPX, KNS-760704 , BIIB 050 |
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) | Biogen, Knopp Biosciences LLC, Virginia Commonwealth University | Other Neurotransmitters, Other | Small Molecule | |
Dimebon | Dimebolin, Latrepirdine, Pf-01913539 |
Alzheimer's Disease (Discontinued), Huntington's Disease (Discontinued) | Medivation, Inc. | Other Neurotransmitters, Unknown | Small Molecule | Anti-histamine use in Russia |
Dipraglurant | ADX48621 | Parkinson's Disease (Discontinued) | Addex Therapeutics | Other Neurotransmitters | Small Molecule | |
DNL151 | BIIB122 | Parkinson's Disease (Phase 2) | Biogen, Denali Therapeutics Inc. | Inflammation, Other | Small Molecule | |
DNL201 | Parkinson's Disease (Inactive) | Biogen, Denali Therapeutics Inc. | Inflammation, Other | Small Molecule | ||
DNL343 | Amyotrophic Lateral Sclerosis (Phase 2/3) | Denali Therapeutics Inc. | Other | Small Molecule | ||
DNL593 | PTV:PGRN, TAK-594 |
Frontotemporal Dementia (Phase 1/2) | Denali Therapeutics Inc., Takeda Pharmaceutical Company | Other | Other | |
DNL747 | SAR443060 | Alzheimer's Disease (Inactive), Amyotrophic Lateral Sclerosis (Inactive) | Denali Therapeutics Inc., Sanofi | Inflammation | Small Molecule | |
DNL788 | SAR443820 | Amyotrophic Lateral Sclerosis (Phase 2) | Denali Therapeutics Inc., Sanofi | Inflammation | Small Molecule | |
DNL919 | TAK-920, ATV:TREM2 |
Alzheimer's Disease (Discontinued) | Denali Therapeutics Inc., Takeda Pharmaceutical Company | Amyloid-Related, Inflammation | Immunotherapy (passive) | |
Docosahexaenoic acid (DHA) | Omega-3 fatty acid | Alzheimer's Disease (Phase 4) | Martek Biosciences Corporation, NeuroBioPharm, Inc. | Other | Supplement, Dietary | |
Donanemab | N3pG-Aβ Monoclonal Antibody, LY3002813, Kisunla |
Alzheimer's Disease (Approved) | Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | |
Donepezil | Aricept™, Donepezil hydrochloride, Eranz®, E 2020 |
Alzheimer's Disease (Approved), Dementia with Lewy Bodies (Inactive), Down's Syndrome (Inactive), Parkinson's Disease Dementia (Inactive) | Corium, Inc., Eisai Co., Ltd., Pfizer | Cholinergic System | Small Molecule | Alzheimer's Disease, Dementia with Lewy Bodies (Japan) |
Dronabinol | THC , Marinol, Syndros, delta-9-tetrahydrocannabinol, delta-9-THC |
Alzheimer's Disease (Phase 2) | AbbVie, Others | Other Neurotransmitters | Small Molecule | Anorexia and weight loss in people with AIDS; Second-line treatment of nausea and vomiting due to chemotherapy |
E2511 | Alzheimer's Disease (Phase 1) | Eisai Co., Ltd. | Cholinergic System | Small Molecule | ||
E2814 | Alzheimer's Disease (Phase 1/2) | Eisai Co., Ltd. | Tau | Immunotherapy (passive) | ||
Edaravone | MCI-186, Radicava®, Radicut®, MT-1186, FAB122 |
Amyotrophic Lateral Sclerosis (Phase 4) | Mitsubishi Tanabe Pharma | Other | Small Molecule | Amyotrophic Lateral Sclerosis |
Edicotinib | JNJ-40346527, JNJ-527, PRV-6527 |
Alzheimer's Disease (Phase 1) | Janssen | Inflammation | Small Molecule | |
Edonerpic | T-817 MA, T 817 | Alzheimer's Disease (Discontinued) | Toyama Chemical Co., Ltd. | Other, Unknown | Small Molecule | |
Efavirenz | Efavirenz | Alzheimer's Disease (Phase 1) | Amyloid-Related, Tau, Cholesterol | Small Molecule | HIV infection | |
EHT 0202 | Etazolate | Alzheimer's Disease (Phase 2) | ExonHit Therapeutics | Other | Small Molecule | None |
Elenbecestat | E2609, BACE inhibitor |
Alzheimer's Disease (Discontinued) | Biogen, Eisai Co., Ltd. | Amyloid-Related | Small Molecule | |
ELND005 | AZD-103, Scyllo-inositol, cyclohexane-1,2,3,4,5,6-hexol |
Alzheimer's Disease (Inactive) | Elan Corporation, Opko Health, Speranza Therapeutics, Transition Therapeutics, Inc. | Amyloid-Related | Small Molecule | None |
Empagliflozin | Jardiance, BI-10773 |
Alzheimer's Disease (Phase 1) | Boehringer Ingelheim, Eli Lilly & Co. | Other | Small Molecule | Type 2 Diabetes, Cardiovascular disease |
Emrusolmin | Anle138b, TEV-56286 |
Parkinson's Disease (Phase 1/2), Multiple System Atrophy (Phase 2) | MODAG GmbH, Teva | Tau, alpha-synuclein, Other | Small Molecule | |
Emtricitabine | Alzheimer's Disease (Phase 1) | Gilead Sciences, Inc. | Other | Small Molecule | ||
Encenicline | EVP-6124 , MT-4666, α7-nAChR agonist |
Alzheimer's Disease (Discontinued), Schizophrenia (Discontinued) | FORUM Pharmaceuticals Inc., Mitsubishi Tanabe Pharma | Cholinergic System | Small Molecule | None |
Engensis | VM202, pCK-HGF-X7, NL003, hepatocyte growth factor | Amyotrophic Lateral Sclerosis (Phase 2) | Helixmith | Other | DNA/RNA-based | |
Epigallocatechin Gallate (EGCG) | Sunphenon EGCg | Alzheimer's Disease (Phase 2/3), Down's Syndrome (Phase 2), Multiple System Atrophy (Phase 3) | Taiyo International | Amyloid-Related, Inflammation, Other | Supplement, Dietary | |
Epothilone D | BMS-241027 | Alzheimer's Disease (Discontinued) | Bristol-Myers Squibb | Tau | Small Molecule | |
Eptastigmine | MF 201 | Alzheimer's Disease (Discontinued) | Mediolanum | Cholinergic System | Small Molecule | None |
Estrogen | Premarin™ | Alzheimer's Disease (Discontinued) | Other | Other | Hormone Replacement Therapy | |
Etanercept | Enbrel™ | Alzheimer's Disease (Phase 2) | Amgen, Inc., Pfizer | Inflammation | Immunotherapy (passive) | Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondilysis |
EVP-0962 | EVP 0015962 | Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) | FORUM Pharmaceuticals Inc. | Amyloid-Related | Small Molecule | |
Exenatide | Exendin-4, Byetta, Bydureon |
Alzheimer's Disease (Inactive), Parkinson's Disease (Phase 3) | AstraZeneca, Eli Lilly & Co. | Other | Small Molecule | Diabetes mellitus in US |
Ezeprogind | AZP2006 , AZP-2006 |
Progressive Supranuclear Palsy (Phase 2) | AlzProtect | Tau, Inflammation, Other | Small Molecule | |
Flurizan™ | tarenflurbil , r-flurbiprofen, MPC-7869 |
Alzheimer's Disease (Discontinued) | Myriad Genetics & Laboratories | Amyloid-Related | Small Molecule | None |
Focused Ultrasound – Blood-Brain Barrier | FUS-BBB, MRgFUS, MRI-Guided Focused Ultrasound, FUS+MB |
Alzheimer's Disease (Phase 1), Amyotrophic Lateral Sclerosis (Phase 1), Mild Cognitive Impairment (Phase 1), Parkinson's Disease (Phase 1) | Amyloid-Related, Other | Procedural Intervention | ||
Fosgonimeton | ATH-1017, NDX-1017 |
Alzheimer's Disease (Phase 2/3), Dementia with Lewy Bodies (Phase 2), Parkinson's Disease Dementia (Phase 2) | Athira Pharma | Other | Small Molecule | |
FRM-0334 | EVP-0334 | Frontotemporal Dementia (Discontinued) | FORUM Pharmaceuticals Inc. | Other | Small Molecule | |
G-CSF | Filgrastim | Alzheimer's Disease (Phase 2) | Other | Small Molecule | Neutropenia in US | |
Galantamine | Razadyne™, Reminyl™, Nivalin® |
Alzheimer's Disease (Approved) | Janssen, Ortho-McNeil Pharmaceutical, Sanochemia Pharmazeutika, Shire, Takeda Pharmaceutical Company | Cholinergic System | Small Molecule | Mild to Moderate Alzheimer's disease |
Gammagard® | Intravenous Immunoglobulin, IVIg |
Alzheimer's Disease (Discontinued) | Baxter Healthcare | Amyloid-Related, Inflammation | Immunotherapy (passive) | Immunodeficiency conditions |
Gamunex | Intravenous Immunoglobulin, Human Albumin Combined With Flebogamma |
Alzheimer's Disease (Phase 2/3) | Grifols Biologicals Inc. | Amyloid-Related, Inflammation | Combination, Immunotherapy (passive) | Immunodeficiency, chronic inflammatory demyelinating neuropathy |
Gantenerumab | RO4909832, RG1450, R1450 |
Alzheimer's Disease (Discontinued) | Chugai Pharmaceutical Co., Ltd., Hoffmann-La Roche | Amyloid-Related | Immunotherapy (passive) | |
GC021109 | Alzheimer's Disease (Phase 1) | GliaCure | Inflammation | Small Molecule | ||
Gemfibrozil | Lopid, Jezil, Gen-Fibro |
Alzheimer's Disease (Phase 1) | Cholesterol | Small Molecule | Hyperlipidemia | |
Gosuranemab | BIIB092, BMS-986168, IPN007 |
Progressive Supranuclear Palsy (Discontinued), Alzheimer's Disease (Discontinued) | Biogen, Bristol-Myers Squibb | Tau | Immunotherapy (passive) | |
GRF6019 | Alzheimer's Disease (Phase 2) | Alkahest, Inc., Grifols Biologicals Inc. | Inflammation, Other, Unknown | Other | ||
GRF6021 | AKST/GRF6021 | Parkinson's Disease Dementia (Phase 2) | Alkahest, Inc., Grifols Biologicals Inc. | Inflammation, Other, Unknown | Other | |
GSK239512 | Alzheimer's Disease (Discontinued) | GlaxoSmithKline (GSK) | Cholinergic System, Other Neurotransmitters | Small Molecule | ||
GSK933776 | Alzheimer's Disease (Inactive) | GlaxoSmithKline (GSK) | Amyloid-Related | Immunotherapy (passive) | ||
GSK2647544 | GSK-2647544 | Alzheimer's Disease (Phase 1) | GlaxoSmithKline (GSK) | Cholesterol | Small Molecule | |
Guanfacine | Intuniv, SPD503, Afken, Estulic, Tenex |
Alzheimer's Disease (Phase 3) | Other Neurotransmitters | Small Molecule | Attention-deficit hyperactivity disorder, hypertension | |
GV-971 | sodium oligomannate, sodium oligo-mannurarate |
Alzheimer's Disease (Inactive) | Shanghai Green Valley Pharmaceuticals | Amyloid-Related, Inflammation | Small Molecule | |
GV1001 | RIAVAXTM, Tertomotide | Alzheimer's Disease (Phase 3) | GemVax & KAEL Bio | Other | Immunotherapy (active) | Pancreatic cancer (Korea) |
HF0220 | Alzheimer's Disease (Discontinued) | Newron | Inflammation | Small Molecule | ||
HMTM | LMTM, LMTX, LMT-X, TRx0237, Tau aggregation inhibitor (TAI), Methylene Blue |
Alzheimer's Disease (Phase 3), Frontotemporal Dementia (Phase 3) | TauRx Therapeutics Ltd | Tau | Small Molecule | Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia. |
HTL0018318 | Alzheimer's Disease (Inactive), Dementia with Lewy Bodies (Inactive) | Allergan plc, Sosei Heptares | Cholinergic System | Small Molecule | ||
Huperzine A | ZT-1, DEBIO 9902 , Qian ceng ta, Cerebra capsule, Pharmassure Memorall capsule |
Alzheimer's Disease (Inactive) | Debiopharm Group™, Neuro-Hitech, Inc. | Cholinergic System | Small Molecule, Supplement, Dietary | None |
IBC-Ab002 | Alzheimer's Disease (Phase 1) | ImmunoBrain Checkpoint | Amyloid-Related, Inflammation, Other | Immunotherapy (passive) | ||
Ibuprofen | Advil™, Nuprin™ , Motrin™ |
Alzheimer's Disease (Discontinued) | Amyloid-Related, Inflammation | Small Molecule | Pain and Fever | |
Iclepertin | BI 425809 | Alzheimer's Disease (Discontinued), Schizophrenia (Phase 3) | Boehringer Ingelheim | Other Neurotransmitters | Small Molecule | |
Idalopirdine | Lu AE58054, SGS 518 |
Alzheimer's Disease (Discontinued), Schizophrenia (Inactive) | Lundbeck, Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Small Molecule | |
Idebenone | Catena, Sovrima |
Alzheimer's Disease (Discontinued) | Takeda Pharmaceutical Company | Other | Small Molecule | None |
Intepirdine | RVT-101, SB 742457 , GSK 742457 |
Alzheimer's Disease (Discontinued), Dementia with Lewy Bodies (Discontinued) | Axovant Sciences Ltd. | Other Neurotransmitters | Small Molecule | |
Intranasal oxytocin | Syntocinon, Pitocin |
Frontotemporal Dementia (Phase 2) | Other | Other | ||
Inzomelid | Emlenoflast, IZD174, MCC-7840 |
Alzheimer's Disease (Discontinued), Parkinson's Disease (Discontinued) | Hoffmann-La Roche, Inflazome Ltd. | Inflammation | Small Molecule | |
ION464 | BIIB101, IONIS-BIIB6Rx |
Multiple System Atrophy (Phase 1) | Biogen, IONIS Pharmaceuticals | alpha-synuclein | DNA/RNA-based | |
Irsenontrine | E2027 | Dementia with Lewy Bodies (Phase 2) | Eisai Co., Ltd. | Other | Small Molecule | |
KarXT | xanomeline-trospium | Alzheimer's Disease (Phase 3) | Karuna Therapeutics | Cholinergic System | Combination, Small Molecule | |
Ketasyn | Axona, Caprylic Acid, AC-1202 |
Alzheimer's Disease (Phase 4) | Cerecin Pte. Ltd. | Other | Supplement, Dietary | |
kMCT-ONS | medium chain triglyceride-based ketogenic oral nutritional supplement, kMCT | Alzheimer's Disease (Not Regulated) | Nestlé Health Science | Other | Supplement, Dietary | |
Kynmobi | APL-130277, apomorphine hydrochloride sublingual thin film |
Parkinson's Disease (Approved) | Sunovion Pharmaceuticals Inc. | Other Neurotransmitters | Small Molecule | |
Ladostigil | Ladostigil hemitartrate, TV3326 |
Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Discontinued) | Avraham Pharmaceuticals Ltd | Cholinergic System | Small Molecule | |
Lanabecestat | AZD3293 , LY3314814, BACE inhibitor |
Alzheimer's Disease (Discontinued) | AstraZeneca, Eli Lilly & Co. | Amyloid-Related | Small Molecule | |
Latozinemab | AL001, GSK4527223 |
Frontotemporal Dementia (Phase 3), Amyotrophic Lateral Sclerosis (Inactive) | Alector, GlaxoSmithKline (GSK) | Other | Immunotherapy (passive) | |
Lenalidomide | Revlimid | Alzheimer's Disease (Phase 2) | Celgene Corporation | Amyloid-Related, Inflammation | Small Molecule | Multiple myeloma, lymphoma, myelodysplastic syndromes |
Leqembi | Lecanemab-irmb, BAN2401, mAb158 |
Alzheimer's Disease (Approved) | BioArctic AB, Biogen, Eisai Co., Ltd. | Amyloid-Related | Immunotherapy (passive) | |
Leuprolide | Leuprolide acetate , Lupron Depot, Eligard |
Alzheimer's Disease (Phase 2) | Tolmar Pharmaceuticals, Inc. | Other | Other | Advanced prostate cancer |
Levetiracetam | Keppra | Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued) | UCB S.A. | Amyloid-Related, Other | Small Molecule | Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries |
Levodopa | L-Dopa, Sinemet, Duodopa, Duopa, Inbrija, Parcopa, Prolopa, Rytary, Stalevo, Foslevodopa |
Parkinson's Disease (Approved) | AbbVie, Acorda Therapeutics, Inc., Amneal Pharmaceuticals, Inc. | Other Neurotransmitters | Small Molecule | |
Linopirdine | DuP996 | Alzheimer's Disease (Discontinued) | Other | Small Molecule | None | |
Liraglutide | Victoza™, Saxenda™ |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 2) | Novo Nordisk A/S | Other | Other | Diabetes, weight loss |
Lixisenatide | Adlyxin, Lyxumia |
Parkinson's Disease (Phase 2) | Sanofi | Other | Other | Type 2 diabetes |
LM11A-31-BHS | LM11A-31 | Alzheimer's Disease (Phase 2) | PharmatrophiX | Other | Small Molecule | |
Lomecel-B | mesenchymal stem cells | Alzheimer's Disease (Phase 2) | Longeveron | Inflammation, Other | Other | |
Lornoxicam | Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) | JSW Lifesciences | Inflammation | Small Molecule | Pain in US | |
Losartan | Cozaar®, MK0954 |
Alzheimer's Disease (Phase 2) | Merck | Other | Small Molecule | Hypertension, diabetic neuropathy |
Low Dose Interleukin-2 | COYA-301, Aldesleukin, Proleukin, COYA-302, ld IL-2 |
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 3) | Coya Therapeutics | Inflammation | Other | |
LTI-291 | Parkinson's Disease (Phase 2) | Lysosomal Therapeutics Inc. | Other | Small Molecule | ||
LU25-109 | Alzheimer's Disease (Discontinued) | Cholinergic System | Small Molecule | None | ||
Lu AF20513 | Alzheimer's Disease (Discontinued) | Lundbeck, Otsuka Pharmaceutical Co., Ltd. | Amyloid-Related | Immunotherapy (active) | ||
LU AF82422 | Parkinson's Disease (Phase 1), Multiple System Atrophy (Phase 2) | Genmab A/S, Lundbeck | alpha-synuclein | Immunotherapy (passive) | ||
Lu AF87908 | hC10.2 | Alzheimer's Disease (Phase 1) | Lundbeck | Tau | Immunotherapy (passive) | |
Lu AF88434 | Mild Cognitive Impairment (Discontinued) | Lundbeck | Other | Small Molecule | ||
Lumateperone | ITI-007 | Alzheimer's Disease (Phase 3), Schizophrenia (Phase 3), Bipolar Disorder (Phase 3) | Bristol-Myers Squibb, Intra-Cellular Therapies, Inc. | Other Neurotransmitters | Small Molecule | |
LX1001 | AAVrh.10-APOE2, AAVrh.10hAPOE2 |
Alzheimer's Disease (Phase 1) | Lexeo Therapeutics | Amyloid-Related | DNA/RNA-based | |
LY2599666 | Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | ||
LY2886721 | BACE inhibitor | Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Small Molecule | |
LY3202626 | BACE Inhibitor | Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Small Molecule | |
LY3372689 | Alzheimer's Disease (Phase 2) | Eli Lilly & Co. | Tau | Small Molecule | ||
LY3884961 | PR001, PR001A |
Parkinson's Disease (Phase 1/2) | Eli Lilly & Co., Prevail Therapeutics | Other | DNA/RNA-based | |
LY3884963 | PR006 | Frontotemporal Dementia (Phase 1/2) | Eli Lilly & Co., Prevail Therapeutics | Other | DNA/RNA-based | |
Masitinib | Masivet, Kinavet, AB1010, Masitinib mesylate |
Alzheimer's Disease (Phase 3), Amyotrophic Lateral Sclerosis (Phase 3) | AB Science | Other | Small Molecule | |
Masupirdine | SUVN-502 | Alzheimer's Disease (Phase 3) | Suven Life Sciences Ltd | Other Neurotransmitters | Small Molecule | |
MEDI1814 | Alzheimer's Disease (Phase 1) | AstraZeneca, Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | ||
Melatonin | Alzheimer's Disease (Phase 2) | Other | Supplement, Dietary | None | ||
MEM 1003 | BAY Z 4406 | Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued), Vascular Dementia (Discontinued), Bipolar Disorder (Discontinued) | Memory Pharmaceuticals Corporation | Other | Small Molecule | None |
Memantine | Ebixa™, Namenda™ , Axura®, Akatinol®, Memary® |
Alzheimer's Disease (Approved) | Forest Laboratories, Inc., Lundbeck, Merz Pharma | Other Neurotransmitters | Small Molecule | Alzheimer's Disease |
MemorEM Transcranial Electromagnetic Treatment | TEMT | Alzheimer's Disease (Phase 1) | NeuroEM Therapeutics, Inc. | Amyloid-Related, Other | Procedural Intervention | |
Metformin | Glucophage, Glucophage XR |
Alzheimer's Disease (Phase 2/3) | Other | Small Molecule | Type 2 Diabetes | |
Methylphenidate | Ritalin, Concerta | Alzheimer's Disease (Phase 4) | Other Neurotransmitters | Small Molecule | Attention-deficit hyperactivity disorder (ADHD), narcolepsy | |
Metrifonate | trichlorfon | Alzheimer's Disease (Discontinued) | Cholinergic System | Small Molecule | None | |
Mevidalen | LY3154207, Mevidalen hydroxybenzoate |
Parkinson's Disease Dementia (Phase 2), Dementia with Lewy Bodies (Phase 2) | Eli Lilly & Co. | Other Neurotransmitters | Small Molecule | |
Milameline | CI 979 | Alzheimer's Disease (Discontinued) | Aventis Pharmaceuticals, Inc. (was Hoechst) | Cholinergic System | Small Molecule | None |
Minocycline | Solodyn, Arestin, Minocin, Dynacin |
Alzheimer's Disease (Discontinued) | Other | Small Molecule | ||
Minzasolmin | UCB0599, NPT200-11 |
Parkinson's Disease (Phase 2) | Neuropore Therapies, Inc., Novartis Pharmaceuticals Corporation, UCB S.A. | alpha-synuclein | Small Molecule | |
Mirtazapine | Remeron, esmirtazapine, Org 50081 |
Alzheimer's Disease (Phase 3) | Other Neurotransmitters | Small Molecule | ||
MK-1942 | Alzheimer's Disease (Discontinued) | Merck | Unknown | Small Molecule | ||
MK-2214 | Alzheimer's Disease (Phase 1) | Merck | Tau | Immunotherapy (passive) | ||
MK-7622 | Alzheimer's Disease (Discontinued) | Merck | Unknown | Small Molecule | ||
MK-8189 | Alzheimer's Disease (Phase 1) | Merck | Other Neurotransmitters | Small Molecule | ||
MKC-231 | Alzheimer's Disease (Inactive) | Mitsubishi Tanabe Pharma | Unknown | Small Molecule | None | |
Montelukast | Singulair, MK0476 | Alzheimer's Disease (Phase 2) | Intelgenx | Inflammation | Small Molecule | Asthma |
MSDC-0160 | Mitoglitazone | Alzheimer's Disease (Phase 2) | Metabolic Solutions Development Company | Other | Small Molecule | |
Multivitamin-mineral Supplement | Centrum Silver | Mild Cognitive Impairment (Not Regulated) | Pfizer | Other | Supplement, Dietary | |
MW150 | MW01-18-150SRM | Alzheimer's Disease (Phase 2) | Neurokine Therapeutics | Inflammation, Other | Small Molecule | |
MW151 | MW01-2-151SRM, Minozac, MW01-2-151WH, compound 17 |
Alzheimer's Disease (Phase 1) | ImmunoChem Therapeutics, LLC | Inflammation | Small Molecule | |
NA-831 | Traneurocin | Alzheimer's Disease (Phase 2) | Biomed Industries, NeuroActiva™ Inc. | Cholinergic System | Small Molecule | |
Nabilone | Cesamet | Alzheimer's Disease (Phase 3), Parkinson's Disease (Phase 2) | Bausch Health Companies Inc. | Other Neurotransmitters | Small Molecule | Nausea associated with cancer chemotherapy (US and other countries); pain spasticity in multiple sclerosis (Canada and other countries). |
Naproxen | Aleve™, Anaprox™, Naprosyn™ |
Alzheimer's Disease (Discontinued) | Procter & Gamble | Inflammation | Small Molecule | Over-the-counter drug for reduction of pain, fever, inflammation, and stiffness. |
Nasal Insulin | Detemir, Levemir, Humulin, Novolin, glulisine |
Alzheimer's Disease (Phase 2/3), Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 2) | Amyloid-Related, Other | Small Molecule, Other | Diabetes | |
NE3107 | HE3286 | Alzheimer's Disease (Phase 3), Parkinson's Disease (Phase 1/2) | BioVie Pharma | Inflammation, Other | Small Molecule | |
Nefiracetam | Alzheimer's Disease (Discontinued) | Daiichi Sankyo Pharmaceuticals | Cholinergic System | Small Molecule | None | |
Neflamapimod | VX-745 | Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2), Huntington's Disease (Discontinued) | CervoMed, Inc. | Inflammation | Small Molecule | |
Nelonicline | ABT-126 | Alzheimer's Disease (Discontinued), Schizophrenia (Inactive) | AbbVie | Cholinergic System | Small Molecule | |
Nelotanserin | APD-125 | Dementia with Lewy Bodies (Discontinued) | Axovant Sciences Ltd. | Other Neurotransmitters | Small Molecule | |
NeoTrofin | AIT-082, leteprinim |
Alzheimer's Disease (Discontinued) | NeoTherapeutics, Inc. | Unknown | Small Molecule | None |
Neramexane | MRZ 2/579 | Alzheimer's Disease (Discontinued) | Forest Laboratories, Inc., Merck | Other Neurotransmitters | Small Molecule | None |
NeuroAD | Repetitive Transcranial Magnetic Stimulation , rTMS-Cog |
Alzheimer's Disease (Rejected) | Neuronix Ltd | Other | Procedural Intervention | |
NIC5-15 | Pinitol, D-Pinitol |
Alzheimer's Disease (Phase 2) | Humanetics Pharmaceuticals Corporation | Amyloid-Related, Other | Small Molecule, Supplement, Dietary | |
Nicotinamide Riboside | Niagen, NR, Nicotinamide, Vitamin B3 |
Alzheimer's Disease (Phase 1), Parkinson's Disease (Phase 2), Mild Cognitive Impairment (Phase 1/2) | ChromaDex, Others | Other | Supplement, Dietary | |
Nilotinib | Tasigna, AMN107 |
Parkinson's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2), Alzheimer's Disease (Phase 3) | KeifeRx | Other | Small Molecule | Chronic myeloid leukemia |
Nilvadipine | Nilvad, Nivadil, ARC029 |
Alzheimer's Disease (Inactive) | Archer Pharmaceuticals, Inc. | Other | Small Molecule | |
Nimodipine | Nimotop | Frontotemporal Dementia (Discontinued) | Bayer | Metals | Small Molecule | Subarachnoid hemorrhage |
NIO752 | Progressive Supranuclear Palsy (Phase 1), Alzheimer's Disease (Phase 1) | Novartis Pharmaceuticals Corporation | Tau | DNA/RNA-based | ||
NPT520-34 | Amyotrophic Lateral Sclerosis (Phase 1), Parkinson's Disease (Phase 1) | Neuropore Therapies, Inc. | alpha-synuclein, Inflammation, Other | Small Molecule | ||
NS2330 | Tesofensine | Alzheimer's Disease (Discontinued) | NeuroSearch A/S | Other Neurotransmitters | Small Molecule | |
NSC001 | AF267B , NGX267, NI004 |
Alzheimer's Disease (Phase 1/2) | Neurimmune, TorreyPines Therapeutics, Inc. | Cholinergic System | Small Molecule | None |
NT-0796 | Propan-2-yl (2R)-2-{[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)- carbamoyl]oxy}-3-(pyrimidin-2-yl)propanoate | Parkinson's Disease (Phase 1/2) | NodThera | Inflammation | Small Molecule | |
NTRX-07 | MDA7 | Alzheimer's Disease (Phase 1) | NeuroTherapia, Inc. | Inflammation, Other | Small Molecule | |
Nuplazid | Pimavanserin, ACP-103, Pimavanserin tartrate |
Alzheimer's Disease (Rejected), Schizophrenia (Discontinued), Dementia (Rejected), Depression (Discontinued) | Acadia Pharmaceuticals | Other Neurotransmitters | Small Molecule | Parkinson's psychosis |
NurOwn™ | MSC-NTF Cells, debamestrocel , Neurotrophic factors-secreting Mesenchymal Stromal Cells |
Amyotrophic Lateral Sclerosis (Phase 3) | BrainStorm Cell Therapeutics, Inc. | Other | Other | |
NX210c | HWSGWSS[CSRSC]GOH (brackets represent the disulfide bond) | Amyotrophic Lateral Sclerosis (Phase 2), Parkinson's Disease (Phase 1) | Axoltis Pharma | Other | Small Molecule | |
NYX-458 | PD-MCI (Discontinued) | Aptinyx Inc. | Other Neurotransmitters | Small Molecule | ||
Obicetrapib | TA-8995 | Alzheimer's Disease (Phase 2) | NewAmsterdam Pharma | Cholesterol | Small Molecule | |
Octagam®10% | Intravenous Immunoglobulin, NewGam |
Alzheimer's Disease (Inactive), Mild Cognitive Impairment (Inactive) | Octapharma | Amyloid-Related, Inflammation | Immunotherapy (passive) | Immunodeficiency disorders |
OLX-07010 | Alzheimer's Disease (Phase 1) | Oligomerix, Inc. | Tau | Small Molecule | ||
ORM-12741 | Alzheimer's Disease (Phase 2) | Orion Pharma | Other Neurotransmitters | Small Molecule | ||
PBFT02 | Frontotemporal Dementia (Phase 1/2) | Passage Bio | Other | DNA/RNA-based | ||
PBT2 | PBT-2 | Alzheimer's Disease (Inactive), Huntington's Disease (Inactive) | Alterity Therapeutics | Amyloid-Related, Metals | Small Molecule | |
Pepinemab | VX15, VX15/2503 |
Alzheimer's Disease (Phase 1/2), Huntington's Disease (Phase 2) | Vaccinex, Inc. | Inflammation | Immunotherapy (passive) | |
PF-05212377 | PF-5212377, WYE-103760, SAM-760 |
Alzheimer's Disease (Discontinued) | Pfizer | Other Neurotransmitters | Small Molecule | |
PF-06648671 | Alzheimer's Disease (Discontinued) | Pfizer | Amyloid-Related | Small Molecule | ||
PF-06751979 | BACE inhibitor | Alzheimer's Disease (Discontinued) | Pfizer | Amyloid-Related | Small Molecule | |
PF-06852231 | Alzheimer's Disease (Discontinued) | Pfizer | Cholinergic System | Small Molecule | ||
Phenserine | Alzheimer's Disease (Inactive) | Annovis Bio, TorreyPines Therapeutics, Inc. | Cholinergic System | Small Molecule | ||
PhotoBioModulation | Low level light therapy, Low level laser therapy, Cold laser therapy, Transcranial infrared brain stimulation, Transcranial photobiomodulation, Transcranial near-infrared laser therapy (NILT), Transcranial low-level light therapy |
Alzheimer's Disease (Not Regulated), Mild Cognitive Impairment (Not Regulated), Parkinson's Disease (Not Regulated) | Inflammation, Unknown | Procedural Intervention | ||
Physostigmine Salicylate | Synapton | Alzheimer's Disease (Discontinued) | Forest Laboratories, Inc. | Cholinergic System | Small Molecule | |
Pioglitazone | AD4833, Actos®, Glustin™, Piozone® |
Mild Cognitive Impairment (Phase 3) | Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. | Inflammation, Other | Small Molecule | Type 2 diabetes mellitus |
Piromelatine | Neu-P11 | Alzheimer's Disease (Phase 2) | Neurim Pharmaceuticals Ltd. | Other Neurotransmitters, Other | Small Molecule | |
PMN310 | Alzheimer's Disease (Phase 1) | ProMIS Neurosciences, Inc. | Amyloid-Related | Immunotherapy (passive) | ||
PNT001 | Alzheimer's Disease (Inactive), Traumatic Brain Injury (Inactive) | Pinteon Therapeutics | Tau | Immunotherapy (passive) | ||
Ponezumab | PF-04360365 | Alzheimer's Disease (Discontinued), Cerebral Amyloid Angiopathy (Discontinued) | Pfizer | Amyloid-Related | Immunotherapy (passive) | None |
Posdinemab | JNJ-63733657 | Mild AD (Phase 2) | Janssen | Tau | Immunotherapy (passive) | |
Prasinezumab | PRX002, RO7046015, RG7935, NEOD002 | Parkinson's Disease (Phase 2) | Hoffmann-La Roche, Prothena | alpha-synuclein | Immunotherapy (passive) | |
Prazosin | Prazosin hydrochloride, Minipress, Hypovase, Vasoflex |
Alzheimer's Disease (Phase 4) | Other Neurotransmitters | Small Molecule | Hypertension | |
Prednisone | Alzheimer's Disease (Discontinued) | Inflammation | Small Molecule | |||
PRI-002 | Contraloid, contraloid acetate, RD2 |
Alzheimer's Disease (Phase 1) | Priavoid GmbH | Amyloid-Related | Small Molecule | |
Pridopidine | ACR16, TV-7820, Huntexil, ASP2314 |
Amyotrophic Lateral Sclerosis (Phase 2/3), Huntington's Disease (Phase 3), Parkinson's Disease (Inactive) | Prilenia Therapeutics | Other | Small Molecule | |
Propentofylline | HWA 285, PPF |
Alzheimer's Disease (Discontinued) | Unknown | Small Molecule | ||
Protollin | Alzheimer's Disease (Phase 1) | I-MAB Biopharma Co., Ltd., Jiangsu Nhwa Pharmaceutical Co., Ltd | Inflammation | Immunotherapy (active) | ||
PRX-03140 | Potassium salt | Alzheimer's Disease (Inactive) | Epix Pharmaceuticals | Other | Small Molecule | |
PRX012 | Alzheimer's Disease (Phase 1) | Prothena | Amyloid-Related | Immunotherapy (passive) | ||
PU-AD | PU-HZ151, icapamespib |
Alzheimer's Disease (Phase 2) | Samus Therapeutics | Other | Small Molecule | |
PXT864 | PXT00864 | Alzheimer's Disease (Discontinued) | Pharnext | Other Neurotransmitters | Combination, Small Molecule | |
QALSODY™ | Tofersen, BIIB067, Ionis-SOD1Rx , ASO1 |
Amyotrophic Lateral Sclerosis (Approved) | Biogen, IONIS Pharmaceuticals | Other | DNA/RNA-based | ALS |
QRL-101 | QRA-244 | Amyotrophic Lateral Sclerosis (Phase 1) | QurAlis Corporation | Other | Small Molecule | |
QRL-201 | Amyotrophic Lateral Sclerosis (Phase 1) | QurAlis Corporation | Other | DNA/RNA-based | ||
Rasagiline | Rasagiline mesylate, Azilect, TVP-1012 |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Approved), Amyotrophic Lateral Sclerosis (Inactive) | Teva | Other Neurotransmitters | Small Molecule | |
Relyvrio | Albrioza, AMX0035 |
Amyotrophic Lateral Sclerosis (Approved), Alzheimer's Disease (Phase 2) | Amylyx Pharmaceuticals Inc | Other | Combination, Small Molecule | ALS |
Rember TM | Methylene Blue , methylthioninium (MT), TRx-0014, Tau aggregation inhibitor (TAI) |
Alzheimer's Disease (Discontinued) | TauRx Therapeutics Ltd | Tau | Small Molecule | Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia. |
Remternetug | LY3372993, N3pG-Abeta mAb |
Alzheimer's Disease (Phase 3) | Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | |
Resveratrol | trans-3,4',5-trihydroxystilbene | Alzheimer's Disease (Phase 3), Mild Cognitive Impairment (Phase 4) | Other | Small Molecule, Supplement, Dietary | ||
RG3487 | RO5313534, MEM 3454 |
Alzheimer's Disease (Inactive) | Cholinergic System | Small Molecule | ||
RG6289 | Alzheimer's Disease (Phase 1/2) | Hoffmann-La Roche | Amyloid-Related | Small Molecule | ||
RG7129 | RO5508887, BACE Inhibitor |
Alzheimer's Disease (Discontinued) | Roche | Amyloid-Related | Small Molecule | |
RG7345 | RO6926496 | Alzheimer's Disease (Discontinued) | Tau | Immunotherapy (passive) | ||
Rilapladib | SB-659032 | Alzheimer's Disease (Discontinued) | GlaxoSmithKline (GSK) | Other | Small Molecule | |
Riluzole | Rilutek®, RP 54274 |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) | Sanofi | Other Neurotransmitters, Other | Small Molecule | Amyotrophic Lateral Sclerosis in many countries |
Rivastigmine | Exelon™, Rivastigmine tartrate , Rivastach® Patch, Prometax®, SDZ ENA 713 |
Alzheimer's Disease (Approved), Parkinson's Disease Dementia (Approved) | Novartis Pharmaceuticals Corporation | Cholinergic System | Small Molecule | Mild to moderate Alzheimer’s disease and mild to moderate dementia related to Parkinson's disease |
Rofecoxib | Vioxx™ | Alzheimer's Disease (Discontinued) | Merck | Inflammation | Small Molecule | Withdrawn from market |
Rosiglitazone | Rosiglitazone maleate, Avandia |
Alzheimer's Disease (Discontinued) | GlaxoSmithKline (GSK) | Other | Small Molecule | |
Rotigotine | Neupro | Alzheimer's Disease (Phase 2), Frontotemporal Dementia (Phase 2) | UCB S.A. | Other Neurotransmitters | Small Molecule | Parkinson's disease, Restless Leg Syndrome |
S-Equol | Aus-131 | Alzheimer's Disease (Phase 1) | Ausio Pharmaceuticals, LLC | Other | Small Molecule | |
S 38093 | Alzheimer's Disease (Discontinued) | Servier | Cholinergic System, Other Neurotransmitters | Small Molecule | ||
S47445 | CX1632 | Alzheimer's Disease (Discontinued) | Cortex Pharmaceuticals, Inc., Servier | Other Neurotransmitters | Small Molecule | |
Sabeluzole | R58735 | Alzheimer's Disease (Inactive) | Unknown | Small Molecule | ||
Sabirnetug | ACU-193 | Alzheimer's Disease (Phase 2/3) | Acumen Pharmaceuticals, Inc. | Amyloid-Related | Immunotherapy (passive) | |
Safinamide | Xadago, Onstryv |
Multiple System Atrophy (Phase 2), Parkinson's Disease (Approved) | Newron, Zambon Company S.p.A. | Other Neurotransmitters | Small Molecule | |
SAGE-718 | Dalzanemdor | Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Huntington's Disease (Phase 2) | Sage Therapeutics, Inc. | Other Neurotransmitters | Small Molecule | |
SAR110894D | Alzheimer's Disease (Phase 2) | Sanofi | Other | Small Molecule | ||
SAR228810 | Alzheimer's Disease (Discontinued) | Sanofi | Amyloid-Related | Immunotherapy (passive) | ||
Saracatinib | AZD0530 | Alzheimer's Disease (Discontinued), Parkinson's Disease (Phase 1) | AstraZeneca | Other | Small Molecule | |
Sargramostim | GM-CSF Leukine , Leukine® |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 1) | Genzyme, Partner Therapeutics, Inc., Sanofi | Inflammation, Other, Unknown | Other | Bone Marrow Stimulation |
SB 202026 | Memric | Alzheimer's Disease (Discontinued) | Other Neurotransmitters | Small Molecule | ||
Selnoflast | RO7486967, RG-6418, IZD-334, somalix |
Parkinson's Disease (Phase 1) | Hoffmann-La Roche, Inflazome Ltd. | Inflammation | Small Molecule | |
Seltorexant | JNJ-42847922, MIN-202 |
Alzheimer's Disease (Phase 2) | Janssen | Other | Small Molecule | |
Semagacestat | LY450139 Dihydrate , hydroxylvaleryl monobenzocaprolactam |
Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Small Molecule | None |
Semaglutide | Ozempic, Wegovy, Rybelsus |
Alzheimer's Disease (Phase 3), Parkinson's Disease (Phase 2) | Novo Nordisk A/S | Other | Other | Type 2 Diabetes, Obesity, Protection against myocardial infarction and stroke |
Sembragiline | RO4602522, RG1577 |
Alzheimer's Disease (Discontinued) | Evotech AG | Other Neurotransmitters, Other | Small Molecule | |
Semorinemab | RO7105705 , MTAU9937A, RG6100 |
Alzheimer's Disease (Phase 2) | AC Immune SA, Genentech, Hoffmann-La Roche | Tau | Immunotherapy (passive) | |
Sensory Stimulation Systems | GENUS, Gamma entrainment using sensory stimuli, GammaSense Stimulation |
Alzheimer's Disease (Phase 3), Parkinson's Disease (Not Regulated), Down's Syndrome (Not Regulated) | Cognito Therapeutics, Inc. | Amyloid-Related, Inflammation, Other | Combination, Procedural Intervention | |
SGS-742 | CGP-36742, DVD-742 |
Alzheimer's Disease (Discontinued) | Novartis Pharmaceuticals Corporation, Saegis Pharmaceuticals, Inc. | Other Neurotransmitters | Small Molecule | |
Simufilam | PTI-125, sumifilam |
Alzheimer's Disease (Phase 3) | Cassava Sciences | Amyloid-Related | Small Molecule | |
Simvastatin | Zocor®, Lipex®, Lipovas®, Denan® |
Alzheimer's Disease (Inactive), Mild Cognitive Impairment (Phase 4) | Merck | Cholesterol | Small Molecule | Hypercholesterolemia and diabetic cardiomyopathy. |
SNP318 | Alzheimer's Disease (Phase 1) | SciNeuro Pharmaceuticals | Inflammation | Small Molecule | ||
Solanezumab | LY2062430 | Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | None |
Souvenaid | Fortasyn Connect | Alzheimer's Disease (Not Regulated) | Nutricia | Other | Supplement, Dietary | |
ST101 | ZSET1446 | Alzheimer's Disease (Inactive) | Sonexa Therapeutics, Inc. | Unknown | Small Molecule | |
Suritozole | MD 26479 | Alzheimer's Disease (Discontinued) | Aventis Pharmaceuticals, Inc. (was Hoechst) | Other Neurotransmitters | Small Molecule | |
SUVN-G3031 | Samelisant, 17v |
Alzheimer's Disease (Phase 1) | Suven Life Sciences Ltd | Cholinergic System, Other Neurotransmitters | Small Molecule | |
Suvorexant | Belsomra, MK-4305 |
Alzheimer's Disease (Approved) | Merck | Other | Small Molecule | Insomnia, Insomnia in mild to moderate Alzheimer's disease |
T3D-959 | DB959 | Alzheimer's Disease (Phase 2) | T3D Therapeutics, Inc. | Other | Small Molecule | |
Tacrine | Cognex™ | Alzheimer's Disease (Approved) | Pfizer, Shionogi Pharma | Cholinergic System | Small Molecule | |
TAK-341 | MEDI1341 | Parkinson's Disease (Phase 1), Multiple System Atrophy (Phase 2) | AstraZeneca, Takeda Pharmaceutical Company | alpha-synuclein | Immunotherapy (passive) | |
TB006 | Alzheimer's Disease (Phase 1) | TrueBinding, Inc. | Inflammation | Immunotherapy (passive) | ||
Telmisartan | Micardis | Alzheimer's Disease (Phase 2) | Boehringer Ingelheim | Other | Small Molecule | Hypertension |
Thalidomide | Thalomid® | Alzheimer's Disease (Discontinued) | Celgene Corporation | Amyloid-Related, Inflammation | Small Molecule | |
Tideglusib | NP031112, Nypta® , Zentylor™ , Glycogen synthase kinase 3 inhibitor, NP12 |
Alzheimer's Disease (Discontinued), Progressive Supranuclear Palsy (Discontinued) | Zeltia Group | Tau | Small Molecule | |
Tilavonemab | ABBV-8E12, C2N 8E12, HJ8.5 |
Progressive Supranuclear Palsy (Discontinued), Alzheimer's Disease (Discontinued) | AbbVie, C2N Diagnostics, LLC | Tau | Immunotherapy (passive) | |
TPI 287 | Alzheimer's Disease (Inactive), Corticobasal Degeneration (Inactive), Progressive Supranuclear Palsy (Phase 1) | Cortice Biosciences | Tau | Small Molecule | ||
TPN-101 | OBP-601, BMS-986001, censavudine, festinavir, 4'-ethynyl stavudine, 4'-ethynyl-d4T |
ALS-FTD (Phase 2), Progressive Supranuclear Palsy (Phase 2) | Transposon Therapeutics | Inflammation | Small Molecule, DNA/RNA-based | |
Trappsol® Cyclo™ | HP-beta-CD, HPbetaCD |
Alzheimer's Disease (Phase 2) | Cyclo Therapeutics, Inc. | Cholesterol | Other | |
Trazodone | Trazodone hydrochloride, Oleptro, Desyrel |
Alzheimer's Disease (Phase 3), Mild Cognitive Impairment (Phase 3), Amyotrophic Lateral Sclerosis (Phase 2/3) | Other Neurotransmitters | Small Molecule | Depression | |
Tricaprilin | AC-1204 , Caprylic triglyceride, AC-SD-03, CER-000, AC-OLE-O1-VA |
Alzheimer's Disease (Phase 3) | Cerecin Pte. Ltd. | Other | Supplement, Dietary, Other | None |
Trontinemab | RO7126209, RG6102 , Brain shuttle gantenerumab |
Alzheimer's Disease (Phase 1/2) | Hoffmann-La Roche | Amyloid-Related | Immunotherapy (passive) | |
Troriluzole | BHV-4157, trigriluzole, FC-4157 | Alzheimer's Disease (Discontinued) | Biohaven Pharmaceuticals | Other Neurotransmitters | Other | |
TW001 | FNP122, FAB122, oral edaravone |
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 3) | Treeway B.V. | Other | Small Molecule | |
UB-311 | Alzheimer's Disease (Phase 2) | United Neuroscience, Vaxxinity | Amyloid-Related | Immunotherapy (active) | ||
UB-312 | Parkinson's Disease (Phase 2) | United Neuroscience, Vaxxinity | alpha-synuclein | Immunotherapy (active) | ||
UCB0022 | Parkinson's Disease (Phase 2) | UCB S.A. | Other Neurotransmitters | Small Molecule | ||
UCB7853 | Parkinson's Disease (Phase 1) | UCB S.A. | alpha-synuclein | Immunotherapy (passive) | ||
Ulefnersen | ION363, Jacifusen |
Amyotrophic Lateral Sclerosis (Phase 3) | IONIS Pharmaceuticals | Other | DNA/RNA-based | |
Umibecestat | CNP520, BACE Inhibitor |
Alzheimer's Disease (Discontinued) | Amgen, Inc., Novartis Pharmaceuticals Corporation | Amyloid-Related | Small Molecule | |
Vafidemstat | ORY-2001 | Alzheimer's Disease (Phase 2) | Oryzon Corporate | Other Neurotransmitters | Small Molecule | |
Valacyclovir | Valtrex, Valaciclovir, 256U87 |
Alzheimer's Disease (Phase 2) | GlaxoSmithKline (GSK) | Other | Small Molecule | Herpes virus outbreaks |
Valproate | Depakote, Depakene, Valproic acid , Divalproex sodium |
Alzheimer's Disease (Inactive) | Abbott Laboratories | Other Neurotransmitters | Small Molecule | Epilepsy, Bipolar disorder, Migraine |
Vanutide cridificar | ACC-001, PF-05236806 |
Alzheimer's Disease (Discontinued) | Janssen | Amyloid-Related | Immunotherapy (active) | None |
Varenicline | Champix™, Chantix™, Varenicline tartrate, CP-526,555, Alpha4 beta2 nicotinic receptor agonist |
Alzheimer's Disease (Discontinued) | Pfizer | Cholinergic System | Small Molecule | Smoking cessation |
Varoglutamstat | PQ912 | Alzheimer's Disease (Discontinued) | Probiodrug AG, Vivoryon Therapeutics N.V. | Amyloid-Related, Inflammation | Small Molecule | |
Vascepa | Icosapent ethyl (IPE), Ethyl eicosapentaenoic acid (E-EPA), AMR101, Miraxion |
Alzheimer's Disease (Phase 2/3) | Other | Small Molecule | Severe hypertriglyceridemia, and to lower risk of cardiovascular events in people with elevated triglycerides | |
Venglustat | Ibiglustat, GZ/SAR402671, Genz-682452 |
Parkinson's Disease (Inactive) | Genzyme, Sanofi | alpha-synuclein, Other | Small Molecule | |
Verdiperstat | AZD3241, BHV-3241 |
Motor Neuron Disease (Discontinued), Multiple System Atrophy (Discontinued), Primary Progressive Aphasia (Phase 1) | AstraZeneca, Biohaven Pharmaceuticals | Inflammation, Other | Small Molecule | |
Verubecestat | MK-8931, MK-8931-009 , BACE inhibitor |
Alzheimer's Disease (Discontinued) | Merck | Amyloid-Related | Small Molecule | |
VG-3927 | Alzheimer's Disease (Phase 1) | Vigil Neuroscience, Inc. | Amyloid-Related, Inflammation | Small Molecule | ||
VGL101 | Adult-onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (Phase 1) | Vigil Neuroscience, Inc. | Inflammation, Other | Immunotherapy (passive) | ||
Vodobatinib | K0706, SCC-138, SCO-088 |
Parkinson's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2) | Sun Pharma Advanced Research Company Ltd. | Other | Small Molecule | |
VY-AADC | VY-AADC01, VY-AADC02 |
Parkinson's Disease (Discontinued) | Neurocrine Biosciences, Voyager Therapeutics | Other Neurotransmitters | DNA/RNA-based | |
VY-TAU01 | HC3LC2, Voyager_9 |
Alzheimer's Disease (Phase 1) | Voyager Therapeutics | Tau | Immunotherapy (passive) | |
WVE-004 | Frontotemporal Dementia (Discontinued), Amyotrophic Lateral Sclerosis (Discontinued) | Wave Life Sciences USA, Inc. | Other | DNA/RNA-based | ||
Xaliproden | SR 57746A | Alzheimer's Disease (Discontinued) | Sanofi | Other Neurotransmitters, Other | Small Molecule | |
Xanamem | UE 2343 | Alzheimer's Disease (Phase 2) | Actinogen Medical | Other | Small Molecule | |
XPro1595 | Pegipanermin, INB03, NeuLiv, XENP1595, DN-TNF, XENP345, XPro™ , LIVNate |
Alzheimer's Disease (Phase 2), Mild Cognitive Impairment (Phase 2) | INmune Bio Inc. | Inflammation | Other | |
Young Plasma | Progressive Supranuclear Palsy (Inactive), Alzheimer's Disease (Inactive) | Alkahest, Inc., Grifols Biologicals Inc. | Inflammation, Other, Unknown | Other | ||
YTX-7739 | Parkinson's Disease (Phase 1) | Yumanity Therapeutics | Other | Small Molecule | ||
Zagotenemab | LY3303560 | Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Tau, Unknown | Immunotherapy (passive) |