Therapeutics
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| Name | Synonyms | FDA Status | Company | Target Type | Therapy Type | Approved For |
|---|---|---|---|---|---|---|
| AAB-003 | PF-05236812 | Alzheimer's Disease (Discontinued) | Janssen, Pfizer | Amyloid-Related | Immunotherapy (passive) | |
| AADvac1 | Axon peptide 108 conjugated to KLH | Alzheimer's Disease (Phase 2), Progressive Nonfluent Aphasia (Phase 1) | Axon Neuroscience SE | Tau | Immunotherapy (active) | |
| ABBV-0805 | BAN0805 | Parkinson's Disease (Phase 1) | AbbVie, BioArctic AB | alpha-synuclein | Immunotherapy (passive) | |
| ABBV-CLS-7262 | Amyotrophic Lateral Sclerosis (Phase 1) | Other | Small Molecule | |||
| ABT 418 | Alzheimer's Disease (Discontinued) | Cholinergic System | Small Molecule | None | ||
| ABT-089 | Alzheimer's Disease (Discontinued) | Abbott Laboratories | Cholinergic System | Small Molecule | ||
| ABT-288 | Alzheimer's Disease (Discontinued) | AbbVie | Cholinergic System, Other Neurotransmitters | Small Molecule | ||
| ABT-384 | Alzheimer's Disease (Discontinued) | AbbVie | Other | Small Molecule | ||
| ABT-957 | Alzheimer's Disease (Phase 1) | AbbVie | Other | Small Molecule | ||
| ABvac 40 | Alzheimer's Disease (Phase 2) | Araclon Biotech | Amyloid-Related | Immunotherapy (active) | ||
| ACI-24 | Pal1-15 acetate salt | Alzheimer's Disease (Phase 2), Down's Syndrome (Phase 2) | AC Immune SA | Amyloid-Related | Immunotherapy (active) | |
| ACI-3024 | Tau MorphomerTM | Alzheimer's Disease (Inactive), Other Tauopathy (Phase 0) | AC Immune SA | Tau | Small Molecule | |
| ACI-35 | VAC20121 | Alzheimer's Disease (Phase 2) | AC Immune SA, Janssen | Tau | Immunotherapy (active) | |
| ACU193 | ACU-193 | Alzheimer's Disease (Phase 1) | Acumen Pharmaceuticals, Inc. | Amyloid-Related | Immunotherapy (passive) | |
| AF 102B | cevimeline HCL, Evoxac™ |
Alzheimer's Disease (Discontinued) | SnowBrand Pharmaceuticals, Inc. | Cholinergic System | Small Molecule | Treatment of dry mouth in Sjogren's syndrome. |
| AGB101 | levetiracetam | MCI-AD (Phase 2/3) | AgeneBio, Inc. | Amyloid-Related | Small Molecule | |
| AKST4290 | ALK4290, lazucirnon |
Parkinson's Disease (Phase 2) | Alkahest, Inc. | Inflammation | Small Molecule | |
| AL002 | Alzheimer's Disease (Phase 2) | AbbVie, Alector | Inflammation | Immunotherapy (passive) | ||
| AL003 | Alzheimer's Disease (Discontinued) | AbbVie, Alector | Inflammation | Immunotherapy (passive) | ||
| AL101 | GSK-4527226 | Alzheimer's Disease (Phase 1) | Alector | Other | Immunotherapy (passive) | |
| ALZ-101 | Alzheimer's Disease (Phase 1) | Alzinova AB | Amyloid-Related | Immunotherapy (active) | ||
| ALZ-801 | valiltramiprosate, NRM-8499, homotaurine prodrug, 3-APS |
Alzheimer's Disease (Phase 3) | Alzheon Inc. | Amyloid-Related | Small Molecule | |
| ALZT-OP1 | Cromolyn sodium, Intal, Ibuprofen |
Alzheimer's Disease (Phase 3) | AZTherapies, Inc. | Amyloid-Related, Inflammation | Combination, Small Molecule | |
| AN-1792 | AIP 001 | Alzheimer's Disease (Discontinued) | Janssen, Pfizer | Amyloid-Related | Immunotherapy (active) | None |
| APNmAb005 | RAA7 | Alzheimer's Disease (Phase 1) | Aprinoia Therapeutics | Tau | Immunotherapy (passive) | |
| AR1001 | Alzheimer's Disease (Phase 2) | Aribio Co., Ltd. | Other | Small Molecule | ||
| ASN120290 | ASN-561 | Progressive Supranuclear Palsy (Phase 1) | Asceneuron SA | Tau | Small Molecule | |
| ASN51 | ASN121151 | Alzheimer's Disease (Phase 1) | Asceneuron SA | Tau | Small Molecule | |
| AVP-786 | Alzheimer's Disease (Phase 3), Schizophrenia (Phase 2) | Avanir Pharmaceuticals, Concert Pharmaceuticals, Inc., Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Combination, Small Molecule | ||
| AVP-923 | Nuedexta, Zenvia |
Alzheimer's Disease (Phase 4), Amyotrophic Lateral Sclerosis (Phase 3), Parkinson's Disease (Phase 3) | Avanir Pharmaceuticals, Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Combination, Small Molecule | |
| AXS-05 | Dextromethorphan/bupropion | Alzheimer's Disease (Phase 2/3) | Axsome Therapeutics, Inc. | Other Neurotransmitters | Combination, Small Molecule | |
| AZD1446 | TC-6683 | Alzheimer's Disease (Discontinued) | AstraZeneca, Targacept | Cholinergic System | Small Molecule | None |
| AZD3480 | ispronicline, TC-1734 |
Alzheimer's Disease (Inactive) | AstraZeneca, Targacept | Cholinergic System | Small Molecule | |
| AZP2006 | AZP-2006 | Progressive Supranuclear Palsy (Phase 2), Alzheimer's Disease (Phase 1) | AlzProtect | Tau, Inflammation, Other | Small Molecule | |
| Acetyl-l-carnitine HCI | ALCAR | Alzheimer's Disease (Discontinued) | Sigma-Tau Pharmaceuticals | Other | Supplement, Dietary | |
| Acitretin | Soriatane , Neotigason, RO 101670 |
Alzheimer's Disease (Phase 2) | Actavis, Allergan plc | Amyloid-Related | Small Molecule | Psoriasis in US |
| Aduhelm | Aducanumab, BIIB037 |
Alzheimer's Disease (Approved) | Biogen, Neurimmune | Amyloid-Related | Immunotherapy (passive) | |
| Affitope AD02 | Alzheimer's Disease (Discontinued) | AFFiRiS AG | Amyloid-Related | Immunotherapy (active) | ||
| Affitope PD01A, PD03A | ACI-7104 | Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 1) | AC Immune SA, AFFiRiS AG | alpha-synuclein | Immunotherapy (active) | |
| Albrioza | AMX0035 | Amyotrophic Lateral Sclerosis (Phase 2), Alzheimer's Disease (Phase 2) | Amylyx Pharmaceuticals Inc | Other | Combination, Small Molecule | |
| Allopregnanolone | brexanolone, 3α-hydroxy-5α-pregnan-20-one, 3α,5α-tetrahydroprogesterone |
Alzheimer's Disease (Phase 2) | Other Neurotransmitters, Other | Small Molecule | ||
| Alpha-Tocopherol | Vitamin E | Alzheimer's Disease (Phase 3) | Other | Supplement, Dietary | ||
| Alzhemed™ | Vivimind™, Tramiprosate, NC-531, homotaurine, 3-APS |
Alzheimer's Disease (Discontinued) | Neurochem, Inc. | Amyloid-Related | Supplement, Dietary | None |
| Ambroxol | Ambrosan, Mucosolvan | Parkinson's Disease (Phase 2), Parkinson's Disease Dementia (Phase 2), Dementia with Lewy Bodies (Phase 2) | alpha-synuclein, Other | Small Molecule | ||
| Amilomotide | CAD106 | Alzheimer's Disease (Inactive) | Novartis Pharmaceuticals Corporation | Amyloid-Related | Immunotherapy (active) | None |
| Anle138b | Parkinson's Disease (Phase 1/2) | MODAG GmbH | Tau, alpha-synuclein, Other | Small Molecule | ||
| Apabetalone | RVX208, RVX000222 |
MCI-VaD (Phase 3) | Resverlogix Corporation | Other | Small Molecule | |
| Aripiprazole | Abilify, BMS-337039 |
Alzheimer's Disease (Phase 3), Schizophrenia (Approved) | Bristol-Myers Squibb, Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Small Molecule | |
| Atabecestat | JNJ-54861911 , BACE inhibitor |
Alzheimer's Disease (Discontinued) | Janssen, Shionogi Pharma | Amyloid-Related | Small Molecule | |
| Atomoxetine | ATX, Strattera |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 1) | Eli Lilly & Co. | Other Neurotransmitters | Small Molecule | ADHD in US |
| Atorvastatin | Lipitor™ , Zarator®, Sortis®, Tahor® |
Alzheimer's Disease (Inactive) | Pfizer | Cholesterol | Small Molecule | Hypercholesterolaemia |
| Atuzaginstat | COR388 | Alzheimer's Disease (Inactive) | Cortexyme, Inc. | Other | Small Molecule | |
| Avagacestat | BMS-708163 | Alzheimer's Disease (Discontinued) | Bristol-Myers Squibb | Amyloid-Related | Small Molecule | |
| Azeliragon | PF-04494700, TTP488 |
Alzheimer's Disease (Discontinued) | Pfizer, TransTech Pharma, Inc., vTv Therapeutics LLC | Amyloid-Related, Inflammation | Small Molecule | |
| BI 1181181 | VTP 37948, BACE inhibitor |
Alzheimer's Disease (Discontinued) | Boehringer Ingelheim, Vitae Pharmaceuticals | Amyloid-Related | Small Molecule | |
| BI 409306 | SUB 166499 | Alzheimer's Disease (Discontinued), Schizophrenia (Phase 2) | Boehringer Ingelheim | Other Neurotransmitters, Other | Small Molecule | |
| BI 425809 | Alzheimer's Disease (Discontinued), Schizophrenia (Phase 2) | Boehringer Ingelheim | Other Neurotransmitters | Small Molecule | ||
| BIIB076 | NI-105, 6C5 huIgG1/l |
Alzheimer's Disease (Discontinued) | Biogen, Eisai Co., Ltd., Neurimmune | Tau | Immunotherapy (passive) | |
| BIIB078 | BIIB-078, IONIS-C9Rx |
Amyotrophic Lateral Sclerosis (Discontinued) | Biogen, IONIS Pharmaceuticals | Other | DNA/RNA-based | |
| BIIB080 | IONIS-MAPTRx, ISIS 814907 |
Alzheimer's Disease (Phase 1) | Biogen, IONIS Pharmaceuticals | Tau | DNA/RNA-based | |
| BIIB094 | ION859, IONIS-BIIB7Rx |
Parkinson's Disease (Phase 1) | Biogen, IONIS Pharmaceuticals | Inflammation, Other | DNA/RNA-based | |
| BIIB100 | KPT-350 | Amyotrophic Lateral Sclerosis (Discontinued) | Biogen | Inflammation, Other | Small Molecule | |
| BIIB105 | ION541 | Amyotrophic Lateral Sclerosis (Phase 1) | Biogen, IONIS Pharmaceuticals | Other | DNA/RNA-based | |
| BIIB118 | PF-05251749 | Alzheimer's Disease (Phase 1), Parkinson's Disease (Phase 1) | Biogen | Other | Small Molecule | |
| BPN14770 | Alzheimer's Disease (Phase 2) | Shionogi Pharma, Tetra Therapeutics | Cholinergic System, Other | Small Molecule | ||
| Bapineuzumab | AAB-001 | Alzheimer's Disease (Discontinued) | Janssen, Pfizer | Amyloid-Related | Immunotherapy (passive) | |
| Baricitinib | Olumiant®, NCB28050, LY3009104 |
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 1) | Eli Lilly & Co. | Inflammation | Small Molecule | Rheumatoid arthritis, Eczema (Europe, Japan only) |
| Bepranemab | UCB0107 , UCB 0107 , Antibody D |
Progressive Supranuclear Palsy (Phase 1), Alzheimer's Disease (Phase 2) | Hoffmann-La Roche, UCB S.A. | Tau | Immunotherapy (passive) | |
| Besipirdine HCl | HP 749 | Alzheimer's Disease (Discontinued) | Aventis Pharmaceuticals, Inc. (was Hoechst) | Other Neurotransmitters | Small Molecule | |
| Bexarotene | Targretin® | Alzheimer's Disease (Phase 2) | Ligand Pharmaceuticals, Inc., ReXceptor Inc. | Amyloid-Related, Unknown | Small Molecule | Cutaneous T-cell Lymphoma in US |
| Bifidobacterium breve A1 | MCC1274, B. breve |
Mild Cognitive Impairment (Phase 2) | Morinaga Milk Industry Co., Ltd | Other | Supplement, Dietary | |
| Blarcamesine | Anavex 2-73 | Alzheimer's Disease (Phase 2/3), Parkinson's Disease Dementia (Phase 2), Parkinson's Disease (Phase 1) | Anavex Life Science Corp. | Other | Small Molecule | |
| Bosutinib | BOSULIF®, PF-5208763, SKI-606 |
Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2) | Pfizer | Other | Small Molecule | Chronic myeloid leukemia |
| Brexpiprazole | Rexulti, OPC 34712 |
Alzheimer's Disease (Phase 3), Schizophrenia (Approved) | Lundbeck, Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Small Molecule | |
| Bryostatin 1 | Alzheimer's Disease (Phase 2) | Synaptogenix, Inc. | Other | Other | ||
| CDNF | cerebral dopamine neurotrophic factor | Parkinson's Disease (Phase 1/2) | Herantis Pharma Plc, Renishaw plc. | Other | Procedural Intervention, Other | |
| CERE-110 | Nerve Growth Factor gene therapy | Alzheimer's Disease (Discontinued) | Sangamo BioSciences, Inc. | Other | DNA/RNA-based | |
| CHF 5074 | Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Inactive) | CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. | Amyloid-Related, Inflammation, Other | Small Molecule | ||
| CNM-Au8 | Gold nanocrystals | Parkinson's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 2/3) | Clene Nanomedicine, Inc. | Metals, Other | Other | |
| COGNIShunt™ | Alzheimer's Disease (Inactive) | Other | Procedural Intervention | None | ||
| CST-2032 | Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2) | Other Neurotransmitters | Small Molecule | |||
| CVN424 | Parkinson's Disease (Phase 2) | Cerevance | Other Neurotransmitters | Small Molecule | ||
| CX516 | Ampalex | Alzheimer's Disease (Discontinued) | Cortex Pharmaceuticals, Inc. | Other Neurotransmitters | Small Molecule | None |
| Candesartan | Atacand, Candesartan cilexetil |
Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Phase 2) | AstraZeneca, Takeda Pharmaceutical Company | Other | Small Molecule | Hypertension, congestive heart failure |
| Cannabidiol | CBD, Epidiolex |
Alzheimer's Disease (Phase 2) | Other Neurotransmitters | Small Molecule | Seizures in Dravet syndrome, Lennox-Gastaut syndrome or tuberous sclerosis complex | |
| Carvedilol | Coreg, Artist , Aucardic, Dilatrend, Kredex |
Alzheimer's Disease (Phase 4) | Procter & Gamble | Unknown | Small Molecule | Hypertension, heart failure, angina pectoris |
| Celecoxib | Celebrex | Alzheimer's Disease (Discontinued) | Pfizer | Inflammation | Small Molecule | Pain, Arthritis |
| Cerebrolysin | Alzheimer's Disease (Phase 2) | Ebewe Pharmaceutical | Other | Other | ||
| Cinpanemab | BIIB054, NI-202 |
Parkinson's Disease (Discontinued) | Biogen, Neurimmune | alpha-synuclein | Immunotherapy (passive) | |
| Circadin | Alzheimer's Disease (Phase 2) | Neurim Pharmaceuticals Ltd. | Other | Small Molecule | Insomnia | |
| Citalopram | escitalopram, Celexa, Lexapro , Cipralex |
Alzheimer's Disease (Phase 3), Preclinical Alzheimer's Disease (Inactive) | Other Neurotransmitters | Small Molecule | Depression, generalized anxiety disorder | |
| Clenbuterol | CST-103 | Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 2) | Other Neurotransmitters | Small Molecule | Asthma, in countries outside the U.S. | |
| Clioquinol | iodochlorhydroxyquin, PBT-1 |
Alzheimer's Disease (Discontinued) | Prana Biotechnology Limited | Amyloid-Related, Metals | Small Molecule | |
| Cocoa Flavanols | Mild Cognitive Impairment (Not Regulated) | Inflammation, Other | Supplement, Dietary | |||
| Continuous Positive Airway Pressure | CPAP | Alzheimer's Disease (Phase 3) | Unknown | Procedural Intervention | Sleep Apnea in US | |
| Contraloid | PRI-002, contraloid acetate, RD2 |
Alzheimer's Disease (Phase 1) | Priavoid GmbH | Amyloid-Related | Small Molecule | |
| Crenezumab | MABT5102A , RG7412 |
Alzheimer's Disease (Phase 3) | AC Immune SA, Genentech, Hoffmann-La Roche | Amyloid-Related | Immunotherapy (passive) | None |
| Curcumin | diferuloylmethane, Longvida™ |
Alzheimer's Disease (Phase 2) | Verdure Sciences | Other, Unknown | Supplement, Dietary | None |
| DAYVIGO | Lemborexant, E2006 |
Alzheimer's Disease (Phase 2) | Eisai Co., Ltd. | Other | Small Molecule | Insomnia |
| DNL151 | BIIB122 | Parkinson's Disease (Phase 1) | Biogen, Denali Therapeutics Inc. | Inflammation, Other | Small Molecule | |
| DNL201 | Parkinson's Disease (Inactive) | Biogen, Denali Therapeutics Inc. | Inflammation, Other | Small Molecule | ||
| DNL343 | Amyotrophic Lateral Sclerosis (Phase 1) | Denali Therapeutics Inc. | Other | Small Molecule | ||
| DNL593 | PTV:PGRN | Frontotemporal Dementia (Phase 1/2) | Denali Therapeutics Inc., Takeda Pharmaceutical Company | Other | Other | |
| DNL747 | SAR 443060 | Alzheimer's Disease (Inactive), Amyotrophic Lateral Sclerosis (Inactive) | Denali Therapeutics Inc., Sanofi | Inflammation | Small Molecule | |
| Dapagliflozin | Farxiga, Forxiga, BMS 512148 |
Alzheimer's Disease (Phase 1/2) | AstraZeneca, Bristol-Myers Squibb | Other | Small Molecule | |
| Dapsone | Avlosulfon, Diaminodiphenylsulfone, DDS |
Alzheimer's Disease (Inactive) | Immune Network Ltd. | Other | Small Molecule | Leprosy, malaria, some bacterial skin infections |
| Dasatinib + Quercetin | Alzheimer's Disease (Phase 1/2) | Tau, Other | Combination, Small Molecule, Supplement, Dietary | |||
| Davunetide | NAP, AL-108 |
Mild Cognitive Impairment (Discontinued), Progressive Supranuclear Palsy (Discontinued), Schizophrenia (Discontinued), Frontotemporal Dementia (Inactive) | Allon Therapeutics Inc., Paladin Labs Inc. | Tau | Other | |
| Deep Brain Stimulation-fornix | Alzheimer's Disease (Phase 2) | Functional Neuromodulation Ltd | Unknown | Procedural Intervention | ||
| Deferiprone | Ferriprox | Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 2/3), Amyotrophic Lateral Sclerosis (Phase 2) | Apotex Inc., Chiesi Pharmaceuticals Inc. | Metals | Small Molecule | Iron overload due to thalassemia syndromes |
| Dexpramipexole | R-pramipexole, RPPX, KNS-760704 , BIIB 050 |
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) | Biogen, Knopp Biosciences LLC, Virginia Commonwealth University | Other Neurotransmitters, Other | Small Molecule | |
| Dimebon | Dimebolin, Latrepirdine, Pf-01913539 |
Alzheimer's Disease (Discontinued), Huntington's Disease (Discontinued) | Medivation, Inc. | Other Neurotransmitters, Unknown | Small Molecule | Anti-histamine use in Russia |
| Dipraglurant | ADX48621 | Parkinson's Disease (Phase 2/3) | Addex Therapeutics | Other Neurotransmitters | Small Molecule | |
| Docosahexaenoic acid (DHA) | Omega 3 fatty acid | Alzheimer's Disease (Phase 4) | Martek Biosciences Corporation, NeuroBioPharm, Inc. | Other | Supplement, Dietary | |
| Donanemab | N3pG-Aβ Monoclonal Antibody, LY3002813 |
Alzheimer's Disease (Phase 3) | Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | |
| Donepezil | Aricept™, Donepezil hydrochloride, Eranz®, E 2020 |
Alzheimer's Disease (Approved), Dementia with Lewy Bodies (Inactive), Down's Syndrome (Inactive), Parkinson's Disease Dementia (Inactive) | Corium, Inc., Eisai Co., Ltd., Pfizer | Cholinergic System | Small Molecule | Alzheimer's Disease, Dementia with Lewy Bodies (Japan) |
| Dronabinol | THC , Marinol, Syndros, delta-9-tetrahydrocannabinol, delta-9-THC |
Alzheimer's Disease (Phase 2) | AbbVie, Others | Other Neurotransmitters | Small Molecule | Anorexia and weight loss in people with AIDS; Second-line treatment of nausea and vomiting due to chemotherapy |
| E2027 | Dementia with Lewy Bodies (Phase 2) | Eisai Co., Ltd. | Other | Small Molecule | ||
| E2814 | Alzheimer's Disease (Phase 1/2) | Eisai Co., Ltd. | Tau | Immunotherapy (passive) | ||
| EHT 0202 | Etazolate | Alzheimer's Disease (Phase 2) | ExonHit Therapeutics | Other | Small Molecule | None |
| ELND005 | AZD-103, Scyllo-inositol, cyclohexane-1,2,3,4,5,6-hexol |
Alzheimer's Disease (Inactive) | Elan Corporation, Opko Health, Speranza Therapeutics, Transition Therapeutics, Inc. | Amyloid-Related | Small Molecule | None |
| EVP-0962 | EVP 0015962 | Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) | FORUM Pharmaceuticals Inc. | Amyloid-Related | Small Molecule | |
| Edaravone | MCI-186, Radicava®, Radicut®, MT-1186 |
Amyotrophic Lateral Sclerosis (Phase 4) | Mitsubishi Tanabe Pharma | Other | Small Molecule | Amyotrophic Lateral Sclerosis |
| Edicotinib | JNJ-40346527, JNJ-527, PRV-6527 |
Alzheimer's Disease (Phase 1) | Janssen | Inflammation | Small Molecule | |
| Edonerpic | T-817 MA, T 817 | Alzheimer's Disease (Phase 2) | Toyama Chemical Co., Ltd. | Other, Unknown | Small Molecule | |
| Elayta | CT1812 | Alzheimer's Disease (Phase 2) | Cognition Therapeutics Inc. | Amyloid-Related | Small Molecule | |
| Elenbecestat | E2609, BACE inhibitor |
Alzheimer's Disease (Discontinued) | Biogen, Eisai Co., Ltd. | Amyloid-Related | Small Molecule | |
| Empagliflozin | Jardiance, BI-10773 |
Alzheimer's Disease (Phase 1) | Boehringer Ingelheim, Eli Lilly & Co. | Other | Small Molecule | Type 2 Diabetes, Cardiovascular disease |
| Encenicline | EVP-6124 , MT-4666, α7-nAChR agonist |
Alzheimer's Disease (Discontinued), Schizophrenia (Discontinued) | FORUM Pharmaceuticals Inc., Mitsubishi Tanabe Pharma | Cholinergic System | Small Molecule | None |
| Epigallocatechin Gallate (EGCG) | Sunphenon EGCg | Alzheimer's Disease (Phase 2/3), Down's Syndrome (Phase 2), Multiple System Atrophy (Phase 3) | Taiyo International | Amyloid-Related, Inflammation, Other | Supplement, Dietary | |
| Epothilone D | BMS-241027 | Alzheimer's Disease (Discontinued) | Bristol-Myers Squibb | Tau | Small Molecule | |
| Eptastigmine | MF 201 | Alzheimer's Disease (Discontinued) | Mediolanum | Cholinergic System | Small Molecule | None |
| Estrogen | Premarin™ | Alzheimer's Disease (Discontinued) | Other | Other | Hormone Replacement Therapy | |
| Etanercept | Enbrel™ | Alzheimer's Disease (Phase 2) | Amgen, Inc., Pfizer | Inflammation | Immunotherapy (passive) | Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondilysis |
| Exenatide | Exendin-4, Byetta, Bydureon |
Alzheimer's Disease (Inactive), Parkinson's Disease (Phase 3) | Other | Small Molecule | Diabetes mellitus in US | |
| FRM-0334 | EVP-0334 | Frontotemporal Dementia (Discontinued) | FORUM Pharmaceuticals Inc. | Other | Small Molecule | |
| Flurizan™ | tarenflurbil , r-flurbiprofen, MPC-7869 |
Alzheimer's Disease (Discontinued) | Myriad Genetics & Laboratories | Amyloid-Related | Small Molecule | None |
| Fosgonimeton | ATH-1017, NDX-1017 |
Alzheimer's Disease (Phase 2/3), Dementia with Lewy Bodies (Phase 2), Parkinson's Disease Dementia (Phase 2) | Athira Pharma | Other | Small Molecule | |
| G-CSF | Filgrastim | Alzheimer's Disease (Phase 2) | Other | Small Molecule | Neutropenia in US | |
| GC 021109 | Alzheimer's Disease (Phase 1) | GliaCure | Inflammation | Small Molecule | ||
| GENUS | Gamma entrainment using sensory stimuli, GammaSense Stimulation |
Alzheimer's Disease (Phase 2) | Cognito Therapeutics, Inc. | Amyloid-Related, Inflammation, Other | Combination, Procedural Intervention | |
| GLN-1062 | Memogain | Alzheimer's Disease (Phase 1) | Galantos Pharma, Neurodyn | Cholinergic System | Small Molecule | |
| GRF6019 | Alzheimer's Disease (Phase 2) | Alkahest, Inc., Grifols Biologicals Inc. | Inflammation, Other, Unknown | Other | ||
| GRF6021 | AKST/GRF6021 | Parkinson's Disease Dementia (Phase 2) | Alkahest, Inc., Grifols Biologicals Inc. | Inflammation, Other, Unknown | Other | |
| GSK239512 | Alzheimer's Disease (Discontinued) | GlaxoSmithKline (GSK) | Cholinergic System, Other Neurotransmitters | Small Molecule | ||
| GSK2647544 | GSK-2647544 | Alzheimer's Disease (Phase 1) | GlaxoSmithKline (GSK) | Cholesterol | Small Molecule | |
| GSK933776 | Alzheimer's Disease (Inactive) | GlaxoSmithKline (GSK) | Amyloid-Related | Immunotherapy (passive) | ||
| GV-971 | sodium oligomannate, sodium oligo-mannurarate |
Alzheimer's Disease (Inactive) | Shanghai Green Valley Pharmaceuticals | Amyloid-Related, Inflammation | Small Molecule | |
| GV1001 | RIAVAXTM, Tertomotide | Alzheimer's Disease (Phase 2) | GemVax & KAEL Bio | Other | Immunotherapy (active) | Pancreatic cancer (Korea) |
| Galantamine | Razadyne™, Reminyl™, Nivalin® |
Alzheimer's Disease (Approved) | Janssen, Ortho-McNeil Pharmaceutical, Sanochemia Pharmazeutika, Shire, Takeda Pharmaceutical Company | Cholinergic System | Small Molecule | Mild to Moderate Alzheimer's disease |
| Gammagard® | Intravenous Immunoglobulin, IVIg |
Alzheimer's Disease (Discontinued) | Baxter Healthcare | Amyloid-Related, Inflammation | Immunotherapy (passive) | Immunodeficiency conditions |
| Gamunex | Intravenous Immunoglobulin, Human Albumin Combined With Flebogamma |
Alzheimer's Disease (Phase 2/3) | Grifols Biologicals Inc. | Amyloid-Related, Inflammation | Combination, Immunotherapy (passive) | Immunodeficiency, chronic inflammatory demyelinating neuropathy |
| Gantenerumab | RO4909832, RG1450 |
Alzheimer's Disease (Phase 3) | Chugai Pharmaceutical Co., Ltd., Hoffmann-La Roche | Amyloid-Related | Immunotherapy (passive) | |
| Gemfibrozil | Lopid, Jezil, Gen-Fibro |
Alzheimer's Disease (Phase 1) | Cholesterol | Small Molecule | Hyperlipidemia | |
| Gosuranemab | BIIB092, BMS-986168, IPN007 |
Progressive Supranuclear Palsy (Discontinued), Alzheimer's Disease (Discontinued) | Biogen, Bristol-Myers Squibb | Tau | Immunotherapy (passive) | |
| Guanfacine | Intuniv, SPD503, Afken, Estulic, Tenex |
Alzheimer's Disease (Phase 3) | Other Neurotransmitters | Small Molecule | Attention-deficit hyperactivity disorder, hypertension | |
| HF0220 | Alzheimer's Disease (Discontinued) | Newron | Inflammation | Small Molecule | ||
| HTL0018318 | Alzheimer's Disease (Inactive), Dementia with Lewy Bodies (Inactive) | Allergan plc, Sosei Heptares | Cholinergic System | Small Molecule | ||
| Huperzine A | ZT-1, DEBIO 9902 , Qian ceng ta, Cerebra capsule, Pharmassure Memorall capsule |
Alzheimer's Disease (Inactive) | Debiopharm Group™, Neuro-Hitech, Inc. | Cholinergic System | Small Molecule, Supplement, Dietary | None |
| ION363 | Jacifusen | Amyotrophic Lateral Sclerosis (Phase 3) | IONIS Pharmaceuticals | Other | DNA/RNA-based | |
| Ibuprofen | Advil™, Nuprin™ , Motrin™ |
Alzheimer's Disease (Discontinued) | Amyloid-Related, Inflammation | Small Molecule | Pain and Fever | |
| Idalopirdine | Lu AE58054, SGS 518 |
Alzheimer's Disease (Discontinued), Schizophrenia (Inactive) | Lundbeck, Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Small Molecule | |
| Idebenone | Catena, Sovrima |
Alzheimer's Disease (Discontinued) | Takeda Pharmaceutical Company | Other | Small Molecule | None |
| Intepirdine | RVT-101, SB 742457 , GSK 742457 |
Alzheimer's Disease (Discontinued), Dementia with Lewy Bodies (Discontinued) | Axovant Sciences Ltd. | Other Neurotransmitters | Small Molecule | |
| Inzomelid | Alzheimer's Disease (Phase 1), Parkinson's Disease (Phase 1) | Inflazome Ltd. | Inflammation | Small Molecule | ||
| JNJ-63733657 | Mild AD (Phase 2) | Janssen | Tau | Immunotherapy (passive) | ||
| KarXT | xanomeline-trospium | Alzheimer's Disease (Phase 3) | Karuna Therapeutics | Cholinergic System | Combination, Small Molecule | |
| Ketasyn | Axona, Caprylic Acid, AC-1202 |
Alzheimer's Disease (Phase 4) | Cerecin Pte. Ltd. | Other | Supplement, Dietary | |
| Kynmobi | APL-130277, apomorphine hydrochloride sublingual thin film |
Parkinson's Disease (Approved) | Sunovion Pharmaceuticals Inc. | Other Neurotransmitters | Small Molecule | |
| LM11A-31-BHS | LM11A-31 | Alzheimer's Disease (Phase 2) | PharmatrophiX | Other | Small Molecule | |
| LMTM | TRx0237, LMT-X, Methylene Blue, Tau aggregation inhibitor (TAI) |
Alzheimer's Disease (Phase 3), Frontotemporal Dementia (Phase 3) | TauRx Therapeutics Ltd | Tau | Small Molecule | Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia. |
| LTI-291 | Parkinson's Disease (Phase 2) | Lysosomal Therapeutics Inc. | Other | Small Molecule | ||
| LU AF82422 | Parkinson's Disease (Phase 1) | Genmab A/S, Lundbeck | alpha-synuclein | Immunotherapy (passive) | ||
| LU25-109 | Alzheimer's Disease (Discontinued) | Cholinergic System | Small Molecule | None | ||
| LX1001 | AAVrh.10-APOE2, AAVrh.10hAPOE2 |
Alzheimer's Disease (Phase 1) | Lexeo Therapeutics | Amyloid-Related | DNA/RNA-based | |
| LY2599666 | Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | ||
| LY2886721 | BACE inhibitor | Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Small Molecule | |
| LY3202626 | BACE Inhibitor | Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Small Molecule | |
| LY3372689 | Alzheimer's Disease (Phase 2) | Eli Lilly & Co. | Tau | Small Molecule | ||
| LY3372993 | N3pG-Abeta mAb | Alzheimer's Disease (Phase 1) | Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | |
| Ladostigil | Ladostigil hemitartrate, TV3326 |
Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Discontinued) | Avraham Pharmaceuticals Ltd | Cholinergic System | Small Molecule | |
| Lanabecestat | AZD3293 , LY3314814, BACE inhibitor |
Alzheimer's Disease (Discontinued) | AstraZeneca, Eli Lilly & Co. | Amyloid-Related | Small Molecule | |
| Latozinemab | AL001, GSK4527223 |
Frontotemporal Dementia (Phase 3), Amyotrophic Lateral Sclerosis (Phase 2) | Alector, GlaxoSmithKline (GSK) | Other | Immunotherapy (passive) | |
| Lecanemab | BAN2401 , mAb158 |
Alzheimer's Disease (Phase 3) | Biogen, Eisai Co., Ltd. | Amyloid-Related | Immunotherapy (passive) | |
| Lenalidomide | Revlimid | Alzheimer's Disease (Phase 2) | Celgene Corporation | Amyloid-Related, Inflammation | Small Molecule | Multiple myeloma, lymphoma, myelodysplastic syndromes |
| Leuprolide | Leuprolide acetate , Lupron Depot, Eligard |
Alzheimer's Disease (Phase 2) | Tolmar Pharmaceuticals, Inc. | Other | Other | Advanced prostate cancer |
| Levetiracetam | Keppra | Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued) | UCB S.A. | Amyloid-Related, Other | Small Molecule | Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries |
| Levodopa | L-Dopa, Sinemet, Duodopa, Duopa, Inbrija, Parcopa, Prolopa, Rytary, Stalevo, Foslevodopa |
Parkinson's Disease (Approved) | AbbVie, Acorda Therapeutics, Inc., Amneal Pharmaceuticals, Inc. | Other Neurotransmitters | Small Molecule | |
| Linopirdine | DuP996 | Alzheimer's Disease (Discontinued) | Other | Small Molecule | None | |
| Liraglutide | Victoza™, Saxenda™ |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 2) | Novo Nordisk A/S | Other | Other | Diabetes, weight loss |
| Lomecel-B | mesenchymal stem cells | Alzheimer's Disease (Phase 2) | Longeveron | Inflammation, Other | Other | |
| Lornoxicam | Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) | JSW Lifesciences | Inflammation | Small Molecule | Pain in US | |
| Losartan | Cozaar®, MK0954 |
Alzheimer's Disease (Phase 2) | Merck | Other | Small Molecule | Hypertension, diabetic neuropathy |
| Lu AF20513 | Alzheimer's Disease (Discontinued) | Lundbeck, Otsuka Pharmaceutical Co., Ltd. | Amyloid-Related | Immunotherapy (active) | ||
| Lu AF87908 | Alzheimer's Disease (Phase 1) | Lundbeck | Tau | Immunotherapy (passive) | ||
| Lu AF88434 | Mild Cognitive Impairment (Discontinued) | Lundbeck | Other | Small Molecule | ||
| Lumateperone | ITI-007 | Alzheimer's Disease (Phase 3), Schizophrenia (Phase 3), Bipolar Disorder (Phase 3) | Bristol-Myers Squibb, Intra-Cellular Therapies, Inc. | Other Neurotransmitters | Small Molecule | |
| MEDI1341 | TAK-341 | Parkinson's Disease (Phase 1) | AstraZeneca, Takeda Pharmaceutical Company | alpha-synuclein | Immunotherapy (passive) | |
| MEDI1814 | Alzheimer's Disease (Phase 1) | AstraZeneca, Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | ||
| MEM 1003 | BAY Z 4406 | Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued), Vascular Dementia (Discontinued), Bipolar Disorder (Discontinued) | Memory Pharmaceuticals Corporation | Other | Small Molecule | None |
| MK-7622 | Alzheimer's Disease (Discontinued) | Merck | Unknown | Small Molecule | ||
| MKC-231 | Alzheimer's Disease (Inactive) | Mitsubishi Tanabe Pharma | Unknown | Small Molecule | None | |
| MSDC-0160 | Mitoglitazone | Alzheimer's Disease (Phase 2) | Metabolic Solutions Development Company | Other | Small Molecule | |
| MSK-DA01 | Parkinson's Disease (Phase 1) | Bayer, BlueRock Therapeutics | Other Neurotransmitters, Other | Other | ||
| MW150 | MW01-18-150SRM | Alzheimer's Disease (Phase 2) | Neurokine Therapeutics | Inflammation, Other | Small Molecule | |
| MW151 | MW01-2-151SRM, Minozac, MW01-2-151WH, compound 17 |
Alzheimer's Disease (Phase 1) | ImmunoChem Therapeutics, LLC | Inflammation | Small Molecule | |
| Masitinib | Masivet, Kinavet, AB1010, Masitinib mesylate |
Alzheimer's Disease (Phase 3), Amyotrophic Lateral Sclerosis (Phase 3) | AB Science | Other | Small Molecule | |
| Masupirdine | SUVN-502 | Alzheimer's Disease (Phase 2) | Suven Life Sciences Ltd | Other Neurotransmitters | Small Molecule | |
| Melatonin | Alzheimer's Disease (Phase 2) | Other | Supplement, Dietary | None | ||
| Memantine | Ebixa™, Namenda™ , Axura®, Akatinol®, Memary® |
Alzheimer's Disease (Approved) | Forest Laboratories, Inc., Lundbeck, Merz Pharma | Other Neurotransmitters | Small Molecule | Alzheimer's Disease |
| Metformin | Glucophage, Glucophage XR |
Alzheimer's Disease (Phase 2/3) | Other | Small Molecule | Type 2 Diabetes | |
| Methylphenidate | Ritalin, Concerta | Alzheimer's Disease (Phase 4) | Other Neurotransmitters | Small Molecule | Attention-deficit hyperactivity disorder (ADHD), narcolepsy | |
| Metrifonate | trichlorfon | Alzheimer's Disease (Discontinued) | Cholinergic System | Small Molecule | None | |
| Mevidalen | LY3154207, Mevidalen hydroxybenzoate |
Parkinson's Disease Dementia (Phase 2), Dementia with Lewy Bodies (Phase 2) | Eli Lilly & Co. | Other Neurotransmitters | Small Molecule | |
| Milameline | CI 979 | Alzheimer's Disease (Discontinued) | Aventis Pharmaceuticals, Inc. (was Hoechst) | Cholinergic System | Small Molecule | None |
| Minocycline | Solodyn, Arestin, Minocin, Dynacin |
Alzheimer's Disease (Discontinued) | Other | Small Molecule | ||
| Montelukast | Singulair, MK0476 | Alzheimer's Disease (Phase 2) | Intelgenx | Inflammation | Small Molecule | Asthma |
| Multivitamin-mineral Supplement | Centrum Silver | Mild Cognitive Impairment (Not Regulated) | Pfizer | Other | Supplement, Dietary | |
| NGX267 | AF267B | Alzheimer's Disease (Inactive) | TorreyPines Therapeutics, Inc. | Cholinergic System | Small Molecule | None |
| NIC5-15 | Pinitol, D-Pinitol |
Alzheimer's Disease (Phase 2) | Humanetics Pharmaceuticals Corporation | Amyloid-Related, Other | Small Molecule, Supplement, Dietary | |
| NPT520-34 | Amyotrophic Lateral Sclerosis (Phase 1), Parkinson's Disease (Phase 1) | Neuropore Therapies, Inc. | alpha-synuclein, Inflammation, Other | Small Molecule | ||
| NS2330 | Tesofensine | Alzheimer's Disease (Discontinued) | NeuroSearch A/S | Other Neurotransmitters | Small Molecule | |
| Nabilone | Cesamet | Alzheimer's Disease (Phase 3), Parkinson's Disease (Phase 2) | Bausch Health Companies Inc. | Other Neurotransmitters | Small Molecule | Nausea associated with cancer chemotherapy (US and other countries); pain spasticity in multiple sclerosis (Canada and other countries). |
| Naproxen | Aleve™, Anaprox™, Naprosyn™ |
Alzheimer's Disease (Discontinued) | Procter & Gamble | Inflammation | Small Molecule | Over-the-counter drug for reduction of pain, fever, inflammation, and stiffness. |
| Nasal Insulin | Detemir, Levemir, Humulin, Novolin, glulisine |
Alzheimer's Disease (Phase 2/3), Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 2) | Amyloid-Related, Other | Small Molecule, Other | Diabetes | |
| Nefiracetam | Alzheimer's Disease (Discontinued) | Daiichi Sankyo Pharmaceuticals | Cholinergic System | Small Molecule | None | |
| Neflamapimod | VX-745 | Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2), Huntington's Disease (Discontinued) | EIP Pharma, LLC | Inflammation | Small Molecule | |
| Nelonicline | ABT-126 | Alzheimer's Disease (Discontinued), Schizophrenia (Inactive) | AbbVie | Cholinergic System | Small Molecule | |
| Nelotanserin | APD-125 | Dementia with Lewy Bodies (Discontinued) | Axovant Sciences Ltd. | Other Neurotransmitters | Small Molecule | |
| NeoTrofin | AIT-082, leteprinim |
Alzheimer's Disease (Discontinued) | NeoTherapeutics, Inc. | Unknown | Small Molecule | None |
| Neramexane | MRZ 2/579 | Alzheimer's Disease (Discontinued) | Forest Laboratories, Inc., Merck | Other Neurotransmitters | Small Molecule | None |
| Nicotinamide Riboside | Niagen, NR, Nicotinamide, Vitamin B3 |
Alzheimer's Disease (Phase 1), Parkinson's Disease (Phase 2), Mild Cognitive Impairment (Phase 1/2) | ChromaDex, Others | Other | Supplement, Dietary | |
| Nilotinib | Tasigna, AMN107 |
Parkinson's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2), Alzheimer's Disease (Phase 3) | KeifeRx | Other | Small Molecule | Chronic myeloid leukemia |
| Nilvadipine | Nilvad, Nivadil, ARC029 |
Alzheimer's Disease (Inactive) | Archer Pharmaceuticals, Inc. | Other | Small Molecule | |
| Nimodipine | Nimotop | Frontotemporal Dementia (Discontinued) | Bayer | Metals | Small Molecule | Subarachnoid hemorrhage |
| Nuplazid | Pimavanserin, ACP-103, Pimavanserin tartrate |
Alzheimer's Disease (Rejected), Schizophrenia (Phase 3), Dementia (Rejected), Depression (Discontinued) | Acadia Pharmaceuticals | Other Neurotransmitters | Small Molecule | Parkinson's psychosis |
| ORM-12741 | Alzheimer's Disease (Phase 2) | Orion Pharma | Other Neurotransmitters | Small Molecule | ||
| Octagam®10% | Intravenous Immunoglobulin, NewGam |
Alzheimer's Disease (Inactive), Mild Cognitive Impairment (Inactive) | Octapharma | Amyloid-Related, Inflammation | Immunotherapy (passive) | Immunodeficiency disorders |
| PBFT02 | Frontotemporal Dementia (Phase 1/2) | Passage Bio | Other | DNA/RNA-based | ||
| PBT2 | PBT-2 | Alzheimer's Disease (Phase 2), Huntington's Disease (Phase 2) | Prana Biotechnology Limited | Amyloid-Related, Metals | Small Molecule | |
| PF-05212377 | PF-5212377, WYE-103760, SAM-760 |
Alzheimer's Disease (Discontinued) | Pfizer | Other Neurotransmitters | Small Molecule | |
| PF-06648671 | Alzheimer's Disease (Discontinued) | Pfizer | Amyloid-Related | Small Molecule | ||
| PF-06751979 | BACE inhibitor | Alzheimer's Disease (Discontinued) | Pfizer | Amyloid-Related | Small Molecule | |
| PF-06852231 | Alzheimer's Disease (Discontinued) | Pfizer | Cholinergic System | Small Molecule | ||
| PNT001 | Alzheimer's Disease (Phase 1), Traumatic Brain Injury (Phase 1) | Pinteon Therapeutics | Tau | Immunotherapy (passive) | ||
| PR001 | PR001A | Parkinson's Disease (Phase 1/2) | Eli Lilly & Co., Prevail Therapeutics | Other | DNA/RNA-based | |
| PR006 | Frontotemporal Dementia (Phase 1) | Eli Lilly & Co., Prevail Therapeutics | Other | DNA/RNA-based | ||
| PRX-03140 | Potassium salt | Alzheimer's Disease (Inactive) | Epix Pharmaceuticals | Other | Small Molecule | |
| PU-AD | PU-HZ151, icapamespib |
Alzheimer's Disease (Phase 2) | Samus Therapeutics | Other | Small Molecule | |
| PXT864 | PXT00864 | Alzheimer's Disease (Phase 2) | Pharnext | Other Neurotransmitters | Combination, Small Molecule | |
| Pepinemab | VX15, VX15/2503 |
Alzheimer's Disease (Phase 1/2), Huntington's Disease (Phase 2) | Vaccinex, Inc. | Inflammation | Immunotherapy (passive) | |
| Phenserine | Alzheimer's Disease (Inactive) | Annovis Bio, TorreyPines Therapeutics, Inc. | Cholinergic System | Small Molecule | ||
| Physostigmine Salicylate | Synapton | Alzheimer's Disease (Discontinued) | Forest Laboratories, Inc. | Cholinergic System | Small Molecule | |
| Pioglitazone | AD4833, Actos®, Glustin™, Piozone® |
Mild Cognitive Impairment (Phase 3) | Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. | Inflammation, Other | Small Molecule | Type 2 diabetes mellitus |
| Piromelatine | Neu-P11 | Alzheimer's Disease (Phase 2) | Neurim Pharmaceuticals Ltd. | Other Neurotransmitters, Other | Small Molecule | |
| Ponezumab | PF-04360365 | Alzheimer's Disease (Discontinued), Cerebral Amyloid Angiopathy (Discontinued) | Pfizer | Amyloid-Related | Immunotherapy (passive) | None |
| Posiphen | ANVS-401, Posiphen tartrate |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 1/2) | Annovis Bio | Amyloid-Related, alpha-synuclein | Small Molecule | |
| Prasinezumab | PRX002, RO7046015, RG7935, NEOD002 | Parkinson's Disease (Phase 2) | Hoffmann-La Roche, Prothena | alpha-synuclein | Immunotherapy (passive) | |
| Prazosin | Prazosin hydrochloride, Minipress, Hypovase, Vasoflex |
Alzheimer's Disease (Phase 4) | Other Neurotransmitters | Small Molecule | Hypertension | |
| Prednisone | Alzheimer's Disease (Discontinued) | Inflammation | Small Molecule | |||
| Pridopidine | ACR16, TV-7820, Huntexil, ASP2314 |
Amyotrophic Lateral Sclerosis (Phase 2/3), Huntington's Disease (Phase 3), Parkinson's Disease (Inactive) | Prilenia Therapeutics | Other | Small Molecule | |
| Propentofylline | HWA 285, PPF |
Alzheimer's Disease (Discontinued) | Unknown | Small Molecule | ||
| Protollin | Alzheimer's Disease (Phase 1) | I-MAB Biopharma Co., Ltd., Jiangsu Nhwa Pharmaceutical Co., Ltd | Inflammation | Immunotherapy (active) | ||
| RG3487 | RO5313534, MEM 3454 |
Alzheimer's Disease (Inactive) | Roche | Cholinergic System | Small Molecule | |
| RG7129 | RO5508887, BACE Inhibitor |
Alzheimer's Disease (Discontinued) | Roche | Amyloid-Related | Small Molecule | |
| RG7345 | RO6926496 | Alzheimer's Disease (Discontinued) | Tau | Immunotherapy (passive) | ||
| RO7126209 | RG6102, Brain shuttle gantenerumab |
Alzheimer's Disease (Phase 1) | Hoffmann-La Roche | Amyloid-Related | Immunotherapy (passive) | |
| Rasagiline | Rasagiline mesylate, Azilect, TVP-1012 |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Approved), Amyotrophic Lateral Sclerosis (Inactive) | Teva | Other Neurotransmitters | Small Molecule | |
| Rember TM | Methylene Blue , methylthioninium (MT), TRx-0014, Tau aggregation inhibitor (TAI) |
Alzheimer's Disease (Discontinued) | TauRx Therapeutics Ltd | Tau | Small Molecule | Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia. |
| Repetitive Transcranial Magnetic Stimulation | rTMS | Alzheimer's Disease (Phase 2) | Neuronix Ltd | Other | Procedural Intervention | |
| Resveratrol | trans-3,4',5-trihydroxystilbene | Alzheimer's Disease (Phase 3), Mild Cognitive Impairment (Phase 4) | Other | Small Molecule, Supplement, Dietary | ||
| Rilapladib | SB-659032 | Alzheimer's Disease (Phase 2) | GlaxoSmithKline (GSK) | Other | Small Molecule | |
| Riluzole | Rilutek®, RP 54274 |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) | Sanofi | Other Neurotransmitters, Other | Small Molecule | Amyotrophic Lateral Sclerosis in many countries |
| Rivastigmine | Exelon™, Rivastigmine tartrate , Rivastach® Patch, Prometax®, SDZ ENA 713 |
Alzheimer's Disease (Approved), Parkinson's Disease Dementia (Approved) | Novartis Pharmaceuticals Corporation | Cholinergic System | Small Molecule | Mild to moderate Alzheimer’s disease and mild to moderate dementia related to Parkinson's disease |
| Rofecoxib | Vioxx™ | Alzheimer's Disease (Discontinued) | Merck | Inflammation | Small Molecule | Withdrawn from market |
| Rosiglitazone | Rosiglitazone maleate, Avandia |
Alzheimer's Disease (Discontinued) | GlaxoSmithKline (GSK) | Other | Small Molecule | |
| Rotigotine | Neupro | Alzheimer's Disease (Phase 2) | UCB S.A. | Other Neurotransmitters | Small Molecule | Parkinson's disease, Restless Leg Syndrome |
| S 38093 | Alzheimer's Disease (Discontinued) | Servier | Cholinergic System, Other Neurotransmitters | Small Molecule | ||
| S-Equol | Aus-131 | Alzheimer's Disease (Phase 1) | Ausio Pharmaceuticals, LLC | Other | Small Molecule | |
| S47445 | CX1632 | Alzheimer's Disease (Discontinued) | Cortex Pharmaceuticals, Inc., Servier | Other Neurotransmitters | Small Molecule | |
| SAGE-718 | Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 2), Huntington's Disease (Phase 2) | Sage Therapeutics, Inc. | Other Neurotransmitters | Small Molecule | ||
| SAR110894D | Alzheimer's Disease (Phase 2) | Sanofi | Other | Small Molecule | ||
| SAR228810 | Alzheimer's Disease (Discontinued) | Sanofi | Amyloid-Related | Immunotherapy (passive) | ||
| SB 202026 | Memric | Alzheimer's Disease (Discontinued) | Other Neurotransmitters | Small Molecule | ||
| SDI-118 | Alzheimer's Disease (Phase 1), Mild Cognitive Impairment (Phase 1) | AbbVie | Other | Small Molecule | ||
| SGS-742 | CGP-36742, DVD-742 |
Alzheimer's Disease (Discontinued) | Novartis Pharmaceuticals Corporation, Saegis Pharmaceuticals, Inc. | Other Neurotransmitters | Small Molecule | |
| ST101 | ZSET1446 | Alzheimer's Disease (Inactive) | Sonexa Therapeutics, Inc. | Unknown | Small Molecule | |
| SUVN-G3031 | Alzheimer's Disease (Phase 1) | Suven Life Sciences Ltd | Cholinergic System, Other Neurotransmitters | Small Molecule | ||
| Sabeluzole | R58735 | Alzheimer's Disease (Inactive) | Unknown | Small Molecule | ||
| Safinamide | Xadago, Onstryv |
Multiple System Atrophy (Phase 2), Parkinson's Disease (Approved) | Newron, Zambon Company S.p.A. | Other Neurotransmitters | Small Molecule | |
| Saracatinib | AZD0530 | Alzheimer's Disease (Discontinued), Parkinson's Disease (Phase 1) | AstraZeneca | Other | Small Molecule | |
| Sargramostim | GM-CSF Leukine , Leukine® |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 1) | Genzyme, Partner Therapeutics, Inc., Sanofi | Inflammation, Other, Unknown | Other | Bone Marrow Stimulation |
| Semagacestat | LY450139 Dihydrate , hydroxylvaleryl monobenzocaprolactam |
Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Small Molecule | None |
| Semaglutide | Ozempic, Rybelsus |
Alzheimer's Disease (Phase 3), Parkinson's Disease (Phase 2) | Novo Nordisk A/S | Other | Other | Type 2 Diabetes |
| Sembragiline | RO4602522, RG1577 |
Alzheimer's Disease (Discontinued) | Evotech AG | Other Neurotransmitters, Other | Small Molecule | |
| Semorinemab | RO7105705 , MTAU9937A, RG6100 |
Alzheimer's Disease (Phase 2) | AC Immune SA, Genentech, Hoffmann-La Roche | Tau | Immunotherapy (passive) | |
| Simufilam | PTI-125, sumifilam |
Alzheimer's Disease (Phase 3) | Cassava Sciences | Amyloid-Related | Small Molecule | |
| Simvastatin | Zocor®, Lipex®, Lipovas®, Denan® |
Alzheimer's Disease (Inactive), Mild Cognitive Impairment (Phase 4) | Merck | Cholesterol | Small Molecule | Hypercholesterolemia and diabetic cardiomyopathy. |
| Solanezumab | LY2062430 | Alzheimer's Disease (Phase 3) | Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | None |
| Souvenaid | Fortasyn Connect | Alzheimer's Disease (Not Regulated) | Nutricia | Other | Supplement, Dietary | |
| Suritozole | MD 26479 | Alzheimer's Disease (Discontinued) | Aventis Pharmaceuticals, Inc. (was Hoechst) | Other Neurotransmitters | Small Molecule | |
| Suvorexant | Belsomra, MK-4305 |
Alzheimer's Disease (Approved) | Merck | Other | Small Molecule | Insomnia, Insomnia in mild to moderate Alzheimer's disease |
| T3D-959 | DB959 | Alzheimer's Disease (Phase 2) | T3D Therapeutics, Inc. | Other | Small Molecule | |
| TB006 | Alzheimer's Disease (Phase 1) | TrueBinding, Inc. | Inflammation | Immunotherapy (passive) | ||
| TPI 287 | Alzheimer's Disease (Inactive), Corticobasal Degeneration (Inactive), Progressive Supranuclear Palsy (Phase 1) | Cortice Biosciences | Tau | Small Molecule | ||
| TPN-101 | OBP-601, BMS-986001, censavudine, festinavir, 4'-ethynyl stavudine, 4'-ethynyl-d4T |
ALS-FTD (Phase 2), Progressive Supranuclear Palsy (Phase 2) | Transposon Therapeutics | Inflammation | Small Molecule, DNA/RNA-based | |
| Tacrine | Cognex™ | Alzheimer's Disease (Approved) | Pfizer, Shionogi Pharma | Cholinergic System | Small Molecule | |
| Telmisartan | Micardis | Alzheimer's Disease (Phase 2) | Boehringer Ingelheim | Other | Small Molecule | Hypertension |
| Thalidomide | Thalomid® | Alzheimer's Disease (Discontinued) | Celgene Corporation | Amyloid-Related, Inflammation | Small Molecule | |
| Tideglusib | NP031112, Nypta® , Zentylor™ , Glycogen synthase kinase 3 inhibitor, NP12 |
Alzheimer's Disease (Discontinued), Progressive Supranuclear Palsy (Discontinued) | Zeltia Group | Tau | Small Molecule | |
| Tilavonemab | ABBV-8E12, C2N 8E12, HJ8.5 |
Progressive Supranuclear Palsy (Discontinued), Alzheimer's Disease (Discontinued) | AbbVie, C2N Diagnostics, LLC | Tau | Immunotherapy (passive) | |
| Tofersen | BIIB067, Ionis-SOD1Rx, ASO1 |
Amyotrophic Lateral Sclerosis (Phase 3) | Biogen, IONIS Pharmaceuticals | Other | DNA/RNA-based | |
| Trazodone | Trazodone hydrochloride, Oleptro, Desyrel |
Alzheimer's Disease (Phase 3), Mild Cognitive Impairment (Phase 3), Amyotrophic Lateral Sclerosis (Phase 2/3) | Other Neurotransmitters | Small Molecule | Depression | |
| Tricaprilin | AC-1204 , Caprylic triglyceride |
Alzheimer's Disease (Phase 2/3) | Cerecin Pte. Ltd. | Other | Supplement, Dietary, Other | None |
| Troriluzole | BHV-4157, trigriluzole, FC-4157 | Alzheimer's Disease (Discontinued) | Biohaven Pharmaceuticals | Other Neurotransmitters | Other | |
| UB-311 | Alzheimer's Disease (Phase 3) | United Neuroscience | Amyloid-Related | Immunotherapy (active) | ||
| UCB0599 | NPT200-11 | Parkinson's Disease (Phase 2) | Neuropore Therapies, Inc., Novartis Pharmaceuticals Corporation, UCB S.A. | alpha-synuclein | Small Molecule | |
| UCB7853 | Parkinson's Disease (Phase 1) | UCB S.A. | alpha-synuclein | Immunotherapy (passive) | ||
| Umibecestat | CNP520, BACE Inhibitor |
Alzheimer's Disease (Discontinued) | Amgen, Inc., Novartis Pharmaceuticals Corporation | Amyloid-Related | Small Molecule | |
| VY-AADC | VY-AADC01, VY-AADC02 |
Parkinson's Disease (Discontinued) | Neurocrine Biosciences, Voyager Therapeutics | Other Neurotransmitters | DNA/RNA-based | |
| Vafidemstat | ORY-2001 | Alzheimer's Disease (Phase 2) | Oryzon Corporate | Other Neurotransmitters | Small Molecule | |
| Valacyclovir | Valtrex, Valaciclovir, 256U87 |
Alzheimer's Disease (Phase 2) | GlaxoSmithKline (GSK) | Other | Small Molecule | Herpes virus outbreaks |
| Valproate | Depakote, Depakene, Valproic acid , Divalproex sodium |
Alzheimer's Disease (Inactive) | Abbott Laboratories | Other Neurotransmitters | Small Molecule | Epilepsy, Bipolar disorder, Migraine |
| Vanutide cridificar | ACC-001, PF-05236806 |
Alzheimer's Disease (Discontinued) | Janssen | Amyloid-Related | Immunotherapy (active) | None |
| Varenicline | Champix™, Chantix™, Varenicline tartrate, CP-526,555, Alpha4 beta2 nicotinic receptor agonist |
Alzheimer's Disease (Discontinued) | Pfizer | Cholinergic System | Small Molecule | Smoking cessation |
| Varoglutamstat | PQ912 | Alzheimer's Disease (Phase 2) | Probiodrug AG, Vivoryon Therapeutics N.V. | Amyloid-Related, Inflammation | Small Molecule | |
| Vascepa | Icosapent ethyl (IPE), Ethyl eicosapentaenoic acid (E-EPA), AMR101, Miraxion |
Alzheimer's Disease (Phase 2/3) | Other | Small Molecule | Severe hypertriglyceridemia, and to lower risk of cardiovascular events in people with elevated triglycerides | |
| Venglustat | Ibiglustat, GZ/SAR402671, Genz-682452 |
Parkinson's Disease (Inactive) | Genzyme, Sanofi | alpha-synuclein, Other | Small Molecule | |
| Verdiperstat | AZD3241, BHV-3241 |
Motor Neuron Disease (Phase 2/3), Multiple System Atrophy (Discontinued) | AstraZeneca, Biohaven Pharmaceuticals | Inflammation, Other | Small Molecule | |
| Verubecestat | MK-8931, MK-8931-009 , BACE inhibitor |
Alzheimer's Disease (Discontinued) | Merck | Amyloid-Related | Small Molecule | |
| Vodobatinib | K0706, SCC-138, SCO-088 |
Parkinson's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2) | Sun Pharma Advanced Research Company Ltd. | Other | Small Molecule | |
| WVE-004 | Frontotemporal Dementia (Phase 1/2), Amyotrophic Lateral Sclerosis (Phase 1/2) | Wave Life Sciences USA, Inc. | Other | DNA/RNA-based | ||
| XPro1595 | Pegipanermin, INB03, NeuLiv, XENP1595, DN-TNF, XENP345, XPro™ , LIVNate |
Alzheimer's Disease (Phase 2), Mild Cognitive Impairment (Phase 2) | INmune Bio Inc. | Inflammation | Other | |
| Xaliproden | SR 57746A | Alzheimer's Disease (Discontinued) | Sanofi | Other Neurotransmitters, Other | Small Molecule | |
| Xanamem | UE 2343 | Alzheimer's Disease (Phase 2) | Actinogen Medical | Other | Small Molecule | |
| YTX-7739 | Parkinson's Disease (Phase 1) | Yumanity Therapeutics | Other | Small Molecule | ||
| Young Plasma | Progressive Supranuclear Palsy (Inactive), Alzheimer's Disease (Inactive) | Alkahest, Inc., Grifols Biologicals Inc. | Inflammation, Other, Unknown | Other | ||
| Zagotenemab | LY3303560 | Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Tau, Unknown | Immunotherapy (passive) | |
| kMCT-ONS | medium chain triglyceride-based ketogenic oral nutritional supplement, kMCT | Alzheimer's Disease (Not Regulated) | Nestlé Health Science | Other | Supplement, Dietary |