Therapeutics

AL003

Overview

Name: AL003
Therapy Type: Immunotherapy (active) (timeline)
Target Type: Inflammation (timeline)
Condition(s): Alzheimer's Disease
U.S. FDA Status: Alzheimer's Disease (Phase 1)
Company: AbbVie, Alector

Background

AL003 is a monoclonal antibody being co-developed by Alector and Abbvie. According to Alector, it counteracts the function of Siglec-3, a microglial transmembrane receptor that reportedly interacts with TREM2 (Oct 2015 news). The gene encoding Siglec-3, CD33, has been associated with AD risk via a protective variant, expression levels, and alternative splicing (Estus et al., 2019Katsumata et al., 2019Bertram et al., 2008).

Findings

In March 2019, AL003 entered the clinic with a 52-person trial being run in Melbourne, Australia (May 2019 conference news). In a single-ascending-dose phase, 42 healthy participants receive infusions of one of seven escalating doses or placebo; in a subsequent multiple-ascending-dose phase, 10 participants with AD will receive drug, two placebo. Outcomes include safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity. The trial is projected to finish in July 2020.

For all trials of AL003, see clinicaltrials.gov.

Last Updated: 11 Jun 2019

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References

News Citations

  1. Antibodies Against Microglial Receptors TREM2 and CD33 Head to Trials
  2. Alzheimer’s Risk Genes Interact in Immune Cells

Paper Citations

  1. . Evaluation of CD33 as a genetic risk factor for Alzheimer's disease. Acta Neuropathol. 2019 Aug;138(2):187-199. Epub 2019 Apr 4 PubMed.
  2. . Translating Alzheimer's disease-associated polymorphisms into functional candidates: a survey of IGAP genes and SNPs. Neurobiol Aging. 2019 Feb;74:135-146. Epub 2018 Oct 23 PubMed.
  3. . Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet. 2008 Nov;83(5):623-32. PubMed.

External Citations

  1. clinicaltrials.gov

Further Reading

No Available Further Reading