Brosseron F, Traschütz A, Widmann CN, Kummer MP, Tacik P, Santarelli F, Jessen F, Heneka MT. Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer's disease. Alzheimers Res Ther. 2018 Feb 26;10(1):25. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
MCP-1
(CSF)		 AD
(116)		 342 ± 96
pg/mL		 Electrochemiluminescence;
V-PLEX Human Biomarker 40-Plex Kit;
Meso Scale Discovery		 McKhann et al., 2011
MCP-1
(CSF)		 CTRL-
Other Controls
(85)		 323 ± 112
pg/mL		 Electrochemiluminescence;
V-PLEX Human Biomarker 40-Plex Kit;
Meso Scale Discovery
MCP-1
(CSF)		 FTD
(20)		 336 ± 112
pg/mL		 Electrochemiluminescence;
V-PLEX Human Biomarker 40-Plex Kit;
Meso Scale Discovery		 Gorno-Tempini et al., 2011
MCP-1
(CSF)		 PD
(16)		 335 ± 73
pg/mL		 Electrochemiluminescence;
V-PLEX Human Biomarker 40-Plex Kit;
Meso Scale Discovery		 Hughes et al., 1992
sTREM2
(CSF)		 AD
(116)		 4315 ± 2235
pg/mL		 Electrochemiluminescence;
Other/Not Specified;
In-house		 McKhann et al., 2011
sTREM2
(CSF)		 CTRL-
Other Controls
(85)		 2994 ± 2269
pg/mL		 Electrochemiluminescence;
Other/Not Specified;
In-house
sTREM2
(CSF)		 DLB
(11)		 4222 ± 1675
pg/mL		 Electrochemiluminescence;
Other/Not Specified;
In-house
sTREM2
(CSF)		 FTD
(20)		 3343 ± 2031
pg/mL		 Electrochemiluminescence;
Other/Not Specified;
In-house		 Gorno-Tempini et al., 2011
sTREM2
(CSF)		 PD
(16)		 4186 ± 2243
pg/mL		 Electrochemiluminescence;
Other/Not Specified;
In-house		 Hughes et al., 1992

Recommends

Please login to recommend the paper.

Comments

No Available Comments

Make a Comment

To make a comment you must login or register.

This paper appears in the following:

AlzBiomarker

  1. AD vs CTRL : MCP-1 (CSF)
  2. CTRL vs AD : MCP-1 (CSF)
  3. FTD vs AD : MCP-1 (CSF)
  4. PD vs AD : MCP-1 (CSF)
  5. AD vs CTRL : sTREM2 (CSF)
  6. CTRL vs AD : sTREM2 (CSF)
  7. DLB vs AD : sTREM2 (CSF)
  8. FTD vs AD : sTREM2 (CSF)
  9. PD vs AD : sTREM2 (CSF)