PAPER Abdel-Magid AF

LRRK2 Kinase Inhibitors as Possible Therapy for Parkinson's Disease and Other Neurodegenerative Disorders.

ACS Med Chem Lett. 2019 Jun 13;10(6):846-847. Epub 2019 May 24 PubMed: 31223436

PAPER Csoti I, Herbst H, Urban P, Woitalla D, Wüllner U

Polypharmacy in Parkinson's disease: risks and benefits with little evidence.

J Neural Transm (Vienna). 2019 Jul;126(7):871-878. Epub 2019 Jun 20 PubMed: 31222606

PAPER Sexton CE, Sykara K, Karageorgiou E, Zitser J, Rosa T, Yaffe K, Leng Y

Connections Between Insomnia and Cognitive Aging.

Neurosci Bull. 2019 Jun 20; PubMed: 31222500

PAPER Nuzzo T, Punzo D, Devoto P, Rosini E, Paciotti S, Sacchi S, Li Q, Thiolat ML, Véga C, Carella M, Carta M, Gardoni F, Calabresi P, Pollegioni L, Bezard E, Parnetti L, Errico F, Usiello A

The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson's disease patients.

Sci Rep. 2019 Jun 20;9(1):8898. PubMed: 31222058

PAPER Avenali M, Toffoli M, Mullin S, McNeil A, Hughes DA, Mehta A, Blandini F, Schapira AH

Evolution of prodromal parkinsonian features in a cohort of GBA mutation-positive individuals: a 6-year longitudinal study.

J Neurol Neurosurg Psychiatry. 2019 Oct;90(10):1091-1097. Epub 2019 Jun 20 PubMed: 31221723

PAPER Ustyantseva EI, Medvedev SP, Vetchinova AS, Minina JM, Illarioshkin SN, Zakian SM

A Platform for Studying Neurodegeneration Mechanisms Using Genetically Encoded Biosensors.

Biochemistry (Mosc). 2019 Mar;84(3):299-309. PubMed: 31221068

PAPER Kastanenka KV, Calvo-Rodriguez M, Hou SS, Zhou H, Takeda S, Arbel-Ornath M, Lariviere A, Lee YF, Kim A, Hawkes JM, Logan R, Feng D, Chen X, Gomperts SN, Bacskai BJ

Frequency-dependent exacerbation of Alzheimer's disease neuropathophysiology.

Sci Rep. 2019 Jun 20;9(1):8964. PubMed: 31221985

Alberto Lleó on NfL: Useful in Differential Diagnosis?

COMMENT I found this study particularly interesting because NfL in CSF (and probably in plasma) may be incorporated soon in clinical routine to the current biomarker panel. The strength of NfL is that, since it is only expressed in the nervous system, it can capt

NfL: Useful in Differential Diagnosis?

RESEARCH NEWS 2019-06-22 Research News In a comprehensive meta-analysis, scientists led by Claire Bridel, VU University Medical Center, Amsterdam, compared levels of neurofilament light in the cerebrospinal fluid of healthy controls and patients covering a spectrum of neurologica

Matthew Ayers

Aβ Acts Through Pericytes to Throttle Brain Blood Flow

RESEARCH NEWS 2019-06-22 Research News In Alzheimer’s disease, blood flows sluggishly through the brain, partly because Aβ provokes small blood vessels to constrict. In the June 20 Science, researchers led by David Attwell at University College London blame this on pericytes, tin

Costantino Iadecola on Aβ Acts Through Pericytes to Throttle Brain Blood Flow

COMMENT The story of the vascular effects of Aβ is evolving steadily, and the present paper, in conjunction with the paper of Cruz Hernández et al., 2019, represents the latest chapters. It has been known for a while that Aβ is a vasoconstrictor acting through fr