6 RESULTS
COMMENT It’s been almost a decade since the exciting initial discovery of tau SUMOylation by SUMO1, which inhibits degradation of tau and promotes its accumulation. However, it is unknown whether other SUMO isoforms have a similar role. Perhaps surprisingly, thes
COMMENT The authors performed incredibly thorough analyses of synaptic structure in postmortem human brain which enabled, for the first time, a very detailed look into the interactions among synapses, astrocytes, and microglia as they relate to cognitive decline.
COMMENT This is a comprehensive and remarkable investigation into the potential interdependency of different tau phosphorylation sites. With these data, new sets of questions pop up: What is the mechanism and, importantly, the role of tau phosphatases? What are t
COMMENT This is a wonderfully comprehensive analysis of interactions between neuronal proteins and tau. We’ve known for a long time that tau is distributed among many different compartments in neurons, but there’s still a lot that’s unknown about how this process
COMMENT This work elegantly addresses an important question: Does tau spread through synaptically connected brain regions as Alzheimer's disease progresses? By using detailed functional connectivity maps and, importantly, two independent cohorts of individua
COMMENT This paper is really interesting – antibodies directed against tau reduced tau pathology in mice expressing a mutant, aggregating form of human tau. The antibody appears to both prevent the formation of extracellular tau aggregates as well as sequester pa
