Tondelli M, Bedin R, Chiari A, Molinari MA, Bonifacio G, Lelli N, Trenti T, Nichelli P. Role of cerebrospinal fluid biomarkers to predict conversion to dementia in patients with mild cognitive impairment: a clinical cohort study. Clin Chem Lab Med. 2015 Feb 1;53(3):453-60. PubMed.
AlzBiomarker Database
Meta-Analysis
- MCI-AD vs MCI-Stable : Aβ42 (CSF)
- MCI-AD vs MCI-Stable : tau-p181 (CSF)
- MCI-AD vs MCI-Stable : tau-total (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| Aβ42 (CSF) |
MCI-AD (31) |
442.4 ± 114.6 pg/mL |
ELISA; Other/Not Specified; Innogenetics |
McKhann et al., 1984 |
| Aβ42 (CSF) |
MCI-Stable (23) |
869.9 ± 335.4 pg/mL |
ELISA; Other/Not Specified; Innogenetics |
Petersen et al., 1999 |
| tau-p181 (CSF) |
MCI-AD (31) |
101.4 ± 61.5 pg/mL |
ELISA; Other/Not Specified; Innogenetics |
McKhann et al., 1984 |
| tau-p181 (CSF) |
MCI-Stable (23) |
59.6 ± 24.3 pg/mL |
ELISA; Other/Not Specified; Innogenetics |
Petersen et al., 1999 |
| tau-total (CSF) |
MCI-AD (31) |
466.5 ± 292.4 pg/mL |
ELISA; Other/Not Specified; Innogenetics |
McKhann et al., 1984 |
| tau-total (CSF) |
MCI-Stable (23) |
361.6 ± 357.3 pg/mL |
ELISA; Other/Not Specified; Innogenetics |
Petersen et al., 1999 |
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