Postdoctoral Fellow


Alzheimer's Clinical & Translational Research Unit (ACTRU) and Massachusetts Alzheimer’s Disease Research Center (MADRC)


Charlestown, Massachusetts

Principal Investigator

Steven Arnold

Principal Investigator

Becky Carlyle



The Alzheimer's Clinical & Translational Research Unit (ACTRU) and Massachusetts Alzheimer’s Disease Research Center (MADRC) seek to hire a highly motivated and organized self-starter to work with its rapidly expanding biomarkers operation. This role will be to develop novel, mechanism-associated protein biomarkers for use in innovative clinical trials. Work will focus on biofluid and brain tissue biomarkers, including the development of novel methods for quantifying endogeneous peptide proteoforms, tissue fractionation protocols, and developing mass-spectrometry methods, both targeted and non-targeted, for robust and high-throughput biomarker quantification in collaboration with mass-spectrometry core facilities. Work will be performed under the supervision of the co-director of the MADRC Biomarker Core and the director of the Alzheimer’s Clinical & Translational Research unit. Applications for this position are encouraged from under-represented minorities.


Incumbent will have a desk and bench in the laboratory in Building 114 in the Charlestown Navy Yard that is equipped with a networked computer. Incumbent will spend some time in the Mass-Spectrometry Facility in Building 149 in the Charlestown Navy Yard.

Primary Location: USA-MA-Charlestown Work Locations: 114 16th Street, Charlestown 02129

Secondary Location: USA-MA-Charlestown Work Locations: 149 13th Street, Charlestown 02129

EEO Statement

Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, it chooses to lead.

Applications from protected veterans and individuals with disabilities are strongly encouraged.



Biofluid sample preparation, including the development of new and high-throughput methods for rapid and accurate quantification of mechanism-associated biomarkers and endogenously cleaved neuropeptides.

The development of methods for analysis of cellular compartmentalization in frozen human brain tissue and iPSC cell lines, for accurate quantification of mechanism-associated biomarkers.

Development of mass-spectrometry methods for both targeted and untargeted assessment of biofluids, brain tissue, and iPSCs derived from individuals with Alzheimer’s disease and related dementias.

In collaboration with the ACTRU data analysis team, perform assessment of data quality control metrics, analyze data and perform statistical testing, and prepare reports and figures for publication.

Present data through publication of manuscripts and attendance at national and international conferences.

Participate in weekly lab meetings and present data.

All other duties, as assigned.


Must be highly organized, detail-oriented, and have a strong motivation to learn. Strong technical expertise in biochemistry or molecular/cell biology. Experience with mass spectrometry-based proteomics. Experience with protein purification techniques is preferred (LC, MS sample prep for example). Experience with analyzing large datasets is preferred. Must have excellent interpersonal, speaking, and writing abilities. Ability to work both independently and collaboratively as a member of a team. On own initiative, ability to identify potential problems and troubleshoot problems as necessary. Must be able to prioritize and perform multiple tasks independently.


Ph.D. in cell biology, biochemistry, chemistry, systems biology or a related field is required.

Equivalent Experience –– please document if educational requirements can be met through equivalent experience. Candidates who can demonstrate equivalent experience to a Ph.D. through work in a Proteomics Core, for example, will be considered.


Required: Ph.D. training or three-plus years of relevant work in a mass-spectrometry facility.


Will assist PI with ordering using the electronic ordering system. Will record spending to assist in monitoring budgets.