Alexxis Kennedy
Okemah, United States
SEARCH RESULTS
331743 RESULTS
Jennifer Rauch on Might SORL1 Bind Tau in Glia, Fuel Its Aggregation?
COMMENT This is an interesting mechanistic study by Cooper et al., looking at the interactions between tau and SORL1, a protein with known associations to AD. This new study expands on the authors’ prior biochemical work looking at the tau-LRP1 interaction and it
Sam Gandy on Might SORL1 Bind Tau in Glia, Fuel Its Aggregation?
COMMENT SORL1 is best known as a modulator of APP sorting, metabolism, and amyloidogenesis. This new data extends the action of SORL1 to tauopathy, providing an unexpected convergence of two key pathways in Alzheimer pathogenesis. Tau aggregates form in neurons a
Might SORL1 Bind Tau in Glia, Fuel Its Aggregation?
RESEARCH NEWS 2024-05-04 Research News Over the last few decades, evidence has emerged to peg the sortilin-related receptor, SORL1, as a risk factor for Alzheimer’s disease and even as the fourth gene for familial AD. SORL1 helps traffic amyloid precursor protein through the endo
Marc Diamond on Might SORL1 Bind Tau in Glia, Fuel Its Aggregation?
COMMENT The take-home message for me is that any assertion of a single protein “receptor” for tau at the surface should be taken with a grain of salt. This paper purports to show that SORL1 is a “receptor” for tau. However, one of the final figures indicates that
Gregory Petsko on Might SORL1 Bind Tau in Glia, Fuel Its Aggregation?
COMMENT The paper is interesting and potentially important. That retromer-regulated trafficking is important in tauopathies, including Alzheimer’s disease, is well-established (e.g., Mishra et al., 2023). However, the direct binding of tau to SORL1 is a new findi
Kenneth Kosik on Might SORL1 Bind Tau in Glia, Fuel Its Aggregation?
COMMENT This paper by J.M. Cooper et al. is a well-executed study that advances our thinking about the route tau travels once internalized. In essence, the problem we face is that, internalized via LRP1 through which it enters endosomes, tau must escape the endos
George King
Atlanta, United States
PAPER Jacobsen L, Madsen P, Jacobsen C, Nielsen MS, Gliemann J, Petersen CM
Activation and functional characterization of the mosaic receptor SorLA/LR11.
J Biol Chem. 2001 Jun 22;276(25):22788-96. Epub 2001 Apr 9 PubMed: 11294867Sooyeon Jeon
Department of Intelligent Precision Healthcare ConvergenceSuwon, Korea, Republic of
Peter Benson
Notice of Special Interest (NOSI): Promoting Data Reuse for Health Research (NOT-OD-24-096)
GRANT Friday, May 3, 2024- 3:45pm National Institutes of Health This Notice of Special Interest (NOSI) solicits competitive revision applications. Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/notice-files/NOT-OD-24-096.html 04 Nov 2
Lasker Clinical Research Scholars Program (Si2/R00 Clinical Trial Optional) (PAR-24-202)
GRANT Friday, May 3, 2024- 3:45pm National Institutes of Health August 30, 2024. https://grants.nih.gov/grants/guide/pa-files/PAR-24-202.html 31 Aug 2024
Notice of Information: Technical Assistance Webinars for PAR-24-206: Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN) (U54 Clinical Trial Optional) (NOT-TR-24-024)
GRANT Friday, May 3, 2024- 3:30pm National Center for Advancing Translational Sciences Two identical technical assistance webinars will be conducted. 1) May 22, 2024 – 9:00 am to 10:30 am Eastern Time. 2) June 3, 2024 – 3:00 pm to 4:30 pm Eastern Time. https://
PAPER Goldberg A, Xie B, Shi L
The Molecular Mechanism of Positive Allosteric Modulation at the Dopamine D1 Receptor.
Int J Mol Sci. 2023 Aug 16;24(16) PubMed: 37629030Current Filters
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