PAPER Liu Y, Xia X, Zheng M, Shi B
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PAPER Sanjay, Sood R, Jaiswal V, Kang SU, Park M, Lee HJ
Nobiletin regulates intracellular Ca2+ levels via IP3R and ameliorates neuroinflammation in Aβ42-induced astrocytes.
Redox Biol. 2024 May 16;73:103197. PubMed.PAPER Li H, Fan X, Li K, Zhang C, Jia X
Increased anterior insula connectivity associated with cognitive maintenance in amnestic mild cognitive impairment: a longitudinal study.
Brain Imaging Behav. 2024 May 24; PubMed.PAPER Panigrahi P, Das S, Chakrabarti S
CCADD: An online webserver for Alzheimer's disease detection from brain MRI.
Comput Biol Med. 2024 May 15;177:108622. PubMed.PAPER Laczó M, Svatkova R, Lerch O, Martinkovic L, Zuntychova T, Nedelska Z, Horakova H, Vyhnalek M, Hort J, Laczó J
Spatial navigation questionnaires as a supportive diagnostic tool in early Alzheimer's disease.
iScience. 2024 Jun 21;27(6):109832. Epub 2024 Apr 26 PubMed.PAPER Abukuri DN
Novel Biomarkers for Alzheimer's Disease: Plasma Neurofilament Light and Cerebrospinal Fluid.
Int J Alzheimers Dis. 2024;2024:6668159. Epub 2024 May 15 PubMed.PAPER Yoon CH, Groff C, Criss O
Lecanemab: A Second in Class Therapy for the Management of Early Alzheimer's Disease.
Innov Pharm. 2024;15(1) Epub 2024 Mar 18 PubMed.PAPER Yaghmaei E, Lu H, Ehwerhemuepha L, Zheng J, Danioko S, Rezaie A, Sajjadi SA, Rakovski C
Combined use of Donepezil and Memantine increases the probability of five-year survival of Alzheimer's disease patients.
Commun Med (Lond). 2024 May 23;4(1):99. PubMed.PAPER Bhadane P, Roul K, Belemkar S, Kumar D
Immunotherapeutic approaches for Alzheimer's disease: Exploring active and passive vaccine progress.
Brain Res. 2024 May 21;:149018. PubMed.PAPER Pan Y, Wallace TC, Karosas T, Bennett DA, Agarwal P, Chung M
Association of Egg Intake With Alzheimer's Dementia Risk in Older Adults: The Rush Memory and Aging Project.
J Nutr. 2024 May 21; PubMed.PAPER Benatar M, Hansen T, Rom D, Geist MA, Blaettler T, Camu W, Kuzma-Kozakiewicz M, van den Berg LH, Morales RJ, Chio A, Andersen PM, Pradat PF, Lange D, Van Damme P, Mora G, Grudniak M, Elliott M, Petri S, Olney N, Ladha S, Goyal NA, Meyer T, Hanna MG, Quinn C, Genge A, Zinman L, Jabari D, Shoesmith C, Ludolph AC, Neuwirth C, Nations S, Shefner JM, Turner MR, Wuu J, Bennett R, Dang H, Sundgreen C, ORARIALS-01 trial team
Safety and efficacy of arimoclomol in patients with early amyotrophic lateral sclerosis (ORARIALS-01): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.
Lancet Neurol. 2024 May 20; PubMed.PAPER Trubshaw M, Gohil C, Yoganathan K, Kohl O, Edmond E, Proudfoot M, Thompson AG, Talbot K, Stagg CJ, Nobre AC, Woolrich M, Turner MR
The cortical neurophysiological signature of amyotrophic lateral sclerosis.
Brain Commun. 2024;6(3):fcae164. Epub 2024 May 13 PubMed.Autopsies Confirm That PI-2620 Binds 4R Tau Deposits
RESEARCH NEWS 2024-05-23 Research News The hunt for PET tracers that can detect four-repeat tau deposits has turned up two ligands, PI-2620 and APN-1607, that bind these fibrils, but neither has yet been validated for diagnostic use. In a May 7 preprint on bioRxiv, researchers le
Makoto Higuchi on Autopsies Confirm That PI-2620 Binds 4R Tau Deposits
COMMENT In this work, Slemann and colleagues utilized tau-transgenic mice and brain sections derived from PSP patients who had undergone PET scans, along with sections from a brain bank, to demonstrate the ability of a tau PET probe, 18F PI2620, to capture four-r
Rik Ossenkoppele on Autopsies Confirm That PI-2620 Binds 4R Tau Deposits
COMMENT Like other tau PET tracers, for example MK6240, flortaucipir, and RO948, PI2620 has shown excellent diagnostic performance in distinguishing symptomatic AD from other neurodegenerative disorders. An open question is whether PI2620 can also be utilized for
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