6135 RESULTS
RESEARCH NEWS 1998-08-20 Research News It has been theorized that cell membranes contain stable regions consisting of glycolipids and cholesterol. They are called detergent-insoluble glycolipid-enriched membrane domains (DIGs), or, more picturesquely, "rafts." These raf
RESEARCH NEWS 1998-08-14 Research News Transcription factors of the nuclear factor-kB/rel (NF-kB) family may be important in cell survival by regulating unidentified, antiapoptotic genes. One such gene that protects cells from apoptosis induced by Fas or tumor necrosis factor typ
RESEARCH NEWS 1998-08-14 Research News Acetylcholine has different effects on the excitability of different neuronal types, according to work by Xiang, et al, published in today's Science. The researchers examined two subtypes of interneurons in layer V of rat visual cortex.
RESEARCH NEWS 1998-08-14 Research News Maybe it is time to give up steak in order to live longer—at least if you are a fruit fly. According to a study published today in Science, a diet of sugar keeps flies in a metabolic "waiting mode," in which both reproduction and d
RESEARCH NEWS 1998-08-13 Research News An enzyme in Caenorhabditis elegans affects the rate at which the dainty worms age, by modulating the cellular response to oxidative stress. In today's Nature, Naoaki Ishii and his colleagues at the Tokai University School of Medicine,
CONFERENCE COVERAGE 1998-07-22 Conference Coverage Because presenilin was discovered in positional cloning experiments involving large familial Alzheimer's disease kindreds, there were no previous data concerning its biological function. As a result, many groups have used a variet
CONFERENCE COVERAGE 1998-07-22 Conference Coverage Note: This article was revised on 10 August, 1998, to accommodate some factual corrections. See also R. Tanzi's comment, appended below. 22 July 1998. A study published last year by Margaret Pericak-Vance et al. (JAMA 1997;278) re
CONFERENCE COVERAGE 1998-07-22 Conference Coverage Yamaguchi (Abstract 1245) presented his theory that very diffuse plaques within nondemented individuals are cleared by astrocytic phagocytosis. He showed many examples of very diffuse Aβ-positive staining within the brains of 40-50 yea
CONFERENCE COVERAGE 1998-07-22 Conference Coverage A new epidemic of "mad tau disease" swept Amsterdam at the workshop on Hereditary Fronto-Temporal Dementia and Pick's disease. Fronto-temporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) has been linked t
CONFERENCE COVERAGE 1998-07-22 Conference Coverage While a number of drug companies have been pumping big bucks into creating novel molecules capable of inhibiting formation of Aβ fibrils, along comes Alan Snow and his colleagues at the University of Washington and his Seattle-based co
CONFERENCE COVERAGE 1998-07-21 Conference Coverage If you came to Amsterdam hoping to hear a lot of new data on Aβ peptide inhibitors, you might have learned more by window shopping in the red-light district. This doesn't mean that the session was without merit. Barbara Cordell (A
CONFERENCE COVERAGE 1998-07-21 Conference Coverage Over a decade ago, John Blass and his colleagues proposed that AD was caused by compromised metabolism. Today, this theory has gained support from a convergence of numerous therapeutic, pathological and biochemical studies pointing to
CONFERENCE COVERAGE 1998-07-21 Conference Coverage 21 July 1998. The focus of this symposium was the biology and diagnostic value of a recently discovered protein, termed AD7c-neuronal thread protein (NTP), in Alzheimer's disease (AD). Dr. Suzanne de la Monte presented the discove
CONFERENCE COVERAGE 1998-07-20 Conference Coverage The "great amyloid debate" appeared to resolve at least one issue in the rather contentious arena of defining the critical neuropathological events in AD. Amyloid per se, i.e., "extracellular, fibrillar, congophilic depo
CONFERENCE COVERAGE 1998-07-20 Conference Coverage Aβ's fibril-formation processes were revealed in a tour de force of atomic force microscopy by Harper (Abstract 909). The initial species to be detected are four nm globular assemblies which range in size from 1.4 to 14 nm. He ind
