COMMENT Harnessing the peripheral immune system as a neuroprotective therapeutic approach to Alzheimer's disease: Discussion regarding pathways and mechanism Immunotherapy targeting the programmed death protein (PD)-1/PD-L1 pathway was shown to be effective ...
GRANT Tuesday, July 14, 2020- 10:45 Race Against Dementia and Alzheimer's Research UK Up to £500,000 20 January 2021 Race Against Dementia Fellowship ...
PAPER Hernández-Sapiéns MA, Reza-Zaldívar EE, Cevallos RR, Márquez-Aguirre AL, Gazarian K, Canales-Aguirre AA
A Three-Dimensional Alzheimer's Disease Cell Culture Model Using iPSC-Derived Neurons Carrying A246E Mutation in PSEN1.Front Cell Neurosci. 2020;14:151. Epub 2020 Jun 12 PubMed: 32655369
COMMENT This fantastic work shows lateral trapping of γ-secretase forming transient hot spots on the plasma membrane. The comments posted so far are insightful in calling for more high-resolution studies to understand the mechanisms of action of how these hot ...
COMMENT I find the work of Tony Wyss-Coray’s laboratory absolutely fascinating. It reveals a differentiated look at the BBB and how it changes under conditions of physiological aging. It is very relevant for our work. Many labs, including ours, aim to use ...
COMMENT This article supports two themes that have been developing: cognitive reserve and brain maintenance. Brain maintenance is the idea that life enrichment might actually maintain the brain itself, and thus the brain areas/networks underlying cognitive ...
Rooty Hill, Australia
PAPER Sharkey LM, Sandoval-Pistorius SS, Moore SJ, Gerson JE, Komlo R, Fischer S, Negron-Rios KY, Crowley EV, Padron F, Patel R, Murphy GG, Paulson HL
Modeling UBQLN2-mediated neurodegenerative disease in mice: Shared and divergent properties of wild type and mutant UBQLN2 in phase separation, subcellular localization, altered proteostasis pathways, and selective cytotoxicity.Neurobiol Dis. 2020 Jul 9;:105016. PubMed: 32653673
PAPER Ma Y, Klein HU, De Jager PL32654306
PAPER Detrez JR, Ben-Nejma IR, Van Kolen K, Van Dam D, De Deyn PP, Fransen E, Verhoye M, Timmermans JP, Nuydens R, Van der Linden A, Keliris GA, De Vos WH
Progressive tau aggregation does not alter functional brain network connectivity in seeded hTau.P301L mice.Neurobiol Dis. 2020 Jul 9;:105011. PubMed: 32653674
PAPER Weerasekera A, Crabbé M, Tomé SO, Gsell W, Sima D, Casteels C, Dresselaers T, Deroose C, Van Huffel S, Rudolf Thal D, Van Damme P, Himmelreich U
Non-invasive characterization of amyotrophic lateral sclerosis in a hTDP-43A315T mouse model: A PET-MR study.Neuroimage Clin. 2020 Jun 25;27:102327. PubMed: 32653817
PAPER Smith AR, Mill J, Lunnon K32654324
PAPER Thomas MS, Ojinaga Alfageme O, D'Souza H, Patkee PA, Rutherford MA, Mok KY, Hardy J, Karmiloff-Smith A, LonDownS Consortium
A multi-level developmental approach to exploring individual differences in Down syndrome: genes, brain, behaviour, and environment.Res Dev Disabil. 2020 Jul 9;104:103638. PubMed: 32653761
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