. Serotonergic system genes in psychosis of Alzheimer dementia: meta-analysis. Am J Geriatr Psychiatry. 2009 Oct;17(10):839-46. PubMed.


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  1. Delusions, psychosis, and aggression that occur in a majority of patients with AD is difficult to treat with either pharmacological or psychosocial/environmental approaches.
    This review suggests that the HTR2A T102C polymorphism, in particular, is a significant risk factor for delusions and/or hallucinations in AD, while the SLC6A4 polymorphism was not.

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