Howell JC, Watts KD, Parker MW, Wu J, Kollhoff A, Wingo TS, Dorbin CD, Qiu D, Hu WT. Race modifies the relationship between cognition and Alzheimer's disease cerebrospinal fluid biomarkers. Alzheimers Res Ther. 2017 Nov 2;9(1):88. PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : Aβ40 (CSF)
- CTRL vs AD : Aβ40 (CSF)
- AD vs CTRL : Aβ42 (CSF)
- CTRL vs AD : Aβ42 (CSF)
- AD vs CTRL : NFL (CSF)
- CTRL vs AD : NFL (CSF)
- AD vs CTRL : tau-p181 (CSF)
- CTRL vs AD : tau-p181 (CSF)
- AD vs CTRL : tau-total (CSF)
- CTRL vs AD : tau-total (CSF)
- AD vs CTRL : α-synuclein (CSF)
- CTRL vs AD : α-synuclein (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| Aβ40 (CSF) |
AD (10) |
9.49 ± 3.61 ng/mL § |
ELISA; Innotest; Fujirebio |
McKhann et al., 1984; Dubois et al., 2007 |
| Aβ40 (CSF) |
AD (15) |
7.91 ± 2.54 ng/mL § |
ELISA; Innotest; Fujirebio |
McKhann et al., 1984; Dubois et al., 2007 |
| Aβ40 (CSF) |
CTRL- CNC (23) |
7.21 ± 1.96 ng/mL § |
ELISA; Innotest; Fujirebio |
|
| Aβ40 (CSF) |
CTRL- CNC (28) |
10.03 ± 3.65 ng/mL § |
ELISA; Innotest; Fujirebio |
|
| Aβ42 (CSF) |
AD (10) |
158 ± 105 pg/mL § |
xMAP; INNOBIA AlzBio3; Fujirebio |
McKhann et al., 1984; Dubois et al., 2007 |
| Aβ42 (CSF) |
AD (15) |
96 ± 61 pg/mL § |
xMAP; INNOBIA AlzBio3; Fujirebio |
McKhann et al., 1984; Dubois et al., 2007 |
| Aβ42 (CSF) |
CTRL- CNC (23) |
273 ± 110 pg/mL § |
xMAP; INNOBIA AlzBio3; Fujirebio |
|
| Aβ42 (CSF) |
CTRL- CNC (28) |
250 ± 131 pg/mL § |
xMAP; INNOBIA AlzBio3; Fujirebio |
|
| NFL (CSF) |
AD (10) |
1570.8 ± 865.8 pg/mL § |
ELISA; NF-light; UmanDiagnostics AB |
McKhann et al., 1984; Dubois et al., 2007 |
| NFL (CSF) |
AD (15) |
1176.27 ± 599.93 pg/mL § |
ELISA; NF-light; UmanDiagnostics AB |
McKhann et al., 1984; Dubois et al., 2007 |
| NFL (CSF) |
CTRL- CNC (23) |
673.83 ± 459.31 pg/mL § |
ELISA; NF-light; UmanDiagnostics AB |
|
| NFL (CSF) |
CTRL- CNC (28) |
1026.93 ± 570.44 pg/mL § |
ELISA; NF-light; UmanDiagnostics AB |
|
| tau-p181 (CSF) |
AD (10) |
25.3 ± 10.3 pg/mL § |
xMAP; INNOBIA AlzBio3; Fujirebio |
McKhann et al., 1984; Dubois et al., 2007 |
| tau-p181 (CSF) |
AD (15) |
34.2 ± 14.9 pg/mL § |
xMAP; INNOBIA AlzBio3; Fujirebio |
McKhann et al., 1984; Dubois et al., 2007 |
| tau-p181 (CSF) |
CTRL- CNC (23) |
13.8 ± 5.1 pg/mL § |
xMAP; INNOBIA AlzBio3; Fujirebio |
|
| tau-p181 (CSF) |
CTRL- CNC (28) |
22.5 ± 9.8 pg/mL § |
xMAP; INNOBIA AlzBio3; Fujirebio |
|
| tau-total (CSF) |
AD (10) |
72.8 ± 27.5 pg/mL § |
xMAP; INNOBIA AlzBio3; Fujirebio |
McKhann et al., 1984; Dubois et al., 2007 |
| tau-total (CSF) |
AD (15) |
103.8 ± 72.9 pg/mL § |
xMAP; INNOBIA AlzBio3; Fujirebio |
McKhann et al., 1984; Dubois et al., 2007 |
| tau-total (CSF) |
CTRL- CNC (23) |
36.3 ± 12 pg/mL § |
xMAP; INNOBIA AlzBio3; Fujirebio |
|
| tau-total (CSF) |
CTRL- CNC (28) |
58.6 ± 29 pg/mL § |
xMAP; INNOBIA AlzBio3; Fujirebio |
|
| α-synuclein (CSF) |
AD (10) |
483.83 ± 339.07 pg/mL § |
ELISA; Novex; Thermo Fisher Scientific |
McKhann et al., 1984; Dubois et al., 2007 |
| α-synuclein (CSF) |
AD (15) |
443.19 ± 279.9 pg/mL § |
ELISA; Novex; Thermo Fisher Scientific |
McKhann et al., 1984; Dubois et al., 2007 |
| α-synuclein (CSF) |
CTRL- CNC (23) |
295.99 ± 295.33 pg/mL § |
ELISA; Novex; Thermo Fisher Scientific |
|
| α-synuclein (CSF) |
CTRL- CNC (28) |
458.38 ± 451.08 pg/mL § |
ELISA; Novex; Thermo Fisher Scientific |
§ Data supplied to Alzforum by author
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