Kang DE, Soriano S, Frosch MP, Collins T, Naruse S, Sisodia SS, Leibowitz G, Levine F, Koo EH. Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway. J Neurosci. 1999 Jun 1;19(11):4229-37. PubMed.
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Osaka City University Medical School
It is necessary for us to know the molecular link between PS-1 and gene products involved in development from the viewpoint of possible therapy. GSK-3 and b-catenin are among the most plausible species to regulate PS-1 function.
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