. New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage. Nat Cell Biol. 2001 May;3(5):507-11. PubMed.


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  1. It is an unexpected finding of the occurrence of an inhibitor to block APP-gamma secretase but not Notch processing. Although we do not know the physiological function of the soluble secreted amyloid protein, it is now potent to exclusively regulate APP metabolism.

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