Petit A, Bihel F, Alvès da Costa C, Pourquié O, Checler F, Kraus JL.
New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage.
Nat Cell Biol. 2001 May;3(5):507-11.
PubMed.
It is an unexpected finding of the occurrence of an inhibitor to block APP-gamma secretase but not Notch processing. Although we do not know the physiological function of the soluble secreted amyloid protein, it is now potent to exclusively regulate APP metabolism.
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Osaka City University Medical School
It is an unexpected finding of the occurrence of an inhibitor to block APP-gamma secretase but not Notch processing. Although we do not know the physiological function of the soluble secreted amyloid protein, it is now potent to exclusively regulate APP metabolism.
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