. Mutated ATP10B increases Parkinson's disease risk by compromising lysosomal glucosylceramide export. Acta Neuropathol. 2020 Jun;139(6):1001-1024. Epub 2020 Mar 14 PubMed.

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  1. This is an interesting study that highlights the importance of lysosomal function and lipid homeostasis in synucleinopathies. The findings also suggest a converging mechanism between mutations in ATP10B and GBA1 via accumulation of glucosylceramide.

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