. Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease. J Biol Chem. 2000 Mar 10;275(10):7410-5. PubMed.


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  1. It is very interesting and desiralbe to enhance the present study because cerebral LRP blockade may be a new anti-AD therapy.

  2. This is a very interesting report. As suggested by the authors, it could lead to the discovery of pharmacological agents that decrease amyloid production by acting on LRP.

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  1. Research Brief: Novel Sorting Protein May Affect Amyloid Production