. Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease. J Biol Chem. 2000 Mar 10;275(10):7410-5. PubMed.


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  1. This is a very interesting report. As suggested by the authors, it could lead to the discovery of pharmacological agents that decrease amyloid production by acting on LRP.

  2. It is very interesting and desiralbe to enhance the present study because cerebral LRP blockade may be a new anti-AD therapy.

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  1. Research Brief: Novel Sorting Protein May Affect Amyloid Production