Enard W, Khaitovich P, Klose J, Zöllner S, Heissig F, Giavalisco P, Nieselt-Struwe K, Muchmore E, Varki A, Ravid R, Doxiadis GM, Bontrop RE, Pääbo S. Intra- and interspecific variation in primate gene expression patterns. Science. 2002 Apr 12;296(5566):340-3. PubMed.

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- George Church
- Posted: 14 Apr 2002
- News: It's All in the Dose: Protein Levels, Not Structures, May Separate Us from Chimps
Its very nice to see the beginnings of a test for the King & Wilson 1975 idea, (especially for both RNA and protein). There's still a long way to go to dissect out the quantitative effects on the alternative splice forms for the various mRNAs in the plethora of cell-types within the brain. The subset of differences relevant to neurodegenerative disease differences among apes will probably be harder to disentangle than a similar approach entirely within human families/populations, where the number of differences can be more focused and relevant (but time will tell)."

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