. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet. 2000 Jul;25(3):302-5. PubMed.


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  1. Not enough attention is paid to normal mechanisms of protein turnover as a contributing factor in neurodegenerative diseases. Mutations involving ubiquitin ligases are the first of many proteins that are likely to be invoved in ubiuquitin-mediated degradation of proteins that accumulate in abnormal amounts in the CNS.

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