Andreasen N, Gottfries J, Vanmechelen E, Vanderstichele H, Davidson P, Blennow K, Rosengren L, Blennow K. Evaluation of CSF biomarkers for axonal and neuronal degeneration, gliosis, and beta-amyloid metabolism in Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2001 Oct;71(4):557-8. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ42
(CSF)		 AD
(35)		 748 ± 297
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
Aβ42
(CSF)		 CTRL-
CNC
(19)		 1623 ± 429
pg/mL		 ELISA;
Innotest;
Innogenetics
GFAP
(CSF)		 AD
(35)		 717 ± 250
pg/mL		 ELISA;
Other/Not Specified;
In-house		 McKhann et al., 1984
GFAP
(CSF)		 CTRL-
CNC
(19)		 860 ± 297
pg/mL		 ELISA;
Other/Not Specified;
In-house
NFL
(CSF)		 AD
(35)		 615 ± 456
pg/mL		 ELISA;
Other/Not Specified;
In-house		 McKhann et al., 1984
NFL
(CSF)		 CTRL-
CNC
(19)		 295 ± 194
pg/mL		 ELISA;
Other/Not Specified;
In-house
NSE
(CSF)		 AD
(35)		 7.4 ± 2.7
ng/mL		 ELISA;
Other/Not Specified;
Sangtec Medical		 McKhann et al., 1984
NSE
(CSF)		 CTRL-
CNC
(19)		 6.9 ± 2.1
ng/mL		 ELISA;
Other/Not Specified;
Sangtec Medical
tau-total
(CSF)		 AD
(35)		 634 ± 288
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-total
(CSF)		 CTRL-
CNC
(19)		 375 ± 171
pg/mL		 ELISA;
Innotest;
Innogenetics

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