Yun SM, Cho SJ, Jo C, Park MH, Han C, Koh YH. Elevation of plasma soluble amyloid precursor protein beta in Alzheimer's disease. Arch Gerontol Geriatr. 2020 Mar - Apr;87:103995. Epub 2019 Dec 9 PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : sAPPα (Plasma and Serum)
- CTRL vs AD : sAPPα (Plasma and Serum)
- AD vs CTRL : sAPPβ (Plasma and Serum)
- CTRL vs AD : sAPPβ (Plasma and Serum)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| sAPPα (Plasma) |
AD (52) |
48.7 ± 3.9† ng/mL |
ELISA; cat # 27734; Immuno-Biological Laboratories |
McKhann et al., 1984 |
| sAPPα (Plasma) |
CTRL- CNC (114) |
41.8 ± 2.3† ng/mL |
ELISA; cat # 27734; Immuno-Biological Laboratories |
|
| sAPPβ (Plasma) |
AD (52) |
6.8 ± 0.6† ng/mL |
ELISA; cat # 27732; Immuno-Biological Laboratories |
McKhann et al., 1984 |
| sAPPβ (Plasma) |
CTRL- CNC (114) |
5.1 ± 0.2† ng/mL |
ELISA; cat # 27732; Immuno-Biological Laboratories |
† Mean ± SEM
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