Turnbull IR, Gilfillan S, Cella M, Aoshi T, Miller M, Piccio L, Hernandez M, Colonna M. Cutting edge: TREM-2 attenuates macrophage activation. J Immunol. 2006 Sep 15;177(6):3520-4. PubMed.

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Research Models

  1. Trem2 KO (Colonna)
  2. Trem2 KO (Colonna) x 5XFAD
  3. Trem2 KO (Colonna) x PS19
  4. TREM2, humanized (common variant) X 5XFAD
  5. TREM2, humanized (R47H) X 5XFAD
  6. TREM2, humanized (common variant)
  7. TREM2, humanized (R47H)
  8. PS19 with humanized TREM2 (common variant)
  9. PS19 with humanized TREM2 (R47H)