Cheng YW, Chiu MJ, Chen YF, Cheng TW, Lai YM, Chen TF. The contribution of vascular risk factors in neurodegenerative disorders: from mild cognitive impairment to Alzheimer's disease. Alzheimers Res Ther. 2020 Aug 4;12(1):91. PubMed.
AlzBiomarker Database
Meta-Analysis
- MCI-AD vs MCI-Stable : Aβ40 (Plasma and Serum)
- MCI-AD vs MCI-Stable : Aβ42 (Plasma and Serum)
- MCI-AD vs MCI-Stable : tau-total (Plasma and Serum)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| Aβ40 (Plasma) |
MCI-AD (53) |
46.85 ± 13.95 pg/mL |
Immunomagnetic Reduction; MF-AB0-0060; MagQu Co. Ltd. |
McKhann et al., 2011; Albert et al., 2011 |
| Aβ40 (Plasma) |
MCI-Stable (155) |
50.33 ± 10.7 pg/mL |
Immunomagnetic Reduction; MF-AB0-0060; MagQu Co. Ltd. |
Albert et al., 2011 |
| Aβ42 (Plasma) |
MCI-AD (53) |
19.38 ± 2.53 pg/mL |
Immunomagnetic Reduction; MF-AB2-0060; MagQu Co. Ltd. |
McKhann et al., 2011; Albert et al., 2011 |
| Aβ42 (Plasma) |
MCI-Stable (155) |
16.94 ± 3.49 pg/mL |
Immunomagnetic Reduction; MF-AB2-0060; MagQu Co. Ltd. |
Albert et al., 2011 |
| tau-total (Plasma) |
MCI-AD (53) |
38.16 ± 9.74 pg/mL |
Immunomagnetic Reduction; MF-TAU-0060; MagQu Co. Ltd. |
McKhann et al., 2011; Albert et al., 2011 |
| tau-total (Plasma) |
MCI-Stable (155) |
25.06 ± 13.28 pg/mL |
Immunomagnetic Reduction; MF-TAU-0060; MagQu Co. Ltd. |
Albert et al., 2011 |
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