Wong GT, Manfra D, Poulet FM, Zhang Q, Josien H, Bara T, Engstrom L, Pinzon-Ortiz M, Fine JS, Lee HJ, Zhang L, Higgins GA, Parker EM. Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J Biol Chem. 2004 Mar 26;279(13):12876-82. PubMed.

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Comments

  1. A mechanism to inhibit partially PS1 expression without modifying Notch activity has been postulated in our recent paper in FEBS Letters. It should be noted that the compound used is physiologically produced in the right amount in young people and strongly reduced in the elderly. We would like to see our paper considered in the course of this discussion.

    References:

    Scarpa S, Fuso A, D'Anselmi F, Cavallaro RA. Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease?. FEBS Lett. 2003 Apr 24;541(1-3):145-8. PubMed.

    View all comments by Sigfrido Scarpa

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