. Chronic administration of docosahexaenoic acid ameliorates the impairment of spatial cognition learning ability in amyloid beta-infused rats. J Nutr. 2005 Mar;135(3):549-55. PubMed.


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  1. This study demonstrates the effect of DHA on enhancing memory function. However, as I point out in this article, I thought two things should have been emphasized more and noted in the abstract, but weren't:

    1) Soluble beta-amyloid had no reproducible effect on cognition impairment

    2) Aluminum chloride was used to cause the aggregation of the beta-amyloid; therefore, the infusion was also infusing the brains of the rats with aluminum.

    While the focus of the study was the benefits of DHA, these are important to emphasize and note in the abstract, simply because the role of beta-amyloid in Alzheimer's is controversial. The differences between the effect of soluble and insoluble beta-amyloid should be emphasized, as well as possible confounding factors such as aluminum.

    Chris Masterjohn

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