. Cerebrospinal fluid phospho-tau, total tau and beta-amyloid(1-42) in the differentiation between Alzheimer's disease and vascular dementia. Dement Geriatr Cogn Disord. 2002;14(4):183-90. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)
Cohort
(N)
Measurement
Mean ± SD
Method;
Assay Name;
Manufacturer
Diagnostic
Criteria
Aβ42
(CSF)
AD-
Possible Alzheimer's Disease
(23)
448.91 ± 132.45
pg/mL §
ELISA;
Innotest;
Innogenetics
McKhann et al., 1984
Aβ42
(CSF)
AD-
Probable Alzheimer's Disease
(50)
441.1 ± 131.92
pg/mL §
ELISA;
Innotest;
Innogenetics
McKhann et al., 1984
Aβ42
(CSF)
CTRL-
Other Controls
(27)
792.3 ± 181.44
pg/mL §
ELISA;
Innotest;
Innogenetics
Aβ42
(CSF)
CTRL-
Other Controls
(27)
792.3 ± 181.44
pg/mL §
ELISA;
Innotest;
Innogenetics
Aβ42
(CSF)
VaD-
Possible VaD
(39)
512.77 ± 189
pg/mL §
ELISA;
Innotest;
Innogenetics
Román et al., 1993
Aβ42
(CSF)
VaD-
Probable VaD
(36)
445.53 ± 163.34
pg/mL §
ELISA;
Innotest;
Innogenetics
Román et al., 1993
tau-p181
(CSF)
AD-
Possible Alzheimer's Disease
(23)
18.33 ± 8.18
pM §
ELISA;
Other/Not Specified;
In-house
McKhann et al., 1984
tau-p181
(CSF)
AD-
Probable Alzheimer's Disease
(50)
19.96 ± 6.61
pM §
ELISA;
Other/Not Specified;
In-house
McKhann et al., 1984
tau-p181
(CSF)
CTRL-
Other Controls
(27)
15.13 ± 4.54
pM §
ELISA;
Other/Not Specified;
In-house
tau-p181
(CSF)
CTRL-
Other Controls
(27)
15.13 ± 4.54
pM §
ELISA;
Other/Not Specified;
In-house
tau-p181
(CSF)
VaD-
Possible VaD
(39)
14.85 ± 6.46
pM §
ELISA;
Other/Not Specified;
In-house
Román et al., 1993
tau-p181
(CSF)
VaD-
Probable VaD
(36)
15.78 ± 7.31
pM §
ELISA;
Other/Not Specified;
In-house
Román et al., 1993
tau-total
(CSF)
AD-
Possible Alzheimer's Disease
(23)
667.04 ± 491.05
pg/mL §
ELISA;
Innotest;
Innogenetics
McKhann et al., 1984
tau-total
(CSF)
AD-
Probable Alzheimer's Disease
(50)
652.42 ± 307.87
pg/mL §
ELISA;
Innotest;
Innogenetics
McKhann et al., 1984
tau-total
(CSF)
CTRL-
Other Controls
(27)
369.56 ± 200.36
pg/mL §
ELISA;
Innotest;
Innogenetics
tau-total
(CSF)
CTRL-
Other Controls
(27)
369.56 ± 200.36
pg/mL §
ELISA;
Innotest;
Innogenetics
tau-total
(CSF)
VaD-
Possible VaD
(39)
584.44 ± 569.71
pg/mL §
ELISA;
Innotest;
Innogenetics
Román et al., 1993
tau-total
(CSF)
VaD-
Probable VaD
(36)
604.78 ± 486.89
pg/mL §
ELISA;
Innotest;
Innogenetics
Román et al., 1993

§ Data supplied to Alzforum by author

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