Nägga K, Gottfries J, Blennow K, Marcusson J. Cerebrospinal fluid phospho-tau, total tau and beta-amyloid(1-42) in the differentiation between Alzheimer's disease and vascular dementia. Dement Geriatr Cogn Disord. 2002;14(4):183-90. PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : Aβ42 (CSF)
- CTRL vs AD : Aβ42 (CSF)
- VaD vs AD : Aβ42 (CSF)
- AD vs CTRL : tau-p181 (CSF)
- CTRL vs AD : tau-p181 (CSF)
- VaD vs AD : tau-p181 (CSF)
- AD vs CTRL : tau-total (CSF)
- CTRL vs AD : tau-total (CSF)
- VaD vs AD : tau-total (CSF)
Curated Study Data
Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
---|---|---|---|---|
Aβ42 (CSF) |
AD- Possible Alzheimer's Disease (23) |
448.91 ± 132.45 pg/mL § |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
Aβ42 (CSF) |
AD- Probable Alzheimer's Disease (50) |
441.1 ± 131.92 pg/mL § |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
Aβ42 (CSF) |
CTRL- Other Controls (27) |
792.3 ± 181.44 pg/mL § |
ELISA; Innotest; Innogenetics |
|
Aβ42 (CSF) |
CTRL- Other Controls (27) |
792.3 ± 181.44 pg/mL § |
ELISA; Innotest; Innogenetics |
|
Aβ42 (CSF) |
VaD- Possible VaD (39) |
512.77 ± 189 pg/mL § |
ELISA; Innotest; Innogenetics |
Román et al., 1993 |
Aβ42 (CSF) |
VaD- Probable VaD (36) |
445.53 ± 163.34 pg/mL § |
ELISA; Innotest; Innogenetics |
Román et al., 1993 |
tau-p181 (CSF) |
AD- Possible Alzheimer's Disease (23) |
18.33 ± 8.18 pM § |
ELISA; Other/Not Specified; In-house |
McKhann et al., 1984 |
tau-p181 (CSF) |
AD- Probable Alzheimer's Disease (50) |
19.96 ± 6.61 pM § |
ELISA; Other/Not Specified; In-house |
McKhann et al., 1984 |
tau-p181 (CSF) |
CTRL- Other Controls (27) |
15.13 ± 4.54 pM § |
ELISA; Other/Not Specified; In-house |
|
tau-p181 (CSF) |
CTRL- Other Controls (27) |
15.13 ± 4.54 pM § |
ELISA; Other/Not Specified; In-house |
|
tau-p181 (CSF) |
VaD- Possible VaD (39) |
14.85 ± 6.46 pM § |
ELISA; Other/Not Specified; In-house |
Román et al., 1993 |
tau-p181 (CSF) |
VaD- Probable VaD (36) |
15.78 ± 7.31 pM § |
ELISA; Other/Not Specified; In-house |
Román et al., 1993 |
tau-total (CSF) |
AD- Possible Alzheimer's Disease (23) |
667.04 ± 491.05 pg/mL § |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
tau-total (CSF) |
AD- Probable Alzheimer's Disease (50) |
652.42 ± 307.87 pg/mL § |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
tau-total (CSF) |
CTRL- Other Controls (27) |
369.56 ± 200.36 pg/mL § |
ELISA; Innotest; Innogenetics |
|
tau-total (CSF) |
CTRL- Other Controls (27) |
369.56 ± 200.36 pg/mL § |
ELISA; Innotest; Innogenetics |
|
tau-total (CSF) |
VaD- Possible VaD (39) |
584.44 ± 569.71 pg/mL § |
ELISA; Innotest; Innogenetics |
Román et al., 1993 |
tau-total (CSF) |
VaD- Probable VaD (36) |
604.78 ± 486.89 pg/mL § |
ELISA; Innotest; Innogenetics |
Román et al., 1993 |
§ Data supplied to Alzforum by author
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