Henneman WJ, Vrenken H, Barnes J, Sluimer IC, Verwey NA, Blankenstein MA, Klein M, Fox NC, Scheltens P, Barkhof F, van der Flier WM. Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease. Neurology. 2009 Sep 22;73(12):935-40. PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : Aβ42 (CSF)
- CTRL vs AD : Aβ42 (CSF)
- AD vs CTRL : tau-p181 (CSF)
- CTRL vs AD : tau-p181 (CSF)
- AD vs CTRL : tau-total (CSF)
- CTRL vs AD : tau-total (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| Aβ42 (CSF) |
AD (31) |
402 ± 113 pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| Aβ42 (CSF) |
CTRL- Other Controls (19) |
688 ± 251 pg/mL |
ELISA; Innotest; Innogenetics |
|
| tau-p181 (CSF) |
AD (31) |
92 ± 38 pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| tau-p181 (CSF) |
CTRL- Other Controls (19) |
63 ± 35 pg/mL |
ELISA; Innotest; Innogenetics |
|
| tau-total (CSF) |
AD (31) |
811 ± 486 pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| tau-total (CSF) |
CTRL- Other Controls (19) |
432 ± 394 pg/mL |
ELISA; Innotest; Innogenetics |
Recommends
Please login to recommend the paper.
Comments
Global Alzheimer's Platform Foundation
This is an interesting paper that adds additional information about the value of multiple biomarkers as predictors of future decline in older persons. Specifically, CSF pTau predicted subsequent hippocampal atrophy independent of baseline atrophy and cognitive impairment. These data add to our knowledge about the utility of individual and combinations of biomarkers for predicting subsequent neurodegeneration.
Make a Comment
To make a comment you must login or register.