. BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice. J Neurochem. 2006 Dec;99(6):1555-63. PubMed.


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  1. The proof of concept on low-cost mice is interesting, and likely more relevant (see also El Mouedden et al., 2006).


    . Reduction of Abeta levels in the Sprague Dawley rat after oral administration of the functional gamma-secretase inhibitor, DAPT: a novel non-transgenic model for Abeta production inhibitors. Curr Pharm Des. 2006;12(6):671-6. PubMed.

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