332001 RESULTS
COMMENT The APOE4 allele constitutes a unique case among common genetic variants of chronic diseases, exerting a major influence on Alzheimer’s disease (AD) risk. AD also associates with three other distinct genetic forms, featuring rare variants of high effect,
RESEARCH NEWS 2024-05-10 Research News For 30 years, APOE4 has ranked as the strongest genetic risk factor for Alzheimer’s disease, with two copies boosting the odds up to 15-fold. Now, scientists make the case that people with two APOE4 alleles are not merely at risk, but are de
COMMENT Is late-onset, “sporadic” Alzheimer’s disease genetic? Is this a trick question? Ever since Strittmatter and Roses published the first evidence of the association between ApoE and Aβ-amyloid in 1993 (Strittmatter et al., 1993), and as long as he lived, Al
PAPER Burnham SC, Cox T, Benzinger T, et al
COMMENT Perspective on the findings and their implications. Age-related Alzheimer’s disease (AD) is a neurodegenerative disorder with a complex pattern of genetic and environmental factors contributing to its pathogenesis. One gene stands, however, central for ri
COMMENT I think this paper is helpful in putting some biomarker and neuropathology heft behind the growing consensus in the field that E4 homozygosity, in European ancestry individuals at least, is all but deterministic for the development of Alzheimer’s disease
COMMENT The authors of this manuscript analyzed, together, data from a number of previously published studies and comment that: “Findings revealed that almost all APOE4 homozygotes exhibited AD pathology and had significantly higher levels of AD biomarkers from a
COMMENT We commend Fortea and colleagues for their analyses examining biomarker and clinical changes in a large number of cognitively impaired and unimpaired persons from NACC, Alfa plus, A4 trial, OASIS, ADNI, and WRAP. In general, the results from their retrosp
Icahn School of Medicine at Mount Sinai
PAPER Lu L, Deng Y, Xu R
PAPER Sin YY, Cameron RT, Schepers M, MacLeod R, Wright TA, Paes D, van den Hove D, Willems E, Vanmierlo T, Prickaerts J, Blair CM, Baillie GS
PAPER Chen YH, Wang C, Kurth T
PAPER Magagnoli J, Sutton SS, Ambati J
PAPER Xiong M, Dahlén A, Roshanbin S, Wik E, Aguilar X, Eriksson J, Sehlin D, Syvänen S
PAPER Gang Y, Li T, Xu X, Zheng Q, Wang W
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