PAPER Chen J, Song Y, Ma L, Jin Y, Yu J, Guo Y, Huang Y, Pu X

Computational insights into diverse binding modes of the allosteric modulator and their regulation on dopamine D1 receptor.

Comput Biol Med. 2024 May;173:108283. Epub 2024 Mar 20 PubMed: 38552278

PAPER Sibley DR, Luderman KD, Free RB, Shi L

Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential.

Signal Transduct Target Ther. 2021 May 22;6(1):205. PubMed: 34023856

PAPER Bai M, Jia S, Zhang J, Cheng HG, Cong H, Liu S, Huang Z, Huang Y, Chen X, Zhou Q

A Modular Approach for Diversity-Oriented Synthesis of 1,3-trans-Disubstituted Tetrahydroisoquinolines: Seven-Step Asymmetric Synthesis of Michellamines B and C.

Angew Chem Int Ed Engl. 2022 Aug 1;61(31):e202205245. Epub 2022 Jun 17 PubMed: 35616270

PAPER Teng X, Chen S, Nie Y, Xiao P, Yu X, Shao Z, Zheng S

Ligand recognition and biased agonism of the D1 dopamine receptor.

Nat Commun. 2022 Jun 8;13(1):3186. PubMed: 35676276

From Treadmills to Transcriptomes: Consortium Charts Molecular Responses to Exercise

RESEARCH NEWS 2024-05-03 Research News We all know that physical activity is good for us, and may even help stave off dementia. But what are the underlying molecular mechanisms? Understanding how exercise affects the entire body at the transcriptomic, proteomic, epigenetic, and m

PAPER Vetr NG, Gay NR, MoTrPAC Study Group, Montgomery SB

The impact of exercise on gene regulation in association with complex trait genetics.

Nat Commun. 2024 May 1;15(1):3346. PubMed: 38693125

PAPER Many GM, Sanford JA, Sagendorf TJ, Hou Z, Nigro P, Whytock K, Amar D, Caputo T, Gay NR, Gaul DA, Hirshman M, Jimenez-Morales D, Lindholm ME, Muehlbauer MJ, Vamvini M, Bergman B, Fern Ndez FM, Goodyear LJ, Ortlund EA, Sparks LM, Xia A, Adkins JN, Bodine SC, Newgard CB, Schenk S, MoTrPAC Study Group

Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue.

bioRxiv. 2023 Feb 4; PubMed: 36778330

PAPER MoTrPAC Study Group, Lead Analysts, MoTrPAC Study Group

Temporal dynamics of the multi-omic response to endurance exercise training.

Nature. 2024 May;629(8010):174-183. PubMed: 38693412

PAPER MoTrPAC Study Group

Molecular Transducers of Physical Activity Consortium (MoTrPAC): Human Studies Design and Protocol.

J Appl Physiol (1985). 2024 Apr 18; PubMed: 38634503

PAPER Sanford JA, Nogiec CD, Lindholm ME, Adkins JN, Amar D, Dasari S, Drugan JK, Fernández FM, Radom-Aizik S, Schenk S, Snyder MP, Tracy RP, Vanderboom P, Trappe S, Walsh MJ, Molecular Transducers of Physical Activity Consortium

Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise.

Cell. 2020 Jun 25;181(7):1464-1474. PubMed: 32589957

Jourdan Parent

Brandeis University
Waltham, United States

T21RS International Conference (5th)- Promoting research excellence in Down syndrome

CONFERENCE 2024-06-05 00:00:00-2024-06-08 00:00:00 Rome, Italy 05 &#x2013 08 June 2024 View Conference Website 0

UCB0022

THERAPEUTICS UCB S.A. Small Molecule Other Neurotransmitters In April 2021, Phase 1 began with a safety and pharmacokinetic study of single and multiple ascending doses in healthy people and people with Parkinson’s. A total of 100 volunteers were exposed to drug, agai

Erik Johnson on In ADAD, Plaque Removal Improves Synaptic and Inflammatory Biomarkers

COMMENT This is a very nice study from the DIAN-TU team, reporting the effects of anti-amyloid therapy with gantenerumab and solanezumab on CSF and plasma biomarkers as measured by the Roche NeuroToolKit in dominantly inherited Alzheimer’s disease. Although the s

In ADAD, Plaque Removal Improves Synaptic and Inflammatory Biomarkers

RESEARCH NEWS 2024-05-03 Research News Scientists still have much to learn about how Aβ immunotherapy affects downstream processes in the brain. In the April 29 JAMA Neurology, researchers led by Eric McDade at Washington University School of Medicine, St. Louis, offer some hints