PAPER Skacik P, Kurca E, Sivak S
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PAPER Silvestri C, Almici V, Libri I, Mattioli I, Cosseddu M, Turrone R, Rivolta J, Grassini C, Caratozzolo S, Alberici A, Marengoni A, Pilotto A, Borroni B, Padovani A, Benussi A
Sex Differences in the Severity and Progression of Neuropsychiatric Symptoms Across Different Dementia Types.
Neurol Clin Pract. 2024 Jun;14(3):e200299. Epub 2024 Apr 18 PubMed: 38720954PAPER Yu L, Wang T, Hansson O, Janelidze S, Lamar M, Arfanakis K, Bennett DA, Schneider JA, Boyle PA
MRI-Derived AD Signature of Cortical Thinning and Plasma P-Tau217 for Predicting Alzheimer Dementia Among Community-Dwelling Older Adults.
Neurol Clin Pract. 2024 Jun;14(3):e200291. Epub 2024 Apr 15 PubMed: 38720951PAPER Krix S, Wilczynski E, Falgàs N, Sánchez-Valle R, Yoles E, Nevo U, Baruch K, Fröhlich H
Towards early diagnosis of Alzheimer's disease: advances in immune-related blood biomarkers and computational approaches.
Front Immunol. 2024;15:1343900. Epub 2024 Apr 23 PubMed: 38720902PAPER Zong J, Yang Y, Wang H, Zhang H, Yang X, Yang X
The two-directional prospective association between inflammatory bowel disease and neurodegenerative disorders: a systematic review and meta-analysis based on longitudinal studies.
Front Immunol. 2024;15:1325908. Epub 2024 Apr 24 PubMed: 38720896PAPER Kim GH, Kim J, Choi WS, Kim YK, Lee KH, Jang JW, Kim JG, Ryu HJ, Yang SJ, Jang H, Jung NY, Kim KW, Jeong Y, Moon SY, Academic Committee of the Korean Dementia Association
Executive Summary of 2023 International Conference of the Korean Dementia Association (IC-KDA 2023): A Report From the Academic Committee of the Korean Dementia Association.
Dement Neurocogn Disord. 2024 Apr;23(2):75-88. Epub 2024 Apr 24 PubMed: 38720824PAPER Dahabiyeh LA, Nimer RM, Wells JD, Abu-Rish EY, Fiehn O
Diagnosing Parkinson's disease and monitoring its progression: Biomarkers from combined GC-TOF MS and LC-MS/MS untargeted metabolomics.
Heliyon. 2024 May 15;10(9):e30452. Epub 2024 Apr 27 PubMed: 38720721PAPER Fernandes JM, Gondim FA
A homozygous p.Val120Leu (c.358G > C) SOD1 mutation led to slowly progressive amyotrophic lateral sclerosis in a Brazilian family.
Amyotroph Lateral Scler Frontotemporal Degener. 2024 May 8;:1-3. PubMed: 38720484Gael Nicolas on Do Two APOE4 Alleles Always Mean Alzheimer's?
COMMENT This is a very appealing study on neuropathological changes and in vivo biomarkers in APOE4 homozygotes. A better knowledge on the history of biomarkers in different genetic contexts is indeed required for the future of AD prevention, beyond autosomal dom
Beyond Microglia—Alzheimer’s Gene PLCγ2 Acts on Synapses, Too
RESEARCH NEWS 2024-05-09 Research News The Alzheimer’s risk gene phospholipase C-γ2 has been thought to act mainly in microglia. Now, in a May 1 preprint on bioRxiv, researchers led by Jean-Charles Lambert, Julie Dumont, and Julien Chapuis at Institut Pasteur de Lille, France, Mi
Arne Ittner on Beyond Microglia—Alzheimer’s Gene PLCγ2 Acts on Synapses, Too
COMMENT This study by Coulon et al. is a tour de force, identifying and characterising an exciting neuronal function for the AD gene PLCγ2, which encodes a phospholipase enzyme involved in signal transduction. The multilaboratory team established a loss-of-functi
PAPER Xu X, Wen X, Bhimani S, Moosa A, Parsons D, Ha H, Jin T
G protein-coupled receptor-mediated membrane targeting of PLCγ2 is essential for neutrophil chemotaxis.
J Leukoc Biol. 2023 Jul 27;114(2):126-141. PubMed: 37040618PAPER Xia Z, Storm DR
The role of calmodulin as a signal integrator for synaptic plasticity.
Nat Rev Neurosci. 2005 Apr;6(4):267-76. PubMed: 15803158PAPER Coulon A, Rabiller F, Takalo M, Roy A, Martiskainen H, Siedlecki-Wullich D, Mendes T, Lemeu C, Carvalho L-I, Ehrardt A, MelodeFerias AR, Hulsman M, Najdek C, Lannette-Weimann N, Freire-Regatillo A, Amouyel P, Charbonnier C, Dols-Icardo O, Jeskanen H, Kuulasmaa T, Kurki M, Hardy J, Wagner M, Heikkinen S, Holstege H, Makinen P, Nicolas G, Mead S, Wagner M, Ramirez A, Rauramaa T, Palotie A, Sims R, Soininen H, vanSwieten J, Williams J, Willman R-M, Bellenguez C, Grenier-Boley B, Gelle C, Lambert E, Ayral A-
Neuronal downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease hallmarks
bioRxiv2024.04.29.591575Csaba Adori on More Evidence that Locus Coeruleus Demise Precedes Cortical Tangles
COMMENT It is well known that certain subcortical modulatory nuclei, including the pigmented pontine nucleus locus coeruleus (LC), exhibit very early tau cytoskeletal pathology. According to earlier large-scale and detailed neuropathological studies by Heiko Braa
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