Alzpedia
TDP-43
Synonyms: TAR DNA-binding protein 43, TDP43, TARDBP, ALS10, transactive response DNA-binding protein of 43 kDa
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References
Alzpedia Citations
Further Reading
News
- The Four Stages of TDP-43 Proteinopathy
- Paper Alert: TDP-43 Mouse No Model to Test ALS Therapeutics
- Paper Alert: Zebrafish Say TDP-43 Causes ALS by Loss of Function
- Does ALS Gene Police RNA, Keep Strands From Entangling?
- Chicago—Devilish Duo: Two Mutations Add Up to Familial ALS
- Are TDP-43 Mice Living Up to Expectations?
- Research Brief: Does Loss of TDP-43 Cause ALS-Like Disease in Mice?
- Slicing and Dicing: TDP-43 Teams Up With Nucleases to Make MicroRNAs
- TDP-43 Turns Itself Off, Inclusions a False Lead
- Québec: Teasing Out the Function of TDP-43
- Honolulu: TDP-43 Gets a Place in the Sun
- TDP-43: Modified and On the Move
Papers
- Roberson ED. Mouse models of frontotemporal dementia. Ann Neurol. 2012 Dec;72(6):837-49. PubMed.
- Ling SC, Polymenidou M, Cleveland DW. Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis. Neuron. 2013 Aug 7;79(3):416-38. PubMed.
- Baloh RH. How do the RNA-binding proteins TDP-43 and FUS relate to amyotrophic lateral sclerosis and frontotemporal degeneration, and to each other?. Curr Opin Neurol. 2012 Dec;25(6):701-7. PubMed.
- Gendron TF, Rademakers R, Petrucelli L. TARDBP mutation analysis in TDP-43 proteinopathies and deciphering the toxicity of mutant TDP-43. J Alzheimers Dis. 2013;33 Suppl 1:S35-45. PubMed.
- Rademakers R, Neumann M, Mackenzie IR. Advances in understanding the molecular basis of frontotemporal dementia. Nat Rev Neurol. 2012 Jun 26;8(8):423-34. PubMed.
- Lee EB, Lee VM, Trojanowski JQ. Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration. Nat Rev Neurosci. 2012 Jan;13(1):38-50. PubMed.
- Goedert M, Ghetti B, Spillantini MG. Frontotemporal dementia: implications for understanding Alzheimer disease. Cold Spring Harb Perspect Med. 2012 Feb;2(2):a006254. PubMed.