Earliest ALS Defects Said to Start in Disparate Places
Both motor neurons in the brain and neuromuscular junctions in the periphery exhibit defects in young ALS mouse models.
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Both motor neurons in the brain and neuromuscular junctions in the periphery exhibit defects in young ALS mouse models.
Irritability and depression emerge sooner in AD than in the general population.
Neurons derived from stem cells of people with amyotrophic lateral sclerosis bungle the transmission of electrical signals.
The addition of a sugar to β-secretase ramps up Aβ production. Could reducing that sweet addition slow progression of Alzheimer's?
Mice with amyloid plaques develop runaway neuroinflammation, whereas mice with tau tangles predominantly lose synapses, a gene-expression study reports.
People with Alzheimer’s overexpress the A2A receptor, which suppresses memory in mice.
Hollywood turns its attention to a rare form of dementia, giving a personal look at the impact of the disease.
All three PET agents demonstrate roughly equivalent abilities to detect brain amyloid, a new analysis finds.
Upper motor neurons, implicated in many neurodegenerative diseases, are sensitive to both cell stress and hyperexcitability.
Spinal taps have a bad rap. Are headaches really all that common afterwards, and are there ways to prevent them?
The classic kinase cascade conspires to commit programmed axonal degeneration after injury.
For the first time, scientists report a crystal structure of TSPO, a potential target for PET imaging of neuroinflammation.
Scientists have produced an atomic-level picture of a receptor implicated in both the sporadic and familial forms of Alzheimer’s.
The field of tau PET is growing rapidly as the leading tracer T807/AV1451 is more widely used and new compounds from Japan and Switzerland enter the scene with clinical trials of their own.
Human Amyloid Imaging Meeting Was Abuzz With Talk of Tau Tau Tracer T807/AV1451 Tracks Neurodegenerative Progression Tau PET Fits With CSF, Grows Over Time, Picks up Frontotemporal Cases What If It’s Not Garden-Variety AD? Telling Variants Apart by Where