Better Diagnosis with Blood Test Detecting Only Tau Made in Brain
Brain-derived forms of tau distinguished people with Alzheimer's from those with other neurodegenerative diseases.
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New Data Bolsters MTBR-Tau243 as Fluid Marker for Tangles
Mirroring earlier results, a larger study finds that high levels of this tau fragment in CSF tracked with neurofibrillary tangles, but not amyloid plaques.
A Tau Blood Test Tracks With Alzheimer's Neuropathology
Antemortem plasma p-tau217 predicted the extent of amyloid plaques and neurofibrillary tangles seen postmortem.
Plasma P-tau217 Picks Up Plaques, Tangles, Future Decline
In some patients, the blood Aβ42/40 test fell too close to the cutoff for specialists to confidently diagnose AD. Comorbidities, drugs also complicate results. Two CSF tests are FDA-approved.
In AD, CSF Immune Cells Hint at Mounting Mayhem in the Brain
CSF monocytes increasingly crank out the chemokine CXCL16, while T cells up its receptor, CXCR6. The same cross-talk unfolded among microglia and T cells around plaques.
Soluble Oligomer Assay Rivals Other Biomarkers in Detecting Preclinical AD
The assay captures α-sheet structure. It detected AD with 99 percent accuracy, including among healthy people who later became cognitively impaired.
Living in Greener Pastures May Cut Risk for Alzheimer’s, Parkinson’s
The more foliage near a person’s residence, the less likely they are to have either disease.
Could Personalizing Multimodal Interventions Give Them Oomph?
In a small pilot study, tailoring lifestyle changes to the individual boosted cognition, with an effect size three times that seen in the Finger trial.
Gantenerumab Mystery: How Did It Lose Potency in Phase 3?
In the Graduate trials, the anti-amyloid antibody gantenerumab cleared only half as much plaque as it had done in earlier studies. Is formulation or dosing to blame?
As Parkinson’s Progresses, Do Synuclein Fibrils Shape-Shift?
Conformers amplified from CSF of late-stage PD adopt distinct folds and trouble neurons.
Donanemab Mops Up Plaque Faster Than Aduhelm
In a head-to-head comparison, donanemab banished four times as much plaque in the first six months as aducanumab did, partly due to its faster titration.
In Small Trial, Gene Therapy Spurs ApoE2 Production
ApoE2 was detected in cerebrospinal fluid of ApoE4 carriers with Alzheimer’s disease who received a virus expressing the protective allele.
Introducing Alzforum Database of 137 APOE Gene Variants
Adding to our collection of APP, Presenilin, Tau, and Trem2 mutations, the new dataset curates neurologic and non-neurologic information, ranging from clinical to molecular.
Cognitive Tests Taken at Home Are on Par with In-Clinic Assessments
Six commonly used tests accurately detected dementia, even preclinical cognitive slippage, when given over video chat or face-to-face.
Two New Stabs at Vaccinating People Against Pathologic Tau
A liposomal anti-tau vaccine elicited a response against disease-linked forms of tau, outdoing a conjugated vaccine. A separate tack to vaxx against tau is waiting in the wings.
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