New data suggest that the proteasome takes the first stab at dissolving these protein conglomerates, with autophagy coming in later to mop up.
Contradicting current opinion, a randomized trial made people stronger but, if anything, left their mental function weaker. What gives?
Antisense oligonucleotides are raising hopes for tackling a wide range of brain disorders—is the enthusiasm warranted?
As RNA Therapies Come of Age, Efficacy Remains Weak At AAN, Sights Set on Antisense Therapies for Diseases of the Brain New Alzheimer’s and Parkinson’s Immunotherapy Data at AAN Will RNA molecules that bump up or tamp down gene expression live up to their ...
At AAN, the latest data from Phase 3 trials and open-label extensions of RNA-targeting therapies reveal a bit of benefit, but no cure.
Genetic adaptations that gave humans their smarts may promote diseases of aging, including cancer, Alzheimer’s, and Parkinson’s. One adaptation counteracted REST, a proposed protector against AD.
High vascular risk scores and Aβ burden independently associate with cognitive decline, but combined, they speed things up.
Prior evidence for protective effect evaporates after adjustment for demographic differences in high- and low-lithium communities.
PET study finds tau signal associated with markers of cerebrovascular disease and cognitive issues.
Not the brown trucks with the friendly delivery guys: UPS as in unconventional protein secretion pathway. Tau rides it to slink out of one cell, and, grabbing onto heparin sulfate proteoglycans, enter another.
The company has halted all trials of atabecestat.
Engineered nanoparticles snatched extracellular Aβ, ferried it into cells, and switched on autophagy, clearing the peptide from the brains of mice. Would this work as a drug?
Contrary to previous findings, both proteins seem to escape via passive diffusion. This has implications for therapeutic strategies to keep them where they belong.
Aggregates that form inside, or just pass through, oligodendrocytes take on the properties of the virulent strain that gives rise to multiple system atrophy.
ApoE4 raises CSF tau more in women than in men, suggesting sex may influence the risk of neurodegeneration, especially in amyloid-positive E4 carriers.
No filters selected