No Easy Answers on Clinical Meaningfulness of Alzheimer’s Treatments
Meaningfulness must account for the disease stage a patient is at, his or her priorities, and effects over time, researchers say.
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New Stem Cell-Derived Neuron Datasets Available
Scientists turned iPSCs from people with ALS or Parkinson’s into motor neurons or dopaminergic neurons, respectively, then characterized them with a plethora of multi-omics.
Paper Alert: Plasma P-tau217 Predicts Future Cognitive Decline
Cognitively normal older adults with high levels of the biomarker slid quickly toward dementia.
Single-Nuclei Multi-omics Spots Wonky Gene Regulation
Can joint analysis of gene expression, chromatin, and transcription factors help explain how transcription changes in Alzheimer’s disease?
When Perivascular Macrophages Spew SPP1, Microglia Eat Synapses
In mice, oligomeric Aβ causes these macrophages to produce SPP1. Knocking out this pro-inflammatory cytokine quiets microglia and protects synapses.
Catch and Release: Cryo-EM Reveals How LRP2 Receptor Recycles Cargo
As it moves from the neutral pH of the cell surface to the acidic environs of the endosome, LRP2 switches its conformation from ligand receiver to dumper.
Higher-Resolution Spatial Transcriptomics Maps Mayhem Near Plaques
Microglia within 10 micrometers of Aβ plaques expressed a disease-associated signature. Astrocytes rubbernecked from a bit farther away.
Can ‘Cryptic Peptides’ Peg People with TDP-43 Pathology?
Mis-splicing events produce novel proteins that can be detected in the cerebrospinal fluid of ALS/FTD patients before their symptoms start.
The Chaperone FKBP12 Shields Tau from Aggregation
The protein binds to segments of tau that are prone to aggregate, preventing tangles and neurodegeneration.
Nothing to Sneeze At: Viruses Raise Risk of Neurodegenerative Disease
Twelve severe viral illnesses boosted risk up to 15 years after infection.
When SORL1 Dimerizes in Endosomes, Retromers Recycle APP Faster
SORL1 may form polymers that bind and stabilize the retromer, facilitating the recycling of APP and other substrates.
Not All Bad: Phosphorylated α-Synuclein Modulates Neurotransmission
p-S129syn better binds its synaptic vesicle protein partners than does plain α-synuclein.
In Nasu-Hakola Disease, DAP12-Deficient Microglia Kick Repair into Overdrive
The first study to survey the brain transcriptomes of people with NHD found microglia and astrocytes frantically repairing injury, and narrowing blood vessels.
Did Dementia Patient Care Go Downhill During the COVID Pandemic?
Data from six countries showed prescriptions for antipsychotic drugs rose in 2020, and remain high.
Droplets in the Bucket? Introducing en Masse Single-Synapse RNA-Seq
A new method reveals distinct synaptic states, some tied to amyloidosis, that were not seen in prior nuclear transcriptomic data.
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