21 Jun 2024
Injected into the cerebrospinal fluid, a viral vector delivers the lysosomal protein into the human brain. In mice, a protein transport vehicle delivered into the blood does the same.
21 Jun 2024
A panel of eight plasma proteins identified people who were on the path to Parkinson’s. Could this help select participants for prevention trials?
14 Jun 2024
With limited guidance, physicians will have to navigate questions about whom to treat, when to stop, and how to manage safety.
14 Jun 2024
People who sifted through piles of debris are nine times likelier to develop early onset, all-cause dementia than those exposed to little toxic dust.
13 Jun 2024
C05-05 binds α-synuclein deposits in the mouse, marmoset, and human brain. Uptake in the PD midbrain correlated with motor symptom severity.
10 Jun 2024
All 11 committee members voted that the antibody was effective for people with MCI or mild AD dementia, with its benefits outweighing risks.
08 Jun 2024
When carrying a pathogenic tau variant, microglia were bad at phagocytosis, barely made TREM2, and spat out neurotoxic proteins.
07 Jun 2024
As flies age, mitochondrial damage in their neurons somehow ages glia, which, in turn, cause lipid droplets to pile up on other, healthy glia.
07 Jun 2024
The enzyme cleaves off three amino acids at a time with a twist of the substrate, and a helping hand from a β-strand.
31 May 2024
The astrocytic receptor enforces distancing among glial cells. Free from this constraint, they better contain plaques.
31 May 2024
A new study challenges this idea, finding that in mice, clearance of an injected dye slowed during sleep and anesthesia.
30 May 2024
When the nuclear RNA-binding proteins NONO and SFPQ accumulate, adenosine-to-inosine editing of RNA runs amok. This spoils transcripts for axonal, synaptic, and mitochondrial proteins.
28 May 2024
FDA qualification would streamline the use of plasma NfL to select asymptomatic carriers of pathogenic frontotemporal dementia mutations for enrollment in prevention trials.
23 May 2024
Scientists correlated the PET signal in PSP patients with tau deposits in postmortem brain; the signal arises from neurons and oligodendrocytes.
23 May 2024
People born in the 1970s had 15 percent more surface area in their cortices than those born in the 1930s.