Introducing Alzforum Database of 137 APOE Gene Variants
Adding to our collection of APP, Presenilin, Tau, and Trem2 mutations, the new dataset curates neurologic and non-neurologic information, ranging from clinical to molecular.
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Adding to our collection of APP, Presenilin, Tau, and Trem2 mutations, the new dataset curates neurologic and non-neurologic information, ranging from clinical to molecular.
Six commonly used tests accurately detected dementia, even preclinical cognitive slippage, when given over video chat or face-to-face.
A liposomal anti-tau vaccine elicited a response against disease-linked forms of tau, outdoing a conjugated vaccine. A separate tack to vaxx against tau is waiting in the wings.
In Phase 3 trials, the drug reduced agitation more than placebo; however, both groups benefited substantially.
Scientists at CTAD found the Phase 3 trial well-done, the data consistent, and expect the drug to be approved. Priorities: grow the effect, understand the bleeding risk.
Dare We Say Consensus Achieved: Lecanemab Slows the Disease Brexpiprazole Eases Agitation in People with AD; So Does Being in a Trial Two New Stabs at Vaccinating People Against Pathologic Tau Cognitive Tests Taken at Home Are on Par with In-Clinic Assess
These axonal swellings block action potentials, weakening neural networks in mice. PLD3, an Alzheimer’s disease risk gene, may be involved.
In two primary tauopathies, fragments containing tau’s microtubule-binding region drop in the CSF as they accumulate in the brain.
Knocking down the synaptic scaffolding protein in mice eased neurofibrillary tangles, gliosis, and neurodegeneration.
Along with previously identified rare variants in TREM2, SORL1, and ABCA7, a massive exome sequencing effort identified variants in ATP8B4 and ABCA1.
Without this mechanosensor, microglia slowly respond to plaques. In mice, a Piezo1 agonist bolstered plaque containment and lowered amyloid burden.
In mice, this glycoprotein fragment accelerated amyloid deposition in cerebral blood vessels; in people, higher levels correlated with faster cognitive decline and greater AD risk.
Phospho-tau and tangles accumulated, microglia bloated with lipids, and the brain atrophied in these mice.
The antibody removed less plaque than expected and did not slow cognitive decline, according to top-line data. Detailed data to come at CTAD.
These unassuming cells keep cerebral vessels supple, forcing CSF through the brain and clearing Aβ. Their abilities wane with age, but can be restored.
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