Introducing Alzforum Database of 137 APOE Gene Variants
Adding to our collection of APP, Presenilin, Tau, and Trem2 mutations, the new dataset curates neurologic and non-neurologic information, ranging from clinical to molecular.
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Cognitive Tests Taken at Home Are on Par with In-Clinic Assessments
Six commonly used tests accurately detected dementia, even preclinical cognitive slippage, when given over video chat or face-to-face.
Two New Stabs at Vaccinating People Against Pathologic Tau
A liposomal anti-tau vaccine elicited a response against disease-linked forms of tau, outdoing a conjugated vaccine. A separate tack to vaxx against tau is waiting in the wings.
Brexpiprazole Eases Agitation in People with AD; So Does Being in a Trial
In Phase 3 trials, the drug reduced agitation more than placebo; however, both groups benefited substantially.
Dare We Say Consensus Achieved: Lecanemab Slows the Disease
Scientists at CTAD found the Phase 3 trial well-done, the data consistent, and expect the drug to be approved. Priorities: grow the effect, understand the bleeding risk.
Clinical Trials on Alzheimer's Disease (CTAD) 2022
Dare We Say Consensus Achieved: Lecanemab Slows the Disease Brexpiprazole Eases Agitation in People with AD; So Does Being in a Trial Two New Stabs at Vaccinating People Against Pathologic Tau Cognitive Tests Taken at Home Are on Par with In-Clinic Assess
Dystrophic Neurites Dampen Long-Range Neuronal Signaling
These axonal swellings block action potentials, weakening neural networks in mice. PLD3, an Alzheimer’s disease risk gene, may be involved.
Finally, a Biomarker to Distinguish Primary Tauopathies?
In two primary tauopathies, fragments containing tau’s microtubule-binding region drop in the CSF as they accumulate in the brain.
Bassoon Heralds Spread of Toxic Tau
Knocking down the synaptic scaffolding protein in mice eased neurofibrillary tangles, gliosis, and neurodegeneration.
Rare Variants in Lipid Transporter Genes Increase Risk for Alzheimer’s Disease
Along with previously identified rare variants in TREM2, SORL1, and ABCA7, a massive exome sequencing effort identified variants in ATP8B4 and ABCA1.
Piezo1 Steers Microglia Toward Rigid Aβ Plaques
Without this mechanosensor, microglia slowly respond to plaques. In mice, a Piezo1 agonist bolstered plaque containment and lowered amyloid burden.
Meddling Medin: A Vascular Amyloid That Promotes CAA?
In mice, this glycoprotein fragment accelerated amyloid deposition in cerebral blood vessels; in people, higher levels correlated with faster cognitive decline and greater AD risk.
Sans TREM2, ApoE4 Drives Microgliosis and Atrophy in Tauopathy Model
Phospho-tau and tangles accumulated, microglia bloated with lipids, and the brain atrophied in these mice.
Gantenerumab Falls Short in Phase 3
The antibody removed less plaque than expected and did not slow cognitive decline, according to top-line data. Detailed data to come at CTAD.
Perivascular Macrophages: New Target in Aging and Alzheimer’s Disease?
These unassuming cells keep cerebral vessels supple, forcing CSF through the brain and clearing Aβ. Their abilities wane with age, but can be restored.
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