Research Models

APOE2 Knock-In (JAX)

Synonyms: APOE2 KI, APOE*2 KI

Species: Mouse
Genes: APOE
Modification: APOE: Knock-In
Disease Relevance: Alzheimer's Disease
Strain Name: B6.Cg-Apoeem3(APOE*)Adiuj/J
Genetic Background: C57BL/6J
Availability: Available for Registering Interest, The Jackson Laboratory, Stock# 029017

Summary

APOE2 KI mice express humanized APOE (isoform 2) from the endogenous Apoe locus.

Modification Details

APOE2 KI mice were generated by using CRISPR/Cas9 to introduce two point mutations (leading to arginine to cysteine substitutions at amino acids 130 and 176) in an existing humanized APOE4 knock-in allele (Apoetm1.1(APOE*4)Adiuj, The Jackson Laboratory Stock# 027894).

Phenotype Characterization

When visualized, these models will distributed over a 18 month timeline demarcated at the following intervals: 1mo, 3mo, 6mo, 9mo, 12mo, 15mo, 18mo+.

Absent

No Data

  • Plaques
  • Tangles
  • Neuronal Loss
  • Gliosis
  • Synaptic Loss
  • Changes in LTP/LTD
  • Cognitive Impairment

Plaques

No data.

Tangles

No data.

Neuronal Loss

No data.

Gliosis

No data.

Synaptic Loss

No data.

Changes in LTP/LTD

No data.

Cognitive Impairment

No data.

Last Updated: 29 Nov 2018

COMMENTS / QUESTIONS

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References

External Citations

  1. The Jackson Laboratory Stock# 027894
  2. The Jackson Laboratory, Stock# 029017
  3. The Jackson Laboratory Stock# 027894

Further Reading

No Available Further Reading