This database is a repository of genetic variants in genes linked to Alzheimer’s disease (AD). Currently, it includes the three genes associated with autosomal-dominant AD (APP, PSEN1, PSEN2), plus two genes associated with AD by way of genetics or the neuropathology of the encoded protein (TREM2 and MAPT). The goal is to provide a comprehensive list of variants within these genes, ranging from causative to benign. For each variant, we capture the salient clinical and neuropathologic features, as well as functional effects, as reported in the literature.
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