Antibody

Tau (MC1)

Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: Formerly available through Dr. Peter Davies. For updated information, contact antibodies@alzforum.org.
Reactivity:
Reacts in: Human, Mouse

Immunogen/Epitope

conformation dependent antibody (epitope within aa 312-322)

Specificity

reactivity depends on both the N terminus (amino acids 7–9), and an amino acid sequence of tau (amino acids 313–322) in the third microtubule binding domain. Recognizes neurofibrillary tangles but does not react with FAC1

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References

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Further Reading

Papers

  1. . A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. J Clin Invest. 2009 May;119(5):1382-95. PubMed.
  2. . The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy. J Biol Chem. 2007 Oct 26;282(43):31755-65. Epub 2007 Aug 23 PubMed.
  3. . Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices. J Neurosci. 2006 May 31;26(22):6103-14. PubMed.
  4. . Tau filament formation in transgenic mice expressing P301L tau. J Biol Chem. 2001 Jan 5;276(1):529-34. PubMed.
  5. . Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science. 2001 Jul 27;293(5530):711-4. Epub 2001 Jun 14 PubMed.