Tau (MC1)


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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: Formerly available through Dr. Peter Davies. For updated information, see AlzAntibodies page linked in Note below.
Reacts in: Human, Mouse


conformation dependent antibody (epitope within aa 312-322)


reactivity depends on both the N terminus (amino acids 7–9), and an amino acid sequence of tau (amino acids 313–322) in the third microtubule binding domain. Recognizes neurofibrillary tangles but does not react with FAC1


Please see new entry for MC-1 in the AlzAntbodies database.

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AlzAntibodies Citations

  1. Tau (MC-1)

Further Reading


  1. . A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. J Clin Invest. 2009 May;119(5):1382-95. PubMed.
  2. . The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy. J Biol Chem. 2007 Oct 26;282(43):31755-65. Epub 2007 Aug 23 PubMed.
  3. . Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices. J Neurosci. 2006 May 31;26(22):6103-14. PubMed.
  4. . Tau filament formation in transgenic mice expressing P301L tau. J Biol Chem. 2001 Jan 5;276(1):529-34. PubMed.
  5. . Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science. 2001 Jul 27;293(5530):711-4. Epub 2001 Jun 14 PubMed.