Alzheimer's Disease vs Control: tau-p217 (Plasma and Serum)


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Recently developed assays target tau phosphorylated at threonine 217 (tau-p217). Both eligible studies found greater levels of plasma tau-p217 in people with Alzheimer’s disease than controls, albeit with quite different effect sizes, and the meta-analysis showed a non-significant trend towards elevation in AD (effect size = 3.876, p = 0.082). Tau-p217, in plasma or CSF, has been reported to discriminate Alzheimer’s disease from other dementias better than does tau-p181 (10 Apr 2020 news and 29 Jul 2020 news).

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How to interpret a forest plot: Each individual effect size (ES) is a ratio of the mean biomarker level in one condition over the mean level in another condition. An ES equal to 1 means that the two conditions had identical mean values. An ES > 1 indicates higher levels in the first condition, whereas an ES < 1 indicates lower levels in the first condition. The overall ES, indicated by a black diamond, is a weighted average of the individual effect sizes. The weight of each data point was determined by the inverse of the variance and is reflected in the size of each square. The width of the overall ES diamond is determined by the 95 percent confidence interval. Data out of range of the scale, including ES and confidence intervals, are indicated by an arrowhead at the edge of the plot, when applicable. 

Version 3.0, July 2021.