And Then There Were Five: CSF Proteomics Defines Alzheimer’s Subtypes
Each associates with distinct AD risk variants, brain atrophy, and disease severity.
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Each associates with distinct AD risk variants, brain atrophy, and disease severity.
Envelope proteins from endogenous retroviruses help shuttle tau seeds between cells. Could HERVs fuel tauopathies?
Alzheimer’s researchers got their first look at data from the positive Phase 3 trial. Many expect this antibody to become the third approved immunotherapy for AD.
In a mouse amyloidosis model, a protective variant tightened the reins on plaques and spared synapses; a risk variant did the opposite.
Based on exploratory endpoints and post hoc analyses, TauRx claims HMTM benefits a subgroup of participants with MCI. Trialists are unconvinced.
NPTX2 binds complement C1q, disrupting signals to microglia to destroy synapses.
cGAS and STING initiate a type I interferon response, which weakens neurons’ resilience to tau pathology.
Transplanting a human cerebral organoid containing microglia into a mouse brain allows the cells to thrive in something close to their natural environment.
The agency reiterated its earlier decision that traditionally approved amyloid antibodies will be covered if physicians enter data into a patient registry.
In amyloidosis mice, decline of the hypothalamic melanin-concentrating hormone system jacks up neuronal activity, and contributes to sleep problems.
Feeding taurine to mice and monkeys increased the lifespan of the former and reduced signs of aging in both.
Between basic researchers and clinicians, momentum is growing to test BACE inhibition again. This time, at low doses.
A crop of new PET tracers that bind α-synuclein aggregates shows promise in tissue samples and in animal models. Will they prove potent enough for brain imaging?
Swapping allele expression in astrocytes lowered amyloid load, lessened gliosis, and improved memory. This works even after amyloidosis is in full swing.
In mice, the long noncoding RNA MEG3 mediated the death of human neurons, which accumulated tau tangles.