Amyloid Plaques’ Hold on Aβ42 Dampens Peptide’s Daily Rhythm
Diurnal variations disappear as less Aβ42 reaches cerebrospinal fluid. Findings may improve timing of daily amyloid treatments.
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Diurnal variations disappear as less Aβ42 reaches cerebrospinal fluid. Findings may improve timing of daily amyloid treatments.
Alzforum reviews the major newsmakers of the past 12 months.
The finding could help researchers develop safer, more effective immunotherapies, and might apply to other types of protein aggregates as well, scientists said.
By fusing disordered protein regions to a plant photoreceptor, scientists study how RNA-binding proteins form liquid droplets within the cytoplasm, and what leads these structures to spawn potentially toxic aggregates.
Three cytokines released by activated immune cells in the brain turn astrocytes into neuron-killing machines.
Disabling human tau mRNA in mice prevents—even reverses—tau buildup, suggesting a potential treatment for a multitude of human tauopathies.
A new mouse study correlates neurofibrillary tangles with navigation difficulties and impaired firing of “grid cells” in the entorhinal cortex.
Two parallel studies found different answers as to whether calorie-restricted macaques live longer than ones that eat their fill. A joint analysis sets the record straight.
Convened by ARUK to learn from the antibody’s billion-dollar bust, industry and academic leaders declare insufficient CNS target engagement, say peripheral sink did not work, and brainstorm how to move forward.
Solanezumab: Did Aβ ‘Reflux’ From Blood Confound Target Engagement in CSF? After Solanezumab: Where Should Alzheimer’s Research Go? At an expert meeting convened by Alzheimer’s Research UK, scientists from Eli Lilly shared Aβ biomarker data from the Exped
The acute state of confusion not only accelerates memory loss on its own, but also worsens decline caused by other pathologies, including Alzheimer’s disease.
In induced cells from people with a C9ORF72 expansion, the number of mutant transcripts matched the number of RNA foci per cell.
Neurons of the humble roundworm pack damaged organelles and protein aggregates into giant vesicles and heave them out into extracellular space. Do our neurons do that, too?
Transgenic mouse models devoid of gut microbes make fewer Aβ plaques.
A well-controlled trials shows that a year of treatment offers no cognitive benefit for older men with low testosterone levels.