Neurons Cave When Astrocytes Heap on the Complements
When provoked by Aβ, astrocytes unleash a torrent of inflammatory signals. Under it, neuronal dendrites wither and lingering synapses turn hyperactive.
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When provoked by Aβ, astrocytes unleash a torrent of inflammatory signals. Under it, neuronal dendrites wither and lingering synapses turn hyperactive.
In mouse models of AD, one astrocyte purinergic receptor makes glia hyperactive, while another may suppress memory. Both are upregulated in the AD brain, researchers report.
Tiny spheres full of oxygen soothe neuroinflammation and fight neurodegeneration, researchers reported at SfN. The concept may seem strange, but AD trials are on the horizon.
Scientists claim that MRI detects an Aβ oligomer-specific probe delivered to the mouse brain through the nose.
Researchers mimic neuroprotective RNAs with stable DNAs that can do the same job.
Posing as the amino acid tyrosine, the anti-aging compound resveratrol turns on a new target, PARP1.
Alzforum looks back on last year's research newsmakers.
Measuring total prion protein in cerebrospinal fluid could help clinicians differentiate between prion disease and rapidly progressing forms of dementia.
Like a second skin, a new kind of neural implant is as compliant as the protective dura membrane that envelops the central nervous system.
Sil1’s presence keeps the endoplasmic reticulum from activating a chronic stress response.
A study reports a high incidence of criminal behavior in people with frontotemporal dementia. Especially for the undiagnosed, real trouble lies ahead.
Three new therapies enhance the therapeutic effects of levodopa.
Partnership will sequence the entire genomes of 3,000 patients.
Cross-sectional biomarker data from the Colombian kindred confirm models of biomarker progression, but suggest an earlier drop in brain metabolism.
Using baseline brain scans, the model projects where atrophy will occur and metabolism will wane.